ChemicalBook > CAS DataBase List > 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

Product Name
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
CAS No.
124011-52-5
Chemical Name
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
Synonyms
1,2-Distearoyl-rac-glycero-3-PG (sodium salt);1,2-distearoyl phosphatidylglycerol (sodium salt);1,2-Distearoyl-sn-glycero-3-phosphoglycerol sodium;1,2-Distearoyl-rac-glycero-3-PG (sodium salt) dspg;1, 2-distearoyl-sn-glycero-3-phospho-(1-rac-glycerol);DSPG-NA 1,2-distearoyl phosphatidylglycerol (sodium salt);1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, SALT;(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT;sodium 2,3-bis(stearoyloxy)propyl (2,3-dihydroxypropyl) phosphate
CBNumber
CB7380181
Molecular Formula
C42H84NaO10P
Formula Weight
803.09
MOL File
124011-52-5.mol
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1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Property

solubility 
Chloroform:2.0(Max Conc. mg/mL);2.5(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15087
Product name
1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
Purity
≥98%
Packaging
100 mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
15087
Product name
1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
Purity
≥98%
Packaging
250 mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
15087
Product name
1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
Purity
≥98%
Packaging
500 mg
Price
$368
Updated
2024/03/01
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1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Chemical Properties,Usage,Production

Description

DSPG is used in FDA approved drugs. It is an anionic phospholipid derivative. DSPG has been used to form an ionic complex with amphotericin B and encapsulate it into small unilamellar liposomes with significantly reduced toxicity (AmBisome?). DSPG-Na is a lipid reagent, which is useful in drug formulation, DNA & RNA delivery.

Uses

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be used for drug delivery and the synthesis of liposomes[1].

in vitro

Three liposome formulations were investigated: HSPC:Chol (L-EPI; 5:4 molar ratio), HSPC:Chol:DSPG (D-EPI; 5:4:1 molar ratio), and HSPC:Chol:DSPG:DSPE-mPEG(2000) (S-EPI; 5:4:1:0.3 molar ratio). Small unilamellar liposomes were prepared by the modified thin-film hydration method with extrusion through polycarbonate filters, and EPI was remote loaded into liposomes by the transmembrane ammonium sulfate gradient method._x000D_ _x000D_ Reference: J Liposome Res. 2012 Mar;22(1):80-8. https://pubmed.ncbi.nlm.nih.gov/22022836/

in vivo

Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis._x000D_ _x000D_ Reference: J Control Release. 2018 Dec 10;291:135-146. https://pubmed.ncbi.nlm.nih.gov/30365993/

target

A phospholipid.

References

[1] Naomi Benne, et al. Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice. J Control Release. 2018 Dec 10;291:135-146. DOI:10.1016/j.jconrel.2018.10.028

1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Suppliers

China 43 Sweden 1 United Kingdom 1 United States 6 Global 51
Suzhou Highfine Biotech Co., Ltd
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0512-69209928 18796809688
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0512-68417696
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zhouyingxiang@highfine.com
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China
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
Email
info@chemlin.com.cn
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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Yichang Zhongyitai Trading Co., Ltd.
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0717-6449896 13886658719
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0717-6558598
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Wellman Pharmaceutical Group Limited
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027-027-83778875 15807197853
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027-83991220
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15807197853@163.com
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Shanghai Zhen Li Biological Technology Co., Ltd
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021-16621358918; 18516310516
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13045646768
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zhenlipharma888@163.com
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China
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19035
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Suzhou C1 Technology Co.，Ltd
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18606219109
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ty.sales1@feixiangchem.com
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China
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Beijing Minruida Technology Co., Ltd.
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010-82387566 18001021521;
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82387566-801
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sales@mreda.com.cn
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China
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10083
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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1886
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Shochem(Shanghai)Co.,Ltd
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info@shochem.com
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124011-52-5, 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALTRelated Search:

Cholesterol 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDIC ACID, SODIUM SALT 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL, SODIUM SALT 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE (MONOSODIUM SALT) 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Distearoyl-sn-glycero-3-phosphocholine 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy-(2,3-dihydroxypropoxy)phosphinic acid 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE POPC 1,2-DI13-CIS-DOCOSENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIHEXADECANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)] SODIUM SALT 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

  • 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
  • 1,2-distearoyl-sn-glycero-3-phosphatidyl-rac-glycerol sodium salt
  • Octadecanoic acid,1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester,sodium salt
  • 1,2-Distearoyl-rac-glycero-3-PG (sodium salt)
  • sodium 2,3-bis(stearoyloxy)propyl (2,3-dihydroxypropyl) phosphate
  • (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium
  • DSPG-NA 1,2-distearoyl phosphatidylglycerol (sodium salt)
  • 1,2-Distearoyl-sn-glycero-3-phosphoglycerol sodium
  • 1,2-distearoyl phosphatidylglycerol (sodium salt)
  • 3-(((2,3-Dihydroxypropoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate, sodium salt(1:x)
  • (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) - [D91309]
  • 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, SALT
  • 1, 2-distearoyl-sn-glycero-3-phospho-(1-rac-glycerol)
  • 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) dspg
  • 124011-52-5