Eltanolone

ChemicalBook > CAS DataBase List > Eltanolone

Product Name: Eltanolone
CAS No.: 128-20-1
Chemical Name: Eltanolone
Synonyms: SKF 6455;Kabi2213;NSC 82867;Kabi 2213;Kabi-2213;ELTANOLONE;PREGNANOLONE;Pregnanolone II;EPIPREGNANOLONE;3α,5β-Pregnanolone
CBNumber: CB7407837
Molecular Formula: C21H34O2
Formula Weight: 318.49
MOL File: 128-20-1.mol

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Eltanolone Property

Melting point:: 149°C
alpha: D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)
Boiling point:: 397.64°C (rough estimate)
Density: 1.0234 (rough estimate)
refractive index: 1.5344 (estimate)
storage temp.: Store at RT
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka: 15.12±0.70(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 8mg/L(room temperature)
NIST Chemistry Reference: 3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

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Safety

Hazard Codes: Xn
Risk Statements: 40
Safety Statements: 22-36
WGK Germany: 3
RTECS: TU4384000
Toxicity: LD50 in mice, rats (mg/kg): 66 ± 10, 27.5 ± 2.4 i.v. (Gyermek)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H351Suspected of causing cancer
Precautionary statements: P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8129
Product name: 5β-Pregnan-3α-ol-20-one
Packaging: 25mg
Price: $313
Updated: 2024/03/01

TRC

Product number: P711300
Product name: 5β-Pregnan-3α-ol-20-one
Packaging: 25mg
Price: $430
Updated: 2021/12/16

TRC

Product number: P711300
Product name: 5β-Pregnan-3α-ol-20-one
Packaging: 10mg
Price: $185
Updated: 2021/12/16

ApexBio Technology

Product number: B7455
Product name: 1-((3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
Packaging: 50mg
Price: $223
Updated: 2021/12/16

IsoSciences

Product number: 13398
Product name: Pregnanolone
Purity: ≥98%
Packaging: 1mg
Price: $239
Updated: 2021/12/16

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Eltanolone Chemical Properties,Usage,Production

Uses

A hyponotic-anaesthetic agent.

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT

Eltanolone Preparation Products And Raw materials

Raw materials

Preparation Products

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128-20-1, EltanoloneRelated Search:

N-Vinyl-2-pyrrolidone Polyvinylpyrrolidone N-Methyl-2-pyrrolidone 1-Octacosanol Pregnanolone-[d5] (Solution) Pregnenolone Gestrinone 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Gestodene (Z)-Guggulsterone GUGGULSTERONE E (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one Progesterone 16-Dehydropregnenolone acetate 1-Triacontanol 5B-PREGNAN-3A-OL-20-ONE-17,21,21,21-D4 Renanolone Allopregnanolone

3alpha,5beta-Epimeric pregnanolone

3alpha,5beta-Pregnanolone

3-alpha-hydroxy-5-beta-pregnan-20-on

Pregnan-20-one, 3-hydroxy-, (3a,5b)-

Pregnan-3α-ol-20-one

3a,5b-Epimeric pregnanolone

1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

5B-Pregnan-3α-ol-20-one

(3α,5β)-3-Hydroxy-pregnan-20-one

3-Deoxo-3α-hydroxy-5β-dihydroprogesterone

3α,5β-Pregnanolone

3α-Hydroxy-20-oxo-5β-pregnane

3α-Hydroxy-5β-tetrahydroprogesterone

NSC 82867

5beta-Pregnan-20-one, 3alpha-hydroxy-

5-Pregnan-3-ol-20-one

5BETA-PREGNAN-3ALPHA-OL-20-ONE

5B-PREGNAN-3A-OL-20-ONE

3ALPHA-HYDROXY-5BETA-PREGNAN-20-ONE

3ALPHA-HYDROXY-5BETA-TETRAHYDRO-PROGESTERONE

3A-HYDROXY-5B-PREGNAN-20-ONE

3a,5b-epimeric pregnanolone

PREGNANOLONE

PREGNAN-3A-OL-20-ONE

pregnan-3a-ol-20-one

Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-

Pregnan-3alpha-ol-20-one

Pregnanolone II

SKF 6455

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ELTANOLONE

5A-PREGNAN-3SS-OL-20-ONE

5A-PREGNAN-3B-OL-20-ONE ENTERPRISE STANDARD,98+%

5A-PREGNAN-3A-OL-20-ONE

3α-Hydroxy-5β-pregnan-20-one, 3α-Hydroxy-5β-tetrahydroprogesterone, Pregnanolone

3a,5b-Tetrahydroprogesterone

3a-Hydroxy-5b-tetrahydroprogesterone

Pregnanolone (Solution)

5β-Pregnan-3α-ol-20-one

5beta-Pregnan-3a-ol-20-one

5-β-Pregnan-3a-ol-20-one

Kabi 2213

Kabi2213

Kabi-2213

Pregnan-20-one, 3-hydroxy-, (3α,5β)-

Pregnanolone-[d5] in Methanol

128-20-1

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Pharmaceutical Intermediates