Ethylmethyl-carbamic chloride

Uses Uses

Product Name: Ethylmethyl-carbamic chloride
CAS No.: 42252-34-6
Chemical Name: Ethylmethyl-carbamic chloride
Synonyms: ETHYLMETHYLCARBAMOYL CHLORIDE;n-ethyl-n-methylcarbamoyl chloride;Bosutinib Impurity 42;Rivastigmine Intermediate 1;Ethylmethy-Carbamic Chloride;Ethylmethyl-carbamic chloride;CARBAMIC CHLORIDE, ETHYLMETHYL-;N-ethyl-N-methyl caroylchloride;N-Ethyl-N-methylcarbamic chloride;N-ethyl-n-methylcarbamyl chloride
CBNumber: CB7352742
Molecular Formula: C4H8ClNO
Formula Weight: 121.57
MOL File: 42252-34-6.mol

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Ethylmethyl-carbamic chloride Property

Boiling point:: 89°C/40mmHg(lit.)
Density: 1.101±0.06 g/cm3(Predicted)
refractive index: 1.4500-1.4540
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka: -1.85±0.70(Predicted)
form: clear liquid
color: Colorless to Almost colorless
Stability:: Hygroscopic
InChI: InChI=1S/C4H8ClNO/c1-3-6(2)4(5)7/h3H2,1-2H3
InChIKey: XZVYDRLPXWFRIS-UHFFFAOYSA-N
SMILES: C(Cl)(=O)N(CC)C
CAS DataBase Reference: 42252-34-6(CAS DataBase Reference)

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Safety

RIDADR: 3265
HazardClass: 8
PackingGroup: II
HS Code: 2924190015

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: E0963
Product name: N-Ethyl-N-methylcarbamoyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $103
Updated: 2025/07/31

TRC

Product number: E925145
Product name: N-Ethyl-N-methylcarbamoyl Chloride
Packaging: 5g
Price: $185
Updated: 2021/12/16

TRC

Product number: E925145
Product name: N-Ethyl-N-methylcarbamoyl Chloride
Packaging: 50g
Price: $580
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4148-5-18
Product name: Ethylmethylcarbamic chloride
Packaging: 2g
Price: $25
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4148-5-18
Product name: Ethylmethylcarbamic chloride
Packaging: 5G
Price: $35
Updated: 2021/12/16

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Ethylmethyl-carbamic chloride Chemical Properties,Usage,Production

Uses

N-Ethyl-N-methylcarbamoyl chloride is used as an intermediate for rivastigmine.

Uses

N-Ethyl-N-methylcarbamoyl chloride is a compound that can be used in organic synthesis.

Chemical Properties

Pale Yellow Oil

Synthesis

624-78-2

32315-10-9

42252-34-6

Example 1: A solution of N-ethylmethylamine (100 g, 1.69 mol) in dichloromethane (1.5 L) was slowly added dropwise to a suspension in dichloromethane (2 L) containing sodium bicarbonate (284 g, 3.384 mol) and triphosgene (332 g, 1.117 mol), the temperature was maintained at a controlled level of 10-15°C, and the dropwise process lasted for 2 hours. After completion of the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting sodium chloride was removed by filtration and the filtrate was concentrated under reduced pressure to afford 189 g of N-methyl-N-ethylcarbamoyl chloride, the product being a light yellow oil (yield: 92%). Example 3: The procedure of Example 2 was repeated, only the solvent was changed to methylene chloride, and the rest of the reaction conditions remained unchanged. The experimental results are shown in Table 2, the yield consistently exceeded 98%.

References

[1] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 12; 13
[2] Research on Chemical Intermediates, 2014, vol. 40, # 2, p. 787 - 800
[3] Patent: WO2013/150529, 2013, A2. Location in patent: Page/Page column 24; 25; 28; 29
[4] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13

Ethylmethyl-carbamic chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethylmethyl-carbamic chloride Suppliers

Americas 1 Canada 2 China 223 Europe 2 India 45 Japan 1 Russia 1 South Korea 1 Switzerland 2 United Kingdom 8 United States 20 Global 306

Jinan Shengqi Pharmaceutical Co., Ltd

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J & K SCIENTIFIC LTD.

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Jia Xing Isenchem Co.,Ltd

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View Lastest Price from Ethylmethyl-carbamic chloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethylmethyl-carbamic chloride 42252-34-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethylmethyl-carbamic chloride 42252-34-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-20

Hangzhou ICH Biofarm Co., Ltd

Product: N,N-ETHYLMETHYL CARBAMOYL CHLORIDE 42252-34-6
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

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42252-34-6

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