ChemicalBook > CAS DataBase List > Flavopiridol

Flavopiridol

Product Name
Flavopiridol
CAS No.
146426-40-6
Chemical Name
Flavopiridol
Synonyms
Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
CBNumber
CB7362013
Molecular Formula
C21H20ClNO5
Formula Weight
401.84
MOL File
146426-40-6.mol
More
Less

Flavopiridol Property

Melting point:
52.5 °C
Boiling point:
603.6±55.0 °C(Predicted)
Density 
1.448±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form 
Yellow powder.
pka
6.16±0.40(Predicted)
color 
Light yellow to yellow
InChIKey
BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES
C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference
146426-40-6(CAS DataBase Reference)
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
25mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
50mg
Price
$384
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
100mg
Price
$656
Updated
2024/03/01
ChemScene
Product number
CS-0018
Product name
Flavopiridol
Purity
99.72%
Packaging
5mg
Price
$60
Updated
2021/12/16
More
Less

Flavopiridol Chemical Properties,Usage,Production

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

IC 50

CDK1/Cyc B1: 30 nM (IC50); CDK2/Cyc E: 170 nM (IC50); CDK4/Cyc D1: 100 nM (IC50); MAP: 19000 nM (IC50); PKC: 14000 nM (IC50); EGFR: 22000 nM (IC50)

Flavopiridol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Flavopiridol Suppliers

China 206 Europe 1 Germany 2 United Kingdom 5 United States 31 Global 245
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
LC Laboratories
Tel
--
Fax
--
Email
custserv@lclabs.com
Country
United States
ProdList
503
Advantage
50
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Tinib-Tools
Tel
--
Fax
--
Country
United States
ProdList
164
Advantage
0
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
QVENTAS INC.
Tel
--
Fax
--
Email
mike@qventas.com
Country
United States
ProdList
383
Advantage
47
More
Less

View Lastest Price from Flavopiridol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Flavopiridol 146426-40-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Flavopiridol 146426-40-6
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-09

146426-40-6, FlavopiridolRelated Search:

CHLOROPHOSPHONAZO III Methyl salicylate METSULFURON METHYL Kresoxim-methyl Solvent Red 43 Tribenuron methyl Tetrahydro-4H-pyran-4-one Centchroman Haloperidol Thiophanate-methyl Methyl Flavopiridol (Alvocidib) HCl (R)-3-Hydroxypiperidine hydrocloride Methyl bromide 4H-PYRAN-4-ONE 4-PIPERIDIN-4-YLPHENOL 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE 4-(3-METHYLPHENYL)PIPERIDINE

  • FLAVOPIRIDOL
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
  • Alvocidib
  • (-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • C077990
  • Hmr 1275
  • L 868275
  • L-868275
  • L86-8275
  • Flavopirodol
  • Flavopiridol(Alvocidib)
  • vopiridol(Alvocidib)
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one
  • FLAVOPIRIDOL; HMR-1275;L868275
  • Alvocidib, Free Base
  • Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • Alvocidib(Flavopiridd)
  • Flavopiridol, >=99%
  • CS-180
  • Flavopiridol (HMR-1275, Alvocidib, L868275)
  • HMR-1275; L86-8275
  • FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)
  • L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275
  • Donepezil Impurity 63
  • Flavopiridol, 10 mM in DMSO
  • 146426-40-6
  • C21H20ClNO5
  • API intermediates
  • APIS