4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
- Product Name
- 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
- CAS No.
- 62433-26-5
- Chemical Name
- 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
- Synonyms
- SL-79-182;SL-79-182-00;4'-Chloro-5-fluoro-2-hydroxyacetophenone;4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE;4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENON&;2-Hydroxy-4'-chloro-5-fluorobenzophenone;4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE;4-CHLORO-5'-FLUORO-2'-HYDROXYBENZOPHENONE;4'-Chloro-5-fluoro-2-hydroxybenzophenone97%;(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl) ketone
- CBNumber
- CB7423264
- Molecular Formula
- C13H8ClFO2
- Formula Weight
- 250.65
- MOL File
- 62433-26-5.mol
4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Property
- Melting point:
- 65-69 °C(lit.)
- Boiling point:
- 145-152/5mm
- Density
- 1.376
- Flash point:
- 177℃
- storage temp.
- 2-8°C
- form
- powder to crystal
- color
- White to Yellow to Green
- Water Solubility
- 8.999mg/L(37 ºC)
- CAS DataBase Reference
- 62433-26-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3338
- Product name
- 4'-Chloro-5-fluoro-2-hydroxybenzophenone
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $151
- Updated
- 2024/03/01
- Product number
- C3338
- Product name
- 4'-Chloro-5-fluoro-2-hydroxybenzophenone
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $454
- Updated
- 2024/03/01
- Product number
- C368390
- Product name
- 4''-Chloro-5-fluoro-2-hydroxybenzophenone
- Packaging
- 2.5g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- C368390
- Product name
- 4''-Chloro-5-fluoro-2-hydroxybenzophenone
- Packaging
- 5g
- Price
- $635
- Updated
- 2021/12/16
- Product number
- C368390
- Product name
- 4''-Chloro-5-fluoro-2-hydroxybenzophenone
- Packaging
- 50mg
- Price
- $85
- Updated
- 2021/12/16
4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Chemical Properties,Usage,Production
Uses
4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin.
Preparation
Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%).