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Abaloparatide

Product Name
Abaloparatide
CAS No.
247062-33-5
Chemical Name
Abaloparatide
Synonyms
Abaloparatide;Abaloparatide (BA058)
CBNumber
CB73166331
Molecular Formula
C174H300N56O49
Formula Weight
3960.5896
MOL File
247062-33-5.mol
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Abaloparatide Property

form 
Solid
color 
White to off-white
Sequence
H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-N-Me-Ala-Lys-Leu-His-Thr-Ala-NH2
InChIKey
BVISQZFBLRSESR-XSCWXTNMSA-N
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Hazard and Precautionary Statements (GHS)

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Abaloparatide Chemical Properties,Usage,Production

Description

Abaloparatide is a parathyroid hormone receptor 1 (PTHR1) analog and a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide is used to treat osteoporosis.

Uses

Abaloparatide, a synthetic peptide analog of parathyroid hormone-related protein (PTHrP), has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of osteoporosis in specific patient populations. The drug is indicated for postmenopausal women who are at a high risk of fracture, which can be defined by a history of osteoporotic fracture, multiple risk factors for fracture, or those who have failed or are intolerant to other available osteoporosis therapies. In addition to its use in postmenopausal women, abaloparatide has also been approved for increasing bone density in men with osteoporosis who are at high risk for fractures. This approval extends to adult patients who have not responded effectively to or cannot tolerate other osteoporosis treatments. The drug is designed to stimulate bone formation, thereby reducing the risk of fractures associated with osteoporosis.

Mechanism of action

Abaloparatide is a human parathyroid hormone-related peptide [PTHrP(1-34)] analog, which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in BMD and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral site.

Side effects

Abaloparatide is well tolerated and has mild adverse effects. Patients may experience nausea, dizziness, headache, palpitations, and hypercalciuria. Abaloparatide has been associated with supraventricular extrasystoles and orthostatic hypotension. The common (≥5%) treatment-emergent adverse drug reactions in men with osteoporosis are injection site reactions, nasopharyngitis, arthralgia, bronchitis, and hypertension.
The adverse effects reported from a randomized, double-blind, placebo-controlled trial among postmenopausal women with osteoporosis receiving 80 mcg of abaloparatide daily for 18 months include hypercalcemia (11%), dizziness (10%), nausea (8%), headache (8%), palpitations (5%), fatigue (3%), upper abdominal pain (3%), and vertigo (2%).

Abaloparatide Preparation Products And Raw materials

Raw materials

Preparation Products

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Abaloparatide Suppliers

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View Lastest Price from Abaloparatide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Abaloparatide 247062-33-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
500KG
Release date
2024-07-10
hebei hongtan Biotechnology Co., Ltd
Product
Abaloparatide 247062-33-5
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000kg
Release date
2024-03-21
Shandong Huizhihan Supply Chain Co., Ltd
Product
Abaloparatide 247062-33-5
Price
US $0.00-0.00/BOX
Min. Order
1BOX
Purity
99%
Supply Ability
20T
Release date
2024-11-05