ChemicalBook > CAS DataBase List > Sparfloxacin

Sparfloxacin

Product Name
Sparfloxacin
CAS No.
110871-86-8
Chemical Name
Sparfloxacin
Synonyms
Parox;Zagam;ci978;Spara;at4140;Sparcin;RP-64206;CP 103826;PD 1315-1;Sparfloxacin
CBNumber
CB7407291
Molecular Formula
C19H22F2N4O3
Formula Weight
392.4
MOL File
110871-86-8.mol
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Sparfloxacin Property

Melting point:
265°C
Boiling point:
640℃
Density 
1.436±0.06 g/cm3(Predicted)
Flash point:
>110°(230°F)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml
pka
pKa1 6.25, pKa2 9.30(at 25℃)
form 
powder
color 
white to light yellow
biological source
synthetic
Water Solubility 
Soluble in DMSO at 9mg/ml. Sparingly soluble in water
BRN 
9170271
CAS DataBase Reference
110871-86-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
VB1986500
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
56968
Product name
Sparfloxacin
Purity
≥98.0% (HPLC)
Packaging
1G
Price
$64.7
Updated
2024/03/01
Sigma-Aldrich
Product number
56968
Product name
Sparfloxacin
Purity
≥98.0% (HPLC)
Packaging
10G
Price
$190
Updated
2024/03/01
Alfa Aesar
Product number
J66358
Product name
Sparfloxacin
Purity
98%
Packaging
1g
Price
$32.7
Updated
2024/03/01
Alfa Aesar
Product number
J66358
Product name
Sparfloxacin
Purity
98%
Packaging
10g
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
20379
Product name
Sparfloxacin
Purity
≥95%
Packaging
1g
Price
$32
Updated
2024/03/01
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Sparfloxacin Chemical Properties,Usage,Production

Description

Sparfloxacin is the most potent fluoroquinolone antibiotic introduced for the treatment of community acquired infections. It has superior and broad in vitro activity against members of family Enterobacferiaceae and anaerobic bacteria, some of which are resistant toβ-lactam antibiotics or to aminoglycosides. In patients with surgical infections, sparfloxacin shows excellent activity against resistant pathogens. It is effective in treating patients with bladder irritability and is reported to have potential in the treatment of leprosy and Mycobacterium tuberculosis in mice. Favorable pharmacokinetic properties, good intracellular penetration and a lack of transferable resistance have been reported.

Chemical Properties

Light yellow powder

Originator

Dainippon (Japan)

Uses

antifungal

Uses

A fluorianted quinolone antibacterial.

Definition

ChEBI: Sparfloxacin is a quinolone, a quinolinemonocarboxylic acid, a N-arylpiperazine, a quinolone antibiotic and a fluoroquinolone antibiotic.

Manufacturing Process

A mixture of the known compound, ethyl pentafluorobenzoylacetate [J. Org. Chem., 35, 930 (1970)] (25 g), ethyl orthoformate (20 g), and acetic anhydride (23 g) was refluxed for 2 h. The reaction mixture was evaporated to dryness under reduced pressure. The residue was dissolved in diethyl ether and allowed to react with cyclopropylamine (5.1 g) to give ethyl 2- pentafluorobenzoyl-3-cyclopropylaminoacrylate (28 g), melting point 89°C.
The ethyl 2-pentafluorobenzoyl-3-cyclopropylaminoacrylate (28 g) was dissolved in dry tetrahydrofuran and allowed to react with 60% sodium hydride (3.85 g) at room temperature to give ethyl 1-cyclopropyl-5,6,7,8- tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (18.4 g), melting point 170°-171°C.
A mixture of ethyl 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4- oxoquinoline-3-carboxylate (28.2 g), benzylamine (9.8 ml), anhydrous potassium carbonate (23.6 g), and acetonitrile (140 ml) was heated at 100°- 110°C for 1 h to give ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4- dihydro-4-oxoquinoline-3-carboxylate (21.4 g), which was recrystallized from ethanol, melting point 134°-135°C.
The ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylate (20 g) was dissolved in acetic acid (100 ml) and ethanol (150 ml), and hydrogenolyzed in the presence of 5% palladiumcarbon (0.5 g) to give ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro- 4-oxoquinoline-3-carboxylate (14.1 g), which was recrystallized from chloroform-ethanol, melting point 236°-237°C.
A mixture of the ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylate (12.6 g), acetic acid (80 ml), water (50 ml), and concentrated sulfuric acid (9 ml) was heated at 100°-110°C for 40 min to give 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (11.1 g), which was recrystallized from chloroform-ethanol, melting point 294°-295°C.
A mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid (1.25 g), cis-2,6-dimethylpiperazine (2.0 g), and dimethylformamide was stirred at room tempersture for 24 h. The reaction mixture was evaporated to dryness under reduced pressure and water was added to the residue. The mixture was extracted with chloroform and the extract was dried. After evaporation of chloroform, ethanol was added to the residue. The resulting crystals were filtered and recrystallized from chloroform-ethanol to give 5-amino-1-cyclopropyl-6,8-difluoro-7-(cis-3,5- dimethyl-1-piperazinyl)-1,4-dihydro- 4-oxoquinoline-3-carboxylic acid (1.4 g), melting point: 258°-260°C.

brand name

Zagam (Mylan);Spara.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sparfloxacin is a quinolone antimicrobial agent. See also under quinolone and fluoroquinolone antimicrobial agents.

Pharmaceutical Applications

It is highly active against most aerobic Grampositive cocci and Gram-negative bacilli, including fastidious Gram-negative bacilli, Acinetobacter spp., Campylobacter spp. and Legionella spp. Ps. aeruginosa is weakly susceptible. Activity also extends to the genital mycoplasmas, M. tuberculosis and M. avium complex isolates. It is moderately active against some anaerobes (including the B. fragilis group); L. monocytogenes is resistant.
It is well absorbed, achieving a plasma concentration of 1–1.5 mg/L 4.5 h after a 400 mg oral dose. Absorption is decreased in the presence of antacids owing to the formation of chelates with metallic ions. Concentrations in many tissues, including lung, exceed those in plasma. The plasma half-life is 15–20 h. CSF penetration is limited. Around 5–10% of a dose is eliminated unchanged in the urine, with about 30% appearing as the glucuronide. Total clearance is 10–15 L/h. The plasma half-life increases only modestly in renal failure to 30–40 h. About 50–60% of the dose appears as unchanged drug in the feces, mainly as the glucuronide, accounting for 10–20% of the administered dose.
Adverse events are those common to fluoroquinolones, in particular gastrointestinal tract disturbances, CNS effects (mainly headache and insomnia) and rashes. Photosensitivity reactions have been observed in 2–11% of patients. It can prolong the QTc interval and cases of torsade de pointes have been reported. It does not potentiate the toxicity of theophylline.
It has been used for respiratory and other infections caused by susceptible bacteria, but use has been restricted in the USA and Europe because of phototoxicity and cardiotoxicity.

Clinical Use

Sparfloxacin, (cis)-5-amino-1-cyclopropyl-7-(3,5-dimethyl)-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid, is a newer fluoroquinolone.
This compound exhibits higher potency against Grampositivebacteria, especially staphylococci and streptococci,than the fluoroquinolones currently marketed. It is also moreactive against chlamydia and the anaerobe Bacteroides fragilis.The activity of sparfloxacin against Gram-negative bacteriais also very impressive, and it compares favorably withciprofloxacin and ofloxacin in potency against Mycoplasmaspp., Legionella spp., Mycobacteria spp., and Listeria monocytogenes.Sparfloxacin has a long elimination half-life of18 hours, which permits once-a-day dosing for most indications.The drug is widely distributed into most fluidsand tissues. Effective concentrations of sparfloxacin areachieved for the treatment of skin and soft tissue infections,lower respiratory infections (including bronchitis and bacterialpneumonias), and pelvic inflammatory disease causedby gonorrhea and chlamydia. Sparfloxacin has also beenrecommended for the treatment of bacterial gastroenteritisand cholecystitis. The oral bioavailability of sparfloxacinis claimed to be good, and sufficient unchanged drug isexcreted to be effective for the treatment of urinary tract infections.Nearly 20% of an orally administered dose is excretedas an inactive glucuronide.

Sparfloxacin Preparation Products And Raw materials

Raw materials

Magnesium strip Concentrated hydrochloric acid Cyclopropylamine Iron mud 2,3,4,5-Tetrafluorobenzoic acid CHLOROETHANE Tetrahydrofuran weak Nitric acid Thionyl chloride Sodium carbonate

Preparation Products

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Sparfloxacin Suppliers

Austria 1 Belgium 1 Brazil 1 Canada 5 China 242 Europe 2 Germany 6 India 63 Nepal 1 Nigeria 1 Poland 1 South Korea 1 Switzerland 2 United Kingdom 12 United States 38 Global 377
TCI Chemicals (India) Pvt. Ltd.
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View Lastest Price from Sparfloxacin manufacturers

Henan Xiangtong Chemical Co., Ltd.
Product
Sparfloxacin 110871-86-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10T
Release date
2019-11-20
Dideu Industries Group Limited
Product
Sparfloxacin 110871-86-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-19
Career Henan Chemical Co
Product
Sparfloxacin 110871-86-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
100kg
Release date
2020-01-10

110871-86-8, SparfloxacinRelated Search:

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  • Sparfloxacin Solution, 100ppm
  • Sparfloxacin solution,1000ppm
  • 5-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3α,5α-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid
  • 5-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3β,5β-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid
  • RP-64206
  • 5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • Sparfloxacin
  • Sparfloxacine
  • cis-5-AMino-1-cyclopropyl-7-(3,5-diMethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
  • Parox
  • Sparcin
  • AT-4140,CI-978,PD 131501
  • rel-5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • (cis)-5-Amino-1-cyclopropyl-6，8-difluoro-1，4-dihydro-7-(3，5-dimethyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • PD-131501：Spara
  • 5-AMINO-1-CYCLOHEXYL-7-(CIS-3,5-DIMETHYLPIPERAZINO)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID
  • ,5-dimethyl-1-piperazinyl)-4-oxo-,cis-
  • at4140
  • ci978
  • Clorsulon, Vetranal
  • SPARFLOXACIN, [2-14C]- 5-25 MCI(185-925 MBQ)/MMOL, DELIVERED &gt
  • 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-
  • 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-, rel- (9CI)
  • CP 103826
  • PD 1315-1
  • Spara
  • Zagam
  • Sparfloxacin (base and/or unspecified salts)
  • SOYISOFLAVONES
  • 5-AMINO-1-CYCLOPROPYL-7-((3S,5R)-3,5-DIMETHYLPIPERAZIN-1-YL)-6,8-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
  • CI-978， AT-4140
  • 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-, rel-
  • 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
  • Department of mpa of sand
  • Sparfloxacin,CI978,Inhibitor,inhibit,Antibiotic,AT 4140,Bacterial,AT4140,CI 978
  • Esparfloxacino
  • Lysine Impurity 14-d9
  • Sparfloxacin in Methanol
  • C16972650 Sparfloxacin
  • Sparfloxacin, Fluoroquniolone antibiotic agent
  • Sparfloxacin, 10 mM in DMSO
  • 110871-86-8
  • 3924
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