3-(BROMOMETHYL)PHENOL
- Product Name
- 3-(BROMOMETHYL)PHENOL
- CAS No.
- 74597-04-9
- Chemical Name
- 3-(BROMOMETHYL)PHENOL
- Synonyms
- AKOS 90890;3-(BROMOMETHYL)PHENOL;m-(Bromomethyl)phenol;3-Hydroxybenzylbromide;Phenol, 3-(bromomethyl)-;3-(Bromomethyl)phenol CAS NO.74597-04-9;6-Quinolinesulfonylchloride,1,2-dihydro-4-oxo-
- CBNumber
- CB7365827
- Molecular Formula
- C7H7BrO
- Formula Weight
- 187.03
- MOL File
- 74597-04-9.mol
3-(BROMOMETHYL)PHENOL Property
- Boiling point:
- 272℃
- Density
- 1.593
- Flash point:
- 118℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 9.55±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- RIDADR
- 2810
- HazardClass
- 6.1
- PackingGroup
- Ⅱ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B808033
- Product name
- 3-(Bromomethyl)phenol
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- Y9989
- Product name
- 3-(Bromomethyl)phenol
- Packaging
- 1g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 188374
- Product name
- 3-(Bromomethyl)phenol
- Packaging
- 1g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- HCH0142867
- Product name
- 3-(BROMOMETHYL)PHENOL
- Purity
- 98.00%
- Packaging
- 1G
- Price
- $1339.8
- Updated
- 2021/12/16
- Product number
- HCH0142867
- Product name
- 3-(BROMOMETHYL)PHENOL
- Purity
- 98.00%
- Packaging
- 5G
- Price
- $1501.5
- Updated
- 2021/12/16
3-(BROMOMETHYL)PHENOL Chemical Properties,Usage,Production
Uses
3-?(Bromomethyl)?phenol is a reagent used in synthesis of furan-based heterocycles. Also used in the preparation of tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptors.
Synthesis
620-24-6
74597-04-9
General procedure for the synthesis of m-hydroxybenzyl bromide from 3-hydroxybenzyl alcohol: Synthesis of Intermediate 17: 3-(bromomethyl)phenol A 50 mL round bottom flask was charged with 15 mL of dichloromethane and fitted with a magnetic stirrer. To the stirred solvent was added 3-hydroxymethylphenol (0.5 g, 4.03 mmol). After cooling the reaction mixture to 0°C, phosphorus tribromide (1.6 g, 0.56 mL, 6.04 mmol) was added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction mixture was diluted with 25 mL of dichloromethane and the organic layer was washed with 20 mL of water. The organic layer was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent to give a brown solid product (0.65 g, yield: 86.3%). Mass spectrum (ESI, 120 eV): m/z = 187.0 (M + H)+. 1H NMR (300MHz, CDCl3): δ 7.10-7.15 (t, 1H), 6.86-6.89 (d, 1H), 6.80 (d, 1H), 6.67-6.71 (m, 1H), 4.35-4.36 (d, 2H), 3.80-3.94 (broad peak, 1H).
References
[1] Chemische Berichte, 1989, vol. 122, p. 347 - 356
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 70; 71-72
[3] Patent: WO2014/31936, 2014, A2. Location in patent: Paragraph 0327; 0328
[4] Patent: WO2014/31928, 2014, A2. Location in patent: Paragraph 0334
[5] Patent: WO2005/68421, 2005, A1. Location in patent: Page/Page column 39-40
3-(BROMOMETHYL)PHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
3-(BROMOMETHYL)PHENOL Suppliers
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50793966 18917198199
- Fax
- +86-21-50793967
- info@synfarm.com
- Country
- China
- ProdList
- 280
- Advantage
- 58
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 0571-82896630 18969958410
- sales_hz@milestonepharmtech.com
- Country
- China
- ProdList
- 4894
- Advantage
- 55
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 18-086626237 18086626237
- Fax
- qq:2693528373
- 2693528373@qq.com
- Country
- China
- ProdList
- 2973
- Advantage
- 56
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1853
- Advantage
- 55
- Tel
- 021-20960837,QQ1332204249
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 3341
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-68882955 17721395025
- Fax
- 021-68882955
- 2423903095@qq.com
- Country
- China
- ProdList
- 4991
- Advantage
- 58
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 18610542700
- Fax
- 010-69737341
- 3138545@qq.com
- Country
- China
- ProdList
- 298
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-6387771-6039 18920764717
- sales@heowns.com
- Country
- China
- ProdList
- 23771
- Advantage
- 60
- Tel
- 0531-18763987518 18763987518
- levi@lihengpharm.com
- Country
- China
- ProdList
- 1797
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 18916696128
- service@snowpharm.com
- Country
- China
- ProdList
- 1369
- Advantage
- 58
- Tel
- 13120563767
- Fax
- 15669989863
- chemchen925@outlook.com
- Country
- China
- ProdList
- 987
- Advantage
- 58
- Tel
- 0371-55055611 18137792234
- Fax
- QQ：3002694073
- 3002694073@qq.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- +8613062833949
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 8645
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 025-52388076
- sales@jolinpharm.com
- Country
- China
- ProdList
- 141
- Advantage
- 58
- Tel
- 027-88320699
- Fax
- 027-88320962
- tycshyy@126.com
- Country
- China
- ProdList
- 1000
- Advantage
- 58
- Tel
- 1701086315
- Fax
- 1701086315@qq.com
- dexuanpharma@126.com
- Country
- China
- ProdList
- 9475
- Advantage
- 58
- Tel
- 0574-87314919 057487319282
- info@nbinno.com
- Country
- China
- ProdList
- 7047
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 15870833005
- 2232044025@qq.com
- Country
- China
- ProdList
- 8206
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- 19122915778
- 1549869036@qq.com
- Country
- China
- ProdList
- 498
- Advantage
- 58
- Tel
- 15553348166
- m15553348166@163.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 19131160546
- 2681315246@qq.com
- Country
- China
- ProdList
- 13199
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 13417589054;
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9069
- Advantage
- 58
- Tel
- 16696119288
- 779113375@qq.com
- Country
- China
- ProdList
- 7236
- Advantage
- 58
- Tel
- 029-029-81123119 17391733320
- 1021@dideu.com
- Country
- China
- ProdList
- 9995
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 19353112242
- 1816280386@qq.com
- Country
- China
- ProdList
- 8045
- Advantage
- 58
- Tel
- 021-68080707 18079794756
- soloman.lee@chemlin.com.cn
- Country
- China
- ProdList
- 8473
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11015
- Advantage
- 58
- Tel
- 18560864701
- 643971@qq.com
- Country
- China
- ProdList
- 6098
- Advantage
- 58
- Tel
- 16621224781
- syy@titansci.com
- Country
- China
- ProdList
- 2896
- Advantage
- 58
- Tel
- 0519-83556355 18015005120
- Fax
- -
- shikewei397@163.com
- Country
- China
- ProdList
- 3734
- Advantage
- 55
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 9995
- Advantage
- 58