Sodium Butyrate
- Product Name
- Sodium Butyrate
- CAS No.
- 156-54-7
- Chemical Name
- Sodium Butyrate
- Synonyms
- NAB;SODIUM BUTANOATE;SODIUM N-BUTYRATE;BUTYRIC ACID SODIUM SALT;N-BUTYRIC ACID SODIUM SALT;Sodium Butyrate - CAS 156-54-7 - Calbiochem;Natriumbutyrat;butyratesodium;SODIUM BUTYRATE;BUTYRIC ACID NA
- CBNumber
- CB7391358
- Molecular Formula
- C4H7NaO2
- Formula Weight
- 110.09
- MOL File
- 156-54-7.mol
Sodium Butyrate Property
- Melting point:
- 250-253 °C (lit.)
- Density
- 1.324 g/cm3 (30℃)
- storage temp.
- Store below +30°C.
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Amorphous Powder
- color
- White
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3629439
- Stability:
- Stable. Incompatible with strong acids.
- InChI
- InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
- InChIKey
- MFBOGIVSZKQAPD-UHFFFAOYSA-M
- SMILES
- C(CC)C([O-])=O.[Na+]
- LogP
- 0.777 (est)
- CAS DataBase Reference
- 156-54-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Sodium butyrate(156-54-7)
- EPA Substance Registry System
- Butanoic acid, sodium salt (156-54-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-68
- Safety Statements
- 37/39-26-24/25-36/37
- RTECS
- ET6400000
- F
- 3-10
- HS Code
- 29156000
- Hazardous Substances Data
- 156-54-7(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.20236
- Product name
- Sodium butyrate
- Purity
- for synthesis
- Packaging
- 250g
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 8.20236
- Product name
- Sodium butyrate
- Purity
- for synthesis
- Packaging
- 1kg
- Price
- $519
- Updated
- 2024/03/01
- Product number
- 8.17500
- Product name
- Sodium butyrate
- Purity
- special quality
- Packaging
- 100g
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 1613600
- Product name
- Sodium butyrate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 07596
- Product name
- Sodium butyrate
- Purity
- certified reference material, TraceCERT
- Packaging
- 100mg
- Price
- $127
- Updated
- 2024/03/01
Sodium Butyrate Chemical Properties,Usage,Production
Chemical Properties
Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.
Uses
Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.
Uses
Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.
Definition
ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.
benefits
Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.
Biological Activity
Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.
Biochem/physiol Actions
Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.
storage
Room temperature
Purification Methods
Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]
Sodium Butyrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sodium Butyrate manufacturers
- Product
- Sodium Butyrate 156-54-7
- Price
- US $999.00-666.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-13
- Product
- Sodium Butyrate 156-54-7
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-07
- Product
- Sodium Butyrate 156-54-7
- Price
- US $9.80-6.60/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 10 tons
- Release date
- 2024-06-21