1-Boc-piperidine
- Product Name
- 1-Boc-piperidine
- CAS No.
- 75844-69-8
- Chemical Name
- 1-Boc-piperidine
- Synonyms
- 1-BOC-PIPERIDINE;N-BOC-PIPERIDINE;1-Boc-Piperidine,98%;N-Boc-tetrahydropyridine;1-(tert-Butoxycarbonyl)piperidine;N-(TERT-BUTOXYCARBONYL)PIPERIDINE;tert-Butyl 1-piperidinecarboxylate;1-(tert-Butyloxycarbonyl)piperidine;tert-butyl piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)piperidine >
- CBNumber
- CB7348312
- Molecular Formula
- C10H19NO2
- Formula Weight
- 185.26
- MOL File
- 75844-69-8.mol
1-Boc-piperidine Property
- Boiling point:
- 130-140°C 15mm
- Density
- 0.964 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.454(lit.)
- Flash point:
- 188 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- pka
- -1.28±0.20(Predicted)
- color
- Clear colorless to pale yellow
- BRN
- 3604898
- CAS DataBase Reference
- 75844-69-8(CAS DataBase Reference)
Safety
- Hazard Codes
- T,N,Xi
- Risk Statements
- 25-36/37/38-50
- Safety Statements
- 26-36-45-60-61
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT, KEEP COLD
- PackingGroup
- Ⅲ
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- B4625
- Product name
- 1-(tert-Butoxycarbonyl)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- B4625
- Product name
- 1-(tert-Butoxycarbonyl)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- B662033
- Product name
- 1-BOC-Piperidine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB142536
- Product name
- tert-Butyl piperidine-1-carboxylate
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 4H56-1-FU
- Product name
- tert-Butyl piperidine-1-carboxylate
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
1-Boc-piperidine Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Synthesis
110-89-4
24424-99-5
75844-69-8
The general procedure for the synthesis of tert-butyl piperidine-1-carboxylate from hexahydropyridine and di-tert-butyl dicarbonate is as follows: hexahydropyridine (1 mmol) was added to a solution of ethanol (1 mL) containing magnetically stirred guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) and the reaction was stirred to completion at 35-40 °C (reaction progress was monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, the product is almost pure after evaporation of the organic solvent. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using hexane and dichloromethane, or ether and petroleum ether as solvents) or silica gel column chromatography (ethyl acetate-hexane (1:6) as eluent).
References
[1] Synthesis, 2006, # 16, p. 2784 - 2788
[2] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043
1-Boc-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-piperidine Suppliers
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View Lastest Price from 1-Boc-piperidine manufacturers
- Product
- 1-Boc-piperidine 75844-69-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02