ChemicalBook > CAS DataBase List > 4-(pyridine-2-yl) pyrimidin-2-amine

4-(pyridine-2-yl) pyrimidin-2-amine

Product Name
4-(pyridine-2-yl) pyrimidin-2-amine
CAS No.
66521-65-1
Chemical Name
4-(pyridine-2-yl) pyrimidin-2-amine
Synonyms
BUTTPARK 41\09-82;Nilotinib Impurity 9(N-Oxide);Nilotinib 2-Pyridinyl Impurity;2-Amino-4-(2-pyridyl)pyrimidine;4-(2-PYRIDINYL)-2-PYRIMIDINAMINE;4-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE;2-Pyrimidinamine, 4-(2-pyridinyl)-;4-(2-pyridinyl)-2-pyrimidinylamine;2-amino-4-(2-pyridinyl)-pyrimidine;4-(pyridine-2-yl) pyrimidin-2-amine
CBNumber
CB7364224
Molecular Formula
C9H8N4
Formula Weight
172.19
MOL File
66521-65-1.mol
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4-(pyridine-2-yl) pyrimidin-2-amine Property

Melting point:
137-139°C
Boiling point:
426.5±37.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.34±0.10(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P991695
Product name
4-(2-Pyridinyl)-2-pyrimidinamine
Packaging
50mg
Price
$80
Updated
2021/12/16
TRC
Product number
P991695
Product name
4-(2-Pyridinyl)-2-pyrimidinamine
Packaging
100mg
Price
$120
Updated
2021/12/16
TRC
Product number
P991695
Product name
4-(2-Pyridinyl)-2-pyrimidinamine
Packaging
250mg
Price
$275
Updated
2021/12/16
Apolloscientific
Product number
OR110729
Product name
4-Pyridin-2-ylpyrimidin-2-amine
Packaging
1g
Price
$114
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-KB
Product name
4-Pyridin-2-ylpyrimidin-2-amine
Packaging
1g
Price
$125
Updated
2021/12/16
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4-(pyridine-2-yl) pyrimidin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Nilotinib.

Preparation

Synthesis of 4-(pyridine-2-yl) pyrimidin-2-amine (P2P). (0.5 g, 2.84 mmol) of (Z)-3- dimethylamino-1-(pyridine-2-yl)prop-2-en-1-one was suspended was suspended in 15ml of nbutanol. To the solution (0.346 g, 2.84 mmol) of guanidine nitrate added and followed by the addition of NaOH(0.114 g, 2.84 mmol) and reflux this mixture at 110℃ for 12h. After completion of the reaction the mixture was filtered, the clear yellow solution of filtrate kept for room temperature. After 20 min yellow crystal formed and dried in a vacuum under reduced pressure. Yield (0.296 g, 60%) IR (KBr): 3471, 3142, 1622, 1568, 1463, 1340, 1215, 1095, 993, 783, 650, 524.1H NMR (300 MHz, CDCl3) δ 8.69 (dd, J = 11.9, 10.0 Hz, 1H), 8.45 (dd, J = 5.1, 2.6 Hz, 1H), 8.40 – 8.20 (m, 1H), 7.85 (ddd, J = 17.9, 9.4, 7.3 Hz, 1H), 7.64 (dd, J = 5.1, 2.8 Hz, 1H), 7.53 – 7.30 (m, 1H), 5.30 (s, 2H). 13C NMR (75 MHz, CDCl3) δ 164.49 (s), 163.75 (s), 159.65 (s), 154.75 (s), 149.79 (s), 137.29 (s), 125.41 (s), 121.87 (s), 108.26 (s).

4-(pyridine-2-yl) pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(pyridine-2-yl) pyrimidin-2-amine Suppliers

Canada 1 China 35 France 1 Germany 1 India 3 United Kingdom 3 United States 11 Global 55
Standardpharm Co. Ltd.
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United States
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SynChem，Inc
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SynQuest Laboratories, Inc.
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Matrix Scientific
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CGeneTech, Inc.
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View Lastest Price from 4-(pyridine-2-yl) pyrimidin-2-amine manufacturers

Dideu Industries Group Limited
Product
4-(2-PYRIDINYL)-2-PYRIMIDINAMINE 66521-65-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-10

66521-65-1, 4-(pyridine-2-yl) pyrimidin-2-amineRelated Search:

2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol EMpagliflozin iMpurity 10 Butanoic acid, 4-chloro-3-hydroxy-, (3S)- Methanone, (5-chloro-2-iodophenyl)(2-fluorophenyl)- (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene Empagliflozin Impurity 32 (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone EMpagliflozin iMpurity 13 Empagliflozin Impurity 2-Chloro-5-iodobenzoic acid (R)-(-)-3-Hydroxytetrahydrofuran Engleet net impurity 07

  • 4-(2-PYRIDINYL)-2-PYRIMIDINAMINE
  • 4-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE
  • BUTTPARK 41\09-82
  • Nilotinib 2-Pyridinyl Impurity
  • Nilotinib Impurity 9(N-Oxide)
  • 4-(2-pyridinyl)-2-pyrimidinylamine
  • 4-(2-pyridinyl)-2-pyrimidinamine (en)
  • 2-amino-4-(2-pyridinyl)-pyrimidine
  • 2-Amino-4-(2-pyridyl)pyrimidine
  • 2-Pyrimidinamine, 4-(2-pyridinyl)-
  • 4-(2-PYRIDINYL)-2-PYRIMIDINAMINE ISO 9001：2015 REACH
  • 4-(pyridine-2-yl) pyrimidin-2-amine
  • 66521-65-1
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals