ChemicalBook > CAS DataBase List > Methyl 3-amino-5-chloro-2-hydroxybenzoate

Methyl 3-amino-5-chloro-2-hydroxybenzoate

Product Name: Methyl 3-amino-5-chloro-2-hydroxybenzoate
CAS No.: 5043-81-2
Chemical Name: Methyl 3-amino-5-chloro-2-hydroxybenzoate
Synonyms: Azasetron Impurity 10;Methyl 3-amino-5-chlorosalicylate;3-amino-5-chloro-2-hydroxybenzoate;methyl 3-amino-5-chloro-2-hydroxybenzoate;3-Amino-5-chloro-salicylic Acid Methyl Ester;3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID ME ESTER;3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID METHYL ESTER;SALICYLICACID,3-AMINO-5-CHLORO-,METHYLESTER(7CI,8CI);Benzoic acid, 3-amino-5-chloro-2-hydroxy-, methyl ester;methyl 3-amino-5-chloro-2-hydroxybenzoate hydrochloride
CBNumber: CB7367265
Molecular Formula: C8H8ClNO3
Formula Weight: 201.61
MOL File: 5043-81-2.mol

Less

Methyl 3-amino-5-chloro-2-hydroxybenzoate Property

Melting point:: 71-73°C
Boiling point:: 322.0±42.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.11±0.23(Predicted)
form: Solid
color: Pale Brown to Brown
CAS DataBase Reference: 5043-81-2(CAS DataBase Reference)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: A603330
Product name: 3-Amino-5-chloroSalicylicAcidMethylEster
Packaging: 2g
Price: $240
Updated: 2021/12/16

TRC

Product number: A603330
Product name: 3-Amino-5-chloroSalicylicAcidMethylEster
Packaging: 10g
Price: $1070
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17619
Product name: 3-Amino-5-chloro salicylic acid methyl ester
Packaging: 10g
Price: $1201.2
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 19573
Product name: 3-Amino-5-chloroSalicylicAcidMethylEster
Packaging: 10g
Price: $1880
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012208
Product name: 3-AMINO-5-CHLORO-2-HYDROXY BENZOIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $2055.9
Updated: 2021/12/16

Less

Methyl 3-amino-5-chloro-2-hydroxybenzoate Chemical Properties,Usage,Production

Chemical Properties

Light Brown Solid

Uses

Intermediate in the preparation of Azasetron.

Synthesis

5043-79-8

5043-81-2

General procedure for the synthesis of methyl 3-amino-5-chloro-2-hydroxy-2-hydroxybenzoate from methyl 5-chloro-2-hydroxy-3-nitrobenzoate: Methyl 5-chloro-2-hydroxy-3-nitrobenzoate (2.00 g, 10.7 mmol) was dissolved in 6 mL of concentrated sulfuric acid and stirred at 0 °C. Subsequently, a mixture of concentrated sulfuric acid and concentrated nitric acid (1:1, 1.6 mL, v/v) was slowly added, and the reaction mixture was gradually warmed up to room temperature with continuous stirring for 24 hours. After the reaction was completed, the mixture was poured into ice water, the precipitate was collected by filtration, washed with water and dried to obtain the nitro compound. The nitro compound was suspended in a solvent mixture of 15 mL of ethyl acetate and 15 mL of methanol, 5% palladium/carbon catalyst (0.350 g) was added, and the hydrogenation reduction reaction was carried out at room temperature for 4 hours. At the end of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford methyl 3-amino-5-chloro-2-hydroxybenzoate solid 1.61 g in 74.6% yield. The product was characterized by 1H-NMR (CDCl3): δ 10.84 (1H, s), 7.20 (1H, d, J=2.4Hz), 6.83 (1H, d, J=2.4Hz), 3.94 (3H, s).

References

[1] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 3, p. 624 - 630
[2] Patent: JP2016/56134, 2016, A. Location in patent: Paragraph 0245; 0246; 0247
[3] Patent: US2014/275172, 2014, A1. Location in patent: Paragraph 0945

Methyl 3-amino-5-chloro-2-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methyl 3-amino-5-chloro-2-hydroxybenzoate Suppliers

Canada 1 China 100 Germany 1 India 2 United Kingdom 5 United States 13 Global 122

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Nanjing Rate Biochemicals CO., LTD.

Tel: +86-(0)25-84931986,(0)18951962398
Fax: +86-(0)25-84931686
Country: China
ProdList: 70
Advantage: 62

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Tianjin YongSheng Biotechnology Co., Ltd.

Tel: 022-60987737 13512258274
Fax: 86-022-23500597
Email: sales@immortalbio.com
Country: China
ProdList: 154
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Beijing Universal Century Technology Co., Ltd.

Tel: 400-8706899
Fax: 400-8706899
Email: hysj_bj.com
Country: China
ProdList: 3583
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Quzhou AMK BioTech Co., Ltd

Tel: 0570-3081766 18357083060
Fax: 0570-3072337
Email: sales@qzamkbio.com
Country: China
ProdList: 1051
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9722
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Fluoropharm Co., Ltd.

Tel: 0571-85586753 13336034509
Fax: 0571 85586753
Email: sales@fluoropharm.com
Country: China
ProdList: 1289
Advantage: 58

Henan's chemical products co., LTD

Tel: 0371-60919097 15378766539
Fax: 0371-60919097
Email: 794449696@qq.com
Country: China
ProdList: 4996
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9972
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

changzhou ansciep chemical co., ltd.

Tel: 0519-86305871 13961213398;
Fax: 0519-86305879
Email: tina@ansciepchem.com
Country: China
ProdList: 500
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Shanghai FWD Chemicals Limited

Tel: 021-54450827 021-54450828
Email: sales@fwdchem.com
Country: China
ProdList: 998
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: +86-021-56795779 +8613651600618
Email: sales@worldyachem.com
Country: China
ProdList: 969
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10000
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Suzhou QIHANG Biotechnology Co., Ltd

Tel: 18662190603
Email: 437347250@qq.com
Country: China
ProdList: 4674
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9921
Advantage: 58

Less

View Lastest Price from Methyl 3-amino-5-chloro-2-hydroxybenzoate manufacturers

Career Henan Chemical Co

Product: Methyl 3-amino-5-chloro-2-hydroxybenzoate 5043-81-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

5043-81-2, Methyl 3-amino-5-chloro-2-hydroxybenzoate Related Search:

6-Aminocaproic acid Methyl 3-hydroxybenzoate Methyl acetate 3-Hydroxybenzoic acid 4-Aminobenzoic acid Glycine Methyl benzoate Kresoxim-methyl Methyl acrylate Salicylic acid Bensulfuron methyl 4-Hydroxybenzoic acid Methylparaben Thiophanate-methyl Methyl Anthranilic acid Difluorochloromethane Methyl bromide

3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID METHYL ESTER

methyl 3-amino-5-chloro-2-hydroxybenzoate

Methyl 3-amino-5-chlorosalicylate

3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID ME ESTER

3-amino-5-chloro-2-hydroxybenzoate

3-Amino-5-chloro-salicylic Acid Methyl Ester

SALICYLICACID,3-AMINO-5-CHLORO-,METHYLESTER(7CI,8CI)

methyl 3-amino-5-chloro-2-hydroxybenzoate hydrochloride

Benzoic acid, 3-amino-5-chloro-2-hydroxy-, methyl ester

Azasetron Impurity 10

5043-81-2

C8H9ClNO3

C8H8ClNO3ClH

Amines

Aromatics

Intermediates

Benzoic acid