ML193

Product Name: ML193
CAS No.: 713121-80-3
Chemical Name: ML193
Synonyms: ML193;CID 1261822;ML193 trifluoroacetate >=98% (HPLC);N-(4-(N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl)phenyl)-6,8-dimethyl-2-(pyridin-2-yl)quinoline-4-carboxamide;N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-;Inhibitor,deficits,motor,sensorimotor,CID-1261822,G protein-coupled receptor 55,disease,ML-193,Parkinson,ML193,CID1261822,ML 193,inhibit,GPR55
CBNumber: CB74199381
Molecular Formula: C28H25N5O4S
Formula Weight: 527.59
MOL File: 713121-80-3.mol

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ML193 Property

storage temp.: Store at -20°C
solubility: ≤0.1mg/ml in ethanol;2mg/ml in DMSO;3mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15184
Product name: ML-193
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15184
Product name: ML-193
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 15184
Product name: ML-193
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 15184
Product name: ML-193
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Tocris

Product number: 4860
Product name: ML193
Purity: ≥98%(HPLC)
Packaging: 10
Price: $270
Updated: 2021/12/16

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ML193 Chemical Properties,Usage,Production

Uses

ML-193 is a potent antagonist of the GPR55 receptor which has been implicated in inflammatory pain and neuropathic pain as well as metabolic disorders and cancer.

Definition

ChEBI: N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide is an aromatic amide.

Biological Activity

ml-193 is a gpr55 antagonist.gpr55 is a class a g protein-coupled receptor (gpcr) that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. initially deorphanized as a cannabinoid receptor, gpr55 has been shown to be activated by non-cannabinoid ligands such as l-α-lysophosphatidylinositol (lpi).

in vitro

previous study found that for antagonist activity in the β-arrestin trafficking assay, ml193 and its two close analogs (ml191 and ml192) could inhibit trafficking induced by 10 μm lpi with ic50 values of 0.22 ± 0.03, 1.08 ± 0.03 and 0.70 ± 0.05μm, respectively.in addition, it was also found that ml193, ml191 and ml192 was able to inhibit trafficking induced by 1 μm ml186 with ic50 values of 0.12 ±0.02, 1.03 ± 0.03 and 0.29 ± 0.09 μm, respectively [1].

in vivo

animal study showd that ml-193 was able to block the increases in intracellular calcium levels that was induced by lysophosphatidylinositol (lpi) in dissociated rat periaqueductal gray neurons and could also modulate pain perception in lpi-treated rats, suggesting that interfering with gpr55 signaling in the pag might promote analgesia [2].

IC 50

221 nm

storage

Store at -20°C

References

[1] kotsikorou, e. ,sharir, h.,shore, d.m., et al. identification of the gpr55 antagonist binding site using a novel set of high-potency gpr55 selective ligands. biochemistry 52(52), 9456-9469 (2013).
[2] deliu, e. ,sperow, m.,console-bram, l., et al. the lysophosphatidylinositol receptor gpr55 modulates pain perception in the periaqueductal gray. mol.pharmacol. 88(2), 265-272 (2015).

ML193 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML193 Suppliers

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ML193

N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-

ML193 trifluoroacetate >=98% (HPLC)

N-(4-(N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl)phenyl)-6,8-dimethyl-2-(pyridin-2-yl)quinoline-4-carboxamide

CID 1261822

Inhibitor,deficits,motor,sensorimotor,CID-1261822,G protein-coupled receptor 55,disease,ML-193,Parkinson,ML193,CID1261822,ML 193,inhibit,GPR55

713121-80-3