ChemicalBook > CAS DataBase List > 1-Boc-piperidine

1-Boc-piperidine

Product Name
1-Boc-piperidine
CAS No.
75844-69-8
Chemical Name
1-Boc-piperidine
Synonyms
1-BOC-PIPERIDINE;N-BOC-PIPERIDINE;1-Boc-Piperidine,98%;N-Boc-tetrahydropyridine;1-(tert-Butoxycarbonyl)piperidine;N-(TERT-BUTOXYCARBONYL)PIPERIDINE;tert-Butyl 1-piperidinecarboxylate;1-(tert-Butyloxycarbonyl)piperidine;tert-butyl piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)piperidine >
CBNumber
CB7348312
Molecular Formula
C10H19NO2
Formula Weight
185.26
MOL File
75844-69-8.mol
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1-Boc-piperidine Property

Boiling point:
130-140°C 15mm
Density 
0.964 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.454(lit.)
Flash point:
188 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
pka
-1.28±0.20(Predicted)
color 
Clear colorless to pale yellow
BRN 
3604898
CAS DataBase Reference
75844-69-8(CAS DataBase Reference)
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Safety

Hazard Codes 
T,N,Xi
Risk Statements 
25-36/37/38-50
Safety Statements 
26-36-45-60-61
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
HazardClass 
IRRITANT, KEEP COLD
PackingGroup 
Ⅲ
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4625
Product name
1-(tert-Butoxycarbonyl)piperidine
Purity
>98.0%(GC)
Packaging
5g
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
B4625
Product name
1-(tert-Butoxycarbonyl)piperidine
Purity
>98.0%(GC)
Packaging
25g
Price
$142
Updated
2025/07/31
TRC
Product number
B662033
Product name
1-BOC-Piperidine
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142536
Product name
tert-Butyl piperidine-1-carboxylate
Packaging
10g
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-FU
Product name
tert-Butyl piperidine-1-carboxylate
Packaging
5G
Price
$75
Updated
2021/12/16
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1-Boc-piperidine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Synthesis

110-89-4

24424-99-5

75844-69-8

The general procedure for the synthesis of tert-butyl piperidine-1-carboxylate from hexahydropyridine and di-tert-butyl dicarbonate is as follows: hexahydropyridine (1 mmol) was added to a solution of ethanol (1 mL) containing magnetically stirred guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) and the reaction was stirred to completion at 35-40 °C (reaction progress was monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, the product is almost pure after evaporation of the organic solvent. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using hexane and dichloromethane, or ether and petroleum ether as solvents) or silica gel column chromatography (ethyl acetate-hexane (1:6) as eluent).

References

[1] Synthesis, 2006, # 16, p. 2784 - 2788
[2] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043

1-Boc-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Boc-piperidine manufacturers

Career Henan Chemical Co
Product
1-Boc-piperidine 75844-69-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-02

75844-69-8, 1-Boc-piperidineRelated Search:

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  • tert-butyl piperidine-1-carboxylate
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  • 75844-69-8
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