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Ginsenoside Rg1

Product Name
Ginsenoside Rg1
CAS No.
22427-39-0
Chemical Name
Ginsenoside Rg1
Synonyms
Rg1;SANCHINOSIDE C1;PANAXOSIDE A;ginsenosidea2;ginsenosideg1;panaxosiderg1;Gensenoside Rg1;GINSENOSIDE RGL;GINSENOSIDE RG1;Panaxsaponin Rg1
CBNumber
CB7331840
Molecular Formula
C42H72O14
Formula Weight
801.01
MOL File
22427-39-0.mol
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Ginsenoside Rg1 Property

Melting point:
194～197℃
Boiling point:
898.5±65.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
pka
12.91±0.70(Predicted)
form 
Solid
color 
White to Off-White
biological source
Panax notoginseng (Burk.) F.H.Chen
Stability:
Hygroscopic
InChIKey
YURJSTAIMNSZAE-OLCOBRLXNA-N
LogP
1.670 (est)
CAS DataBase Reference
22427-39-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
2-45-36/37-16-7-24/25
WGK Germany 
3
RTECS 
LY9537200
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2200
Product name
Ginsenoside Rg1
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$240
Updated
2025/07/31
Sigma-Aldrich
Product number
1291672
Product name
Ginsenoside Rg1
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$335
Updated
2025/07/31
Sigma-Aldrich
Product number
00370580
Product name
Ginsenoside Rg1
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$783
Updated
2025/07/31
TCI Chemical
Product number
G0533
Product name
Ginsenoside Rg1
Packaging
25MG
Price
$103
Updated
2025/07/31
TCI Chemical
Product number
G0533
Product name
Ginsenoside Rg1
Packaging
100MG
Price
$258
Updated
2025/07/31
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Ginsenoside Rg1 Chemical Properties,Usage,Production

Description

Ginsenoside RG1(Rg1) is a natural product found in Panax notoginseng, Panax ginseng, and Panax vietnamensis. It is one of the primary bioactive ingredients in Panax notoginseng saponins. Numerous studies have indicated that Rg1 plays significant roles in health benefits such as anticancer, neuroprotective, anti-senescence, anti-inflammation, and antioxidative effects. Also, extensive research has demonstrated that Rg1 is associated with various diseases, including cardiovascular disease, Alzheimer’s disease, spinal cord injury, and liver injury. Xue et al. and Yu et al. demonstrated that Rg1 ameliorated streptozotocin-induced oxidative stress and myocardial apoptosis and suppressed HG-induced mesenchymal activation and fibrosis[1].

Chemical Properties

White solid

Uses

Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.

Definition

ChEBI: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 <ital pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 posit on.

in vivo

In the inflamed joints of adjuvant-induced arthritis (AIA) rats, the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Ginsenoside Rg1 in vivo inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression[2]. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer's disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with Ginsenoside Rg1 and Ginsenoside Rg2 (Ginsenoside Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with Ginsenoside Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. Ginsenoside Rg1 and Ginsenoside Rg2 reduce Aβ1-42 accumulation in APP/PS1 mice. In the Ginsenoside Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible[1].

IC 50

Aβ1-42; p65

References

[1] Hui Liu. “Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.” Annals of translational medicine 9 24 (2021): 1789.

Ginsenoside Rg1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ginsenoside Rg1 Suppliers

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View Lastest Price from Ginsenoside Rg1 manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
Ginsenoside Rg1 22427-39-0
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-10-13
Shaanxi Xianhe Biotech Co., Ltd
Product
GINSENOSIDE Rg1 22427-39-0
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-29
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Product
Ginsenoside Rg1 22427-39-0
Price
US $0.00/g
Min. Order
1g
Purity
50%-98% HPLC
Supply Ability
100kg
Release date
2024-03-14

22427-39-0, Ginsenoside Rg1Related Search:

Ginsenoside Rd GINSENOSIDE RE (20S)-Ginsenoside Rg2,GINSENOSIDE RG2 Ginseng extract Ginsenoside Rb1 Ginsenoside Rh2 GinsenosideRo TRIBULOSIDE Ginsenoside Re GINSENOSIDE F2 Panaxadiol Panaxatriol Ginsenoside-Rg5 Ginsenoside Rh1 GINSENOSIDEF1 Ginsenoside Rb3 Ginsenoside Rk3 GINSENOSIDE RB2

  • (3b,6a,12b)-3,12-dihydroxydammar-24-ene-6,20- diylbis(beta-d-glucopyranoside)
  • (3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diylbis[beta-D-glucopyranoside]
  • Ginsenoside Rg1 std.
  • Ginsenoside Rg1 (CAS# 22427-39-0)
  • Gensenoside Rg1
  • GINSENOSIDE RG1 WITH HPLC
  • GINSENOSIDE-RG1 (GINSENOSIDE A2: GINSENOSIDE G1)
  • dihydroxydammar-24-ene-6,20-diylbis-
  • β-D-Glucopyranoside, (3β,6α,12β)-3,12-
  • (3β,6α,12β)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-β-D-glucopyranoside
  • [3β,12β-Dihydroxy-5α-dammar-24-ene-6α,20-diyl]bis(β-D-glucopyranoside)
  • 20-(β-D-Glucopyranosyloxy)-3β,12β-dihydroxy-5α-dammara-24-ene-6α-yl β-D-glucopyranoside
  • 3β,12β-Dihydroxy-5α-dammar-24-ene-6α,20-diylbis(β-D-glucopyranoside)
  • Ginsenoside Rg1 ,98%
  • Ginsenoside Rg1(Sanchinoside C1)
  • Rg1
  • Ginsenoside Rg1 (saponin of Panax ginseng)
  • (6)-beta-d-glucopyranosyl-(20)-beta-d-glucopyranosyl-20s-protopanaxatriol
  • ginsenosidea2
  • ginsenosideg1
  • panaxosiderg1
  • DaMMarane, β-D-glucopyranoside deriv.
  • Panaxoside A(7CI)
  • Panaxsaponin Rg1
  • PANAXOSIDE A
  • SANCHINOSIDE C1
  • SANCHINOSIDE C1,PANAXOSIDE A
  • GINSENOSIDE RGL
  • GINSENOSIDE RG1
  • Ginsenoside Rg1, >=99%
  • Ginsenoside Rg1, 98%, from Panax ginseng C. A. Mey.
  • Ginsenoside Rg1 22427-39-0
  • Ginsenoside Rg1 RS
  • Ginsenoside Rg1 Standard
  • β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-
  • (2R,3R,4S,5S,6R)-2-(((3S,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-y
  • 20-(beta-D-Glucopyranosyloxy)-3beta,12beta-dihydroxydammar-24-en-6alpha-yl beta-D-Glucopyranoside
  • Ginsenoside Rg1 (10mM in DMSO)
  • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Ginsenoside Rg1 (8CI)
  • Ginsenoside Rg1 reference substance
  • Ginsenoside Rg1(P) (AHP Verified)
  • Ginsenoside Rg1, natural triterpenoid saponin
  • Multi-Component Ginsenoside Calibration Solution.
  • 22427-39-0
  • 11021-41-0
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Ginsenoside series
  • The group of Ginsenosides
  • Saponins