ChemicalBook > CAS DataBase List > 2-Phenylquinoline

2-Phenylquinoline

Product Name
2-Phenylquinoline
CAS No.
612-96-4
Chemical Name
2-Phenylquinoline
Synonyms
830g;2-Phenylquinoline;a-Phenylquinoline;Phenylquinoline,99%;2-Phenylquinoline>Phenylquinoline, 99%;Quinoline, 2-phenyl-;2-Phenylquinoline 99%;alpha-Phenylquinoline;2-Phenylquinoline, 99+%
CBNumber
CB7408748
Molecular Formula
C15H11N
Formula Weight
205.25
MOL File
612-96-4.mol
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2-Phenylquinoline Property

Melting point:
84-85 °C (lit.)
Boiling point:
363 °C
Density 
1.1155 (rough estimate)
refractive index 
1.6550 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
4.52±0.10(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
SLIGHTLY SOLUBLE
λmax
258nm(lit.)
CAS DataBase Reference
612-96-4(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 2-phenyl-(612-96-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
299650
Product name
2-Phenylquinoline
Purity
99%
Packaging
1g
Price
$83.4
Updated
2025/07/31
Sigma-Aldrich
Product number
299650
Product name
2-Phenylquinoline
Purity
99%
Packaging
5g
Price
$396
Updated
2025/07/31
TCI Chemical
Product number
P2057
Product name
2-Phenylquinoline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$61
Updated
2025/07/31
TCI Chemical
Product number
P2057
Product name
2-Phenylquinoline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$206
Updated
2025/07/31
TRC
Product number
P321030
Product name
2-Phenylquinoline
Packaging
50mg
Price
$60
Updated
2021/12/16
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2-Phenylquinoline Chemical Properties,Usage,Production

Description

2-Phenylquinoline is the major quinoline alkaloid of Galipea iongiflora, a Bolivian plant used as treatment for cutaneous leishmaniasis. Antinociceptive properties of 2-phenylquinoline isolated from the bark of Galipea iongiflora against different models of pain in mice were evaluated.

Chemical Properties

white to light yellow crystalline powder

Uses

2-Phenylquinoline was used in quantitative structure-activity relationship (QSAR) analyses of estrogen receptor β-selective ligands.

Preparation

Synthesis of 2-phenylquinoline: Quinoline (1.0 g, 7.742 mmol) and phenyl lithium (2.30 mL, 2 M, 23.22 mmol) were reacted according to general procedure. Purification of the residue by silica gel column chromatography (EtOAc:MeOH:Et3N; 10-30:1:1 or PhMe:MeOH:Et3N; 10:1:1) gave 2-phenylquinoline (0.66 g, 42%) as an orange solid.
Aniline (0.140 g, 1.50 mmol) and cinnamaldehyde (0.132 g, 1.00 mmol) were dissolved in toluene in a reaction vial equipped with a magnetic stirrer bar, followed by the addition of K10 (0.50 g). The reaction mixture was heated at a temperature of 110 ?C for 3 hours. After completion of the reaction, the crude product was purified by column chromatography over silica gel eluting with a mixture of Hexane : Ethyl acetate (20:1) to produce 2-Phenylquinoline as a yellow solid (0.044 g, 21%); (m.p. 82-84 ?C) (lit. 84-85 °C); Rf 0.67 (20:1 hexane:ethyl acetate);
1H NMR (400 MHz, CDCl3) δH 7.46-7.51 (1H, m, H-4’), 7.53-7.56 (3H, m, H-6, 3’, 5’), 7.73- 7.77 (1H, m, H-7), 7.85 (1H, d, J = 8.31 Hz, H-5), 7.88-7.91 (1H, d, J = 8.31 Hz, H-3), 8.18- 8.27 (4H, m, H-4, 8, 2’, 6’)
13C NMR(400 MHz, CDCl3) δC 119.2 (C-3), 126.7 (C-6), 127.2 (C-4a), 127.5 (C-2’, 6’), 127.9 (C-5), 128.4 (C-3’, 5’), 128.7 (C-4’), 128.9 (C-7, 8), 129.8 (C-4), 130.3 (C-1’), 137.9 (C-8a), 157.2 (C-2)

Synthesis Reference(s)

Synthetic Communications, 23, p. 1959, 1993 DOI: 10.1080/00397919308009854
Chemical and Pharmaceutical Bulletin, 26, p. 3485, 1978 DOI: 10.1248/cpb.26.3485
Journal of the American Chemical Society, 71, p. 2327, 1949 DOI: 10.1021/ja01175a017

2-Phenylquinoline Preparation Products And Raw materials

Raw materials

Phenylmagnesium bromide Quinoline Phenyllithium Bromobenzene 1,4-Dioxane

Preparation Products

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2-Phenylquinoline Suppliers

Belgium 1 China 162 Germany 3 India 4 Japan 3 Switzerland 1 United Kingdom 5 United States 18 Global 197
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View Lastest Price from 2-Phenylquinoline manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Phenylquinoline 612-96-4
Price
US $188.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-05
Career Henan Chemical Co
Product
2-Phenylquinoline 612-96-4
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10TON
Release date
2018-12-18

612-96-4, 2-PhenylquinolineRelated Search:

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