Methyl 3-amino-5-chloro-2-hydroxybenzoate
- Product Name
- Methyl 3-amino-5-chloro-2-hydroxybenzoate
- CAS No.
- 5043-81-2
- Chemical Name
- Methyl 3-amino-5-chloro-2-hydroxybenzoate
- Synonyms
- Azasetron Impurity 10;Methyl 3-amino-5-chlorosalicylate;3-amino-5-chloro-2-hydroxybenzoate;methyl 3-amino-5-chloro-2-hydroxybenzoate;3-Amino-5-chloro-salicylic Acid Methyl Ester;3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID ME ESTER;3-AMINO-5-CHLORO-2-HYDROXYBENZOIC ACID METHYL ESTER;SALICYLICACID,3-AMINO-5-CHLORO-,METHYLESTER(7CI,8CI);Benzoic acid, 3-amino-5-chloro-2-hydroxy-, methyl ester;methyl 3-amino-5-chloro-2-hydroxybenzoate hydrochloride
- CBNumber
- CB7367265
- Molecular Formula
- C8H8ClNO3
- Formula Weight
- 201.61
- MOL File
- 5043-81-2.mol
Methyl 3-amino-5-chloro-2-hydroxybenzoate Property
- Melting point:
- 71-73°C
- Boiling point:
- 322.0±42.0 °C(Predicted)
- Density
- 1.440±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.11±0.23(Predicted)
- form
- Solid
- color
- Pale Brown to Brown
- CAS DataBase Reference
- 5043-81-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A603330
- Product name
- 3-Amino-5-chloroSalicylicAcidMethylEster
- Packaging
- 2g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- A603330
- Product name
- 3-Amino-5-chloroSalicylicAcidMethylEster
- Packaging
- 10g
- Price
- $1070
- Updated
- 2021/12/16
- Product number
- FA17619
- Product name
- 3-Amino-5-chloro salicylic acid methyl ester
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 157512
- Product name
- Methyl 3-amino-5-chloro-2-hydroxybenzoate hydrochloride
- Packaging
- 0.500g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FA17619
- Product name
- 3-Amino-5-chloro salicylic acid methyl ester
- Packaging
- 1g
- Price
- $199.9
- Updated
- 2021/12/16
Methyl 3-amino-5-chloro-2-hydroxybenzoate Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
Intermediate in the preparation of Azasetron.
Synthesis
5043-79-8
5043-81-2
General procedure for the synthesis of methyl 3-amino-5-chloro-2-hydroxy-2-hydroxybenzoate from methyl 5-chloro-2-hydroxy-3-nitrobenzoate: Methyl 5-chloro-2-hydroxy-3-nitrobenzoate (2.00 g, 10.7 mmol) was dissolved in 6 mL of concentrated sulfuric acid and stirred at 0 °C. Subsequently, a mixture of concentrated sulfuric acid and concentrated nitric acid (1:1, 1.6 mL, v/v) was slowly added, and the reaction mixture was gradually warmed up to room temperature with continuous stirring for 24 hours. After the reaction was completed, the mixture was poured into ice water, the precipitate was collected by filtration, washed with water and dried to obtain the nitro compound. The nitro compound was suspended in a solvent mixture of 15 mL of ethyl acetate and 15 mL of methanol, 5% palladium/carbon catalyst (0.350 g) was added, and the hydrogenation reduction reaction was carried out at room temperature for 4 hours. At the end of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford methyl 3-amino-5-chloro-2-hydroxybenzoate solid 1.61 g in 74.6% yield. The product was characterized by 1H-NMR (CDCl3): δ 10.84 (1H, s), 7.20 (1H, d, J=2.4Hz), 6.83 (1H, d, J=2.4Hz), 3.94 (3H, s).
References
[1] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 3, p. 624 - 630
[2] Patent: JP2016/56134, 2016, A. Location in patent: Paragraph 0245; 0246; 0247
[3] Patent: US2014/275172, 2014, A1. Location in patent: Paragraph 0945
Methyl 3-amino-5-chloro-2-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-amino-5-chloro-2-hydroxybenzoate Suppliers
- Tel
- --
- Fax
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- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
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View Lastest Price from Methyl 3-amino-5-chloro-2-hydroxybenzoate manufacturers
- Product
- Methyl 3-amino-5-chloro-2-hydroxybenzoate 5043-81-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11