Flavopiridol

Product Name: Flavopiridol
CAS No.: 146426-40-6
Chemical Name: Flavopiridol
Synonyms: Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
CBNumber: CB7362013
Molecular Formula: C21H20ClNO5
Formula Weight: 401.84
MOL File: 146426-40-6.mol

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Flavopiridol Property

Melting point:: 52.5 °C
Boiling point:: 603.6±55.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form: Yellow powder.
pka: 6.16±0.40(Predicted)
color: Light yellow to yellow
InChIKey: BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES: C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference: 146426-40-6(CAS DataBase Reference)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 25mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 50mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 100mg
Price: $656
Updated: 2024/03/01

ChemScene

Product number: CS-0018
Product name: Flavopiridol
Purity: 99.72%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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Flavopiridol Chemical Properties,Usage,Production

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

Flavopiridol Preparation Products And Raw materials

Raw materials

Preparation Products

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Flavopiridol Suppliers

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View Lastest Price from Flavopiridol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flavopiridol 146426-40-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Flavopiridol 146426-40-6
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-09

146426-40-6, FlavopiridolRelated Search:

CHLOROPHOSPHONAZO III Methyl salicylate METSULFURON METHYL Kresoxim-methyl Solvent Red 43 Thiophanate-methyl Tetrahydro-4H-pyran-4-one Tribenuron methyl Centchroman Haloperidol Methyl Flavopiridol (Alvocidib) HCl (R)-3-Hydroxypiperidine hydrocloride Methyl bromide 4H-PYRAN-4-ONE 4-PIPERIDIN-4-YLPHENOL 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE 4-(3-METHYLPHENYL)PIPERIDINE

FLAVOPIRIDOL

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-

Alvocidib

(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one

C077990

Hmr 1275

L 868275

L-868275

L86-8275

Flavopirodol

Flavopiridol(Alvocidib)

vopiridol(Alvocidib)

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one

FLAVOPIRIDOL; HMR-1275;L868275

Alvocidib, Free Base

Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one

Alvocidib(Flavopiridd)

Flavopiridol, >=99%

CS-180

Flavopiridol (HMR-1275, Alvocidib, L868275)

HMR-1275; L86-8275

FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)

L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275

Donepezil Impurity 63

146426-40-6

C21H20ClNO5

API intermediates

APIS