5-BROMO-2-(METHYLAMINO)PYRIMIDINE

Product Name: 5-BROMO-2-(METHYLAMINO)PYRIMIDINE
CAS No.: 31402-54-7
Chemical Name: 5-BROMO-2-(METHYLAMINO)PYRIMIDINE
Synonyms: 5-BROMO-2-(METHYLAMINO);5-Bromo-2-(methylamino)pyridine;5-BROMO-2-(METHYLAMINO)PYRIMIDINE;5-Bromo-N-methyl-2-pyrimidinamine;5-bromo-N-methylpyrimidin-2-amine;2-(Methylamino)-5-bromopyrimidine;(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE;2-Pyrimidinamine, 5-bromo-N-methyl-;Pyrimidine, 5-bromo-2-(methylamino)-;N-(5-Bromopyrimidin-2-yl)-N-methylamine
CBNumber: CB7342527
Molecular Formula: C5H6BrN3
Formula Weight: 188.03
MOL File: 31402-54-7.mol

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5-BROMO-2-(METHYLAMINO)PYRIMIDINE Property

Melting point:: 171-173℃
Boiling point:: 283.5±32.0 °C(Predicted)
Density: 1.686±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 2.07±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B696950
Product name: 5-Bromo-2-(methylamino)pyrimidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1746
Product name: 5-Bromo-2-(methylamino)pyrimidine
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1746
Product name: 5-Bromo-2-(methylamino)pyrimidine
Purity: 98%
Packaging: 5g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-9-W0
Product name: 5-Bromo-2-(methylamino)pyrimidine
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 118854
Product name: 5-Bromo-N-methylpyrimidin-2-amine
Purity: 95+%
Packaging: 1g
Price: $46
Updated: 2021/12/16

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5-BROMO-2-(METHYLAMINO)PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

32779-36-5

74-89-5

31402-54-7

1. 5-Bromo-2-chloropyrimidine (3 g, 15.5 mmol), 40% aqueous methylamine (35 ml) and methanol (20 ml) were added to a reaction flask and mixed well with stirring. 2. The reaction mixture was heated to reflux and kept at that temperature for 3 days. 3. After completion of the reaction, the reaction was cooled to room temperature. 4. The solvent was removed by evaporation using a rotary evaporator under reduced pressure. 5. The residue was extracted by partitioning with dichloromethane and 1M sodium hydroxide. 6. The residue was extracted by partitioning with dichloromethane and 1 M sodium hydroxide solution. 6. The organic layer was separated and dried over anhydrous magnesium sulfate. 7. After filtration to remove the desiccant, the solvent was again evaporated under reduced pressure using a rotary evaporator to give the white solid product 5-bromo-2-methylaminopyrimidine (3.0 g, 100% yield). 8. The product was characterized by 1H-NMR (CDCl3): δ 2.98 (3H, d, J=5.12 Hz), 5.16 (1H, brs), 8.29 (2H, s).

References

[1] Patent: US2010/130492, 2010, A1. Location in patent: Page/Page column 93
[2] Patent: WO2010/12747, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 90
[4] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 1, p. 34 - 38
[5] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 18

5-BROMO-2-(METHYLAMINO)PYRIMIDINE Preparation Products And Raw materials

Raw materials

acetonitrile Ethanol Sodium sulfate Methylamine 5-Bromo-2-chloropyrimidine 2-Aminopyrimidine Ethyl acetate Sodium bicarbonate Bromine Dichloromethane PETROLEUM ETHER Iodomethane

Preparation Products

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5-BROMO-2-(METHYLAMINO)PYRIMIDINE Suppliers

China 97 India 3 Poland 1 United Kingdom 3 United States 12 Global 116

Alchem Pharmtech,Inc.

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3B Scientific Corporation

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Synchem Inc.

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View Lastest Price from 5-BROMO-2-(METHYLAMINO)PYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 5-BROMO-2-(METHYLAMINO)PYRIMIDINE 31402-54-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-13

Career Henan Chemical Co

Product: 5-BROMO-2-(METHYLAMINO)PYRIMIDINE 31402-54-7
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

31402-54-7, 5-BROMO-2-(METHYLAMINO)PYRIMIDINERelated Search:

5-BROMO-2-MORPHOLIN-1-YL-PYRIMIDINE 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE 1-(5-BROMOPYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID 1-(5-Bromopyrimidin-2-yl)piperidine-3-carboxylic acid 1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE 5-Bromopyrimidine 2-(Methylamino)pyridine 2-[4-(5-BROMOPYRIMIDIN-2-YL)PIPERAZIN-1-YL]ETHANOL 5-Bromo-2-(piperidin-1-yl)pyrimidine 5-BROMO-N-BUTYL-2-PYRIMIDINAMINE BENZYL-(5-BROMO-PYRIMIDIN-2-YL)-AMINE METHYL {[2-(ACETYLAMINO)-5-BROMO-6-METHYLPYRIMIDIN-4-YL]THIO}ACETATE N-(5-BROMO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE N-(5-BROMO-2-PYRIMIDINYL)-4-METHOXYBENZENECARBOXAMIDE N-(5-BROMO-4,6-DIMETHYLPYRIMIDIN-2-YL)-2-THIENYLFORMAMIDE N-ALLYL-N-(5-BROMO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE

5-BROMO-2-(METHYLAMINO)PYRIMIDINE

(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE

5-Bromo-2-(methylamino)pyridine

(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE, 95+%

2-(Methylamino)-5-bromopyrimidine

5-bromo-N-methylpyrimidin-2-amine

N-(5-Bromopyrimidin-2-yl)-N-methylamine

REF DUPL: N-(5-Bromopyrimidin-2-yl)-N-methylamine

2-Pyrimidinamine, 5-bromo-N-methyl-

5-Bromo-N-methyl-2-pyrimidinamine

5-BROMO-2-(METHYLAMINO)

Pyrimidine, 5-bromo-2-(methylamino)-

5-BROMO-2-(METHYLAMINO)PYRIMIDINE ISO 9001：2015 REACH

31402-54-7

Organohalides

Pyrimidine