Methyltetrazine-PEG4-Azide

Product Name: Methyltetrazine-PEG4-Azide
CAS No.: 1802908-04-8
Chemical Name: Methyltetrazine-PEG4-Azide
Synonyms: Methyltetrazine-PEG4-Azide;Methyltetrazine-Ph-PEG4-azide
CBNumber: CB73345053
Molecular Formula: C17H23N7O4
Formula Weight: 389.42
MOL File: 1802908-04-8.mol

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Methyltetrazine-PEG4-Azide Property

solubility: Soluble in DMSO, DMF, DCM

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22446
Product name: Methyltetrazine-PEG4-azide
Purity: 95%
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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Methyltetrazine-PEG4-Azide Chemical Properties,Usage,Production

Description

Methyltetrazine-PEG4-azide is a herterobifunctional click chemistry reagent containing a methyltetrazine and azide moiety. The azide group can participate in copper-catalyzed Click Chemistry reactions with reagents such as alkynes, DBCO and BCN to form triazole moieties. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene)

Uses

Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-PEG4-Azide Preparation Products And Raw materials

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View Lastest Price from Methyltetrazine-PEG4-Azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Methyltetrazine-PEG4-azide 1802908-04-8
Price: US $0.00/mg
Min. Order: 10mg
Purity: >97.00%
Supply Ability: 100mg
Release date: 2024-03-20

1802908-04-8, Methyltetrazine-PEG4-AzideRelated Search:

Me-Tet-PEG4-NH2 TAMRA azide, 6-isomer PEP azide Cy5.5 Azide Biotin-PEG2-C6-Azide picolyl-azide-Acid Cy3 azide 6-Azido-hexanoic acid Cy5 Azide Desthiobiotin-PEG4-Alkyne Methyltetrazine-NHS Ester N-[2-[2-[2-[2-(Aminooxy)ethoxy]ethoxy]ethoxy]ethoxy]-4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetamide Dde Biotin-PEG4-Azide Dde Biotin-PEG4-Alkyne Methyltetrazine-PEG12-NHS ester Methyltetrazine-amido-PEG5-alkyne Methyltetrazine-PEG8-NHS ester Azidoacetic acid

Methyltetrazine-PEG4-Azide

Methyltetrazine-Ph-PEG4-azide

1802908-04-8