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Sodium Butyrate

Product Name
Sodium Butyrate
CAS No.
156-54-7
Chemical Name
Sodium Butyrate
Synonyms
NAB;SODIUM BUTANOATE;SODIUM N-BUTYRATE;BUTYRIC ACID SODIUM SALT;N-BUTYRIC ACID SODIUM SALT;Sodium Butyrate - CAS 156-54-7 - Calbiochem;Natriumbutyrat;butyratesodium;SODIUM BUTYRATE;BUTYRIC ACID NA
CBNumber
CB7391358
Molecular Formula
C4H7NaO2
Formula Weight
110.09
MOL File
156-54-7.mol
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Sodium Butyrate Property

Melting point:
250-253 °C (lit.)
Density 
1.324 g/cm3 (30℃)
storage temp. 
Store below +30°C.
solubility 
Methanol (Slightly), Water (Slightly)
form 
Amorphous Powder
color 
White
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3629439
Stability:
Stable. Incompatible with strong acids.
InChI
InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChIKey
MFBOGIVSZKQAPD-UHFFFAOYSA-M
SMILES
C(CC)C([O-])=O.[Na+]
LogP
0.777 (est)
CAS DataBase Reference
156-54-7(CAS DataBase Reference)
NIST Chemistry Reference
Sodium butyrate(156-54-7)
EPA Substance Registry System
Butanoic acid, sodium salt (156-54-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-68
Safety Statements 
37/39-26-24/25-36/37
RTECS 
ET6400000
F 
3-10
HS Code 
29156000
Hazardous Substances Data
156-54-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20236
Product name
Sodium butyrate
Purity
for synthesis
Packaging
250g
Price
$148
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20236
Product name
Sodium butyrate
Purity
for synthesis
Packaging
1kg
Price
$519
Updated
2024/03/01
Sigma-Aldrich
Product number
8.17500
Product name
Sodium butyrate
Purity
special quality
Packaging
100g
Price
$64
Updated
2024/03/01
Sigma-Aldrich
Product number
1613600
Product name
Sodium butyrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
07596
Product name
Sodium butyrate
Purity
certified reference material, TraceCERT
Packaging
100mg
Price
$127
Updated
2024/03/01
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Sodium Butyrate Chemical Properties,Usage,Production

Chemical Properties

Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.

Uses

Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Uses

Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.

Definition

ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.

benefits

Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

storage

Room temperature

Purification Methods

Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]

Sodium Butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

Benzyl butyrate Iopanoic acid Butyric anhydride 2-(4-isobutylphenyl)propionaldehyde 2-(4-isobutylphenyl)propionaldehyde oxime 2-(m-aminobenzyl)butyric acid ALLYL 2-ETHYLBUTYRATE ACETOACETIC ACID N-BUTYL ESTER
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Sodium Butyrate Suppliers

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View Lastest Price from Sodium Butyrate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Sodium Butyrate 156-54-7
Price
US $999.00-666.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sodium Butyrate 156-54-7
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-07
Shandong Deshang Chemical Co., Ltd.
Product
Sodium Butyrate 156-54-7
Price
US $9.80-6.60/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
10 tons
Release date
2024-06-21

156-54-7, Sodium ButyrateRelated Search:

Sodium hyaluronate Sodium percarbonate Sodium silicate Sodium hydroxide Sodium bicarbonate Sodium carbonate Butyric Acid Sodium chlorite Sodium chloride Trisodium citrate dihydrate Methyl butyrate Sodium acetate Sodium formate 3beta-Hydroxy-5-cholestene 3-butyrate Diclofenac sodium Sodium benzoate 2-Butoxyacetic acid n-Butylboronic acid

  • Sodium Butyrate - CAS 156-54-7 - Calbiochem
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