ChemicalBook > CAS DataBase List > DL-Serine

DL-Serine

Product Name
DL-Serine
CAS No.
302-84-1
Chemical Name
DL-Serine
Synonyms
SERINE;serin;DL-SER;DL-Serin;DL-Ser-OH;DL-SERINE;Serine, dl-;H-DL-SER-OH;DL-SERINE,FCC;DL-Serine >
CBNumber
CB7345179
Molecular Formula
C3H7NO3
Formula Weight
105.09
MOL File
302-84-1.mol
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DL-Serine Property

Melting point:
240 °C (dec.) (lit.)
Boiling point:
197.09°C (rough estimate)
Density 
1.53
refractive index 
1.4368 (estimate)
storage temp. 
Store below +30°C.
solubility 
H2O: soluble
form 
Crystalline Powder
pka
2.19(at 25℃)
color 
White
Odor
Odorless
Water Solubility 
50.23 g/L (25 ºC)
Merck 
14,8460
BRN 
1721402
LogP
-3.460
CAS DataBase Reference
302-84-1(CAS DataBase Reference)
NIST Chemistry Reference
DL-Serine(302-84-1)
EPA Substance Registry System
Serine (302-84-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
VT8100000
TSCA 
Yes
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4375
Product name
DL-Serine
Purity
≥98% (TLC)
Packaging
1kg
Price
$725
Updated
2025/07/31
Sigma-Aldrich
Product number
8.41235
Product name
DL-Serine
Purity
for synthesis
Packaging
100g
Price
$92.7
Updated
2025/07/31
Sigma-Aldrich
Product number
68353
Product name
DL-Serine
Purity
analytical standard
Packaging
100mg
Price
$51.8
Updated
2022/05/15
TCI Chemical
Product number
S0034
Product name
DL-Serine
Purity
>98.0%(T)
Packaging
25g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
S0034
Product name
DL-Serine
Purity
>98.0%(T)
Packaging
500g
Price
$143
Updated
2025/07/31
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DL-Serine Chemical Properties,Usage,Production

Description

DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.

Chemical Properties

DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.

Uses

DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.

Preparation

DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.?

Definition

ChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.

Application

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Serine helps retain the skin's moisture balance.

Synthesis Reference(s)

Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131
The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054

Biochem/physiol Actions

NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase

Safety Profile

When heated to decomposition emits toxic fumes of NOx.

in vitro

DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.

DL-Serine Preparation Products And Raw materials

Raw materials

Glycine

Preparation Products

D-Serine DL-GLYCERIC ACID MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Glycine L-Serine DL-Tryptophan L-Cystine Leuprorelin
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DL-Serine Suppliers

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View Lastest Price from DL-Serine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
DL-Serine 302-84-1
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-12
Anhuyan (Hainan) Biotechnology Co., LTD
Product
DL-Serine 302-84-1
Price
US $1.00/kg
Min. Order
0.001kg
Purity
99.99%
Supply Ability
20MT
Release date
2025-06-06
Wuhan JiyunZen Tech Co., Ltd.
Product
DL-Serine 302-84-1
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-08

302-84-1, DL-SerineRelated Search:

3-Hydroxypropionic acid D-Cycloserine 3-(4-Hydroxyphenyl)propionic acid L(+)-Lactic acid D-Serine DL-Malic acid 3-Aminopyridine Glycine L-Homoserine L-Serine β-Alanine DIETHYL FORMAMIDOMALONATE DIETHYL BENZAMIDOMALONATE Diethyl acetamidomalonate D(-)-allo-Threonine Dimethyl nitromalonate Diethyl nitromalonate N-Cbz-L-Serine

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