Eltanolone Property

Melting point:

149°C

alpha 

D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)

Boiling point:

397.64°C (rough estimate)

Density 

1.0234 (rough estimate)

refractive index 

1.5344 (estimate)

storage temp. 

Store at RT

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

pka

15.12±0.70(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

8mg/L(room temperature)

NIST Chemistry Reference

3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

Safety

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

TU4384000

Toxicity

LD50 in mice, rats (mg/kg): 66 ± 10, 27.5 ± 2.4 i.v. (Gyermek)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P281Use personal protective equipment as required.

Eltanolone Chemical Properties,Usage,Production

Uses

A hyponotic-anaesthetic agent.

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT