ChemicalBook > CAS DataBase List > 5-Fluorosalicylaldehyde

5-Fluorosalicylaldehyde

Product Name
5-Fluorosalicylaldehyde
CAS No.
347-54-6
Chemical Name
5-Fluorosalicylaldehyde
Synonyms
5-FLUORO-2-HYDROXYBENZALDEHYDE;5-FLUOROSALICYLALDEHYDE;5-FluoroSalicylicAldehyde;5-Fluorosalicylaldehyde>5-Fluorosalicylaldehyde 97%;5-FLUORO-2-HYDROXYBENZALDEHY;5-Fluorosalicylaldehyde, 98+%;5-Fluorosalicylaldehyde, 97%,;Benzaldehyde, 5-fluoro-2-hydroxy-;5-Fluoro-2-hydroxybenzaldehyde,97%
CBNumber
CB7388152
Molecular Formula
C7H5FO2
Formula Weight
140.11
MOL File
347-54-6.mol
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5-Fluorosalicylaldehyde Property

Melting point:
82-85 °C (lit.)
Boiling point:
56 °C / 1mmHg
Density 
1.350±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
8.18±0.18(Predicted)
form 
Powder or Flakes
color 
White to Orange to Green
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H5FO2/c8-6-1-2-7(10)5(3-6)4-9/h1-4,10H
InChIKey
FDUBQNUDZOGOFE-UHFFFAOYSA-N
SMILES
C(=O)C1=CC(F)=CC=C1O
CAS DataBase Reference
347-54-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
526274
Product name
5-Fluorosalicylaldehyde
Purity
97%
Packaging
1g
Price
$82.6
Updated
2025/07/31
TCI Chemical
Product number
F0574
Product name
5-Fluorosalicylaldehyde
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
F0574
Product name
5-Fluorosalicylaldehyde
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$206
Updated
2025/07/31
TRC
Product number
F598075
Product name
5-Fluoro-2-hydroxybenzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
C229
Product name
5-Fluoro-2-hydroxybenzaldehyde
Packaging
1g
Price
$14
Updated
2021/12/16
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5-Fluorosalicylaldehyde Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

5-Fluorosalicylaldehyde may be used to synthesize:

  • managanese (III) complex [MnLa(μ1,3-N3)]n [H2La = N,N′-bis(5-fluorosalicylidene)-1,2-diaminoethane]
  • enantiopure 4-amino-6-fluoro-3-(hydroxymethyl)chromanes
  • 4,4′-difluoro-2,2′-[(hydrazine-1,2-diylidene)bis(methanylylidene)]-diphenol
  • N,N′-bis(5-fluoro-2-hydroxybenzylidene)ethylenediamine
  • N,N′-(2-hydroxypropane-1,3-diyl)-bis(salicylaldimine (H2L)

General Description

5-Fluorosalicylaldehyde can be synthesized from 4-fluorophenol.

Synthesis

371-41-5

67-66-3

347-54-6

The general procedure for the synthesis of 5-fluorosalicylaldehyde from 4-fluorophenol and trichloromethane is as follows: Step A: To a solution of water (400mL) containing NaOH (78g, 1950mmol) was added a mixture of 4-fluorophenol (50g, 446.43mmol) in water (200mL) and ethanol (150mL). After heating the mixture to 70°C, trichloromethane (110 mL) was slowly added dropwise through the addition funnel (approximately 2 hours to complete the drop) and the reaction mixture was continuously stirred at this temperature overnight (approximately 16 hours). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 3M HCl solution. Subsequently, the reaction mixture was partitioned between saturated saline and dichloromethane, the organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent: 3% ethyl acetate/hexane) to afford 13.6 g of 5-fluorosalicylaldehyde (22% yield, white solid).

References

[1] Journal of the American Chemical Society, 1998, vol. 120, # 33, p. 8340 - 8347
[2] Patent: WO2005/37763, 2005, A1. Location in patent: Page/Page column 126
[3] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0372; 0373; 0374
[4] Journal of the American Chemical Society, 1946, vol. 68, p. 2502
[5] European Journal of Medicinal Chemistry, 1996, vol. 31, # 6, p. 449 - 460

5-Fluorosalicylaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluorosalicylaldehyde Suppliers

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View Lastest Price from 5-Fluorosalicylaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Fluorosalicylaldehyde 347-54-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-15
Qingdao RENAS Polymer Material Co., Ltd.
Product
5-Fluoro-2-hydroxybenzaldehyde 347-54-6
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-10-08
Hebei Yanxi Chemical Co., Ltd.
Product
5-Fluorosalicylaldehyde 347-54-6
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-17

347-54-6, 5-FluorosalicylaldehydeRelated Search:

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