ChemicalBook > CAS DataBase List > 2,4,6-Trimethylphenylboronic acid

2,4,6-Trimethylphenylboronic acid

Product Name: 2,4,6-Trimethylphenylboronic acid
CAS No.: 5980-97-2
Chemical Name: 2,4,6-Trimethylphenylboronic acid
Synonyms: MESITYLBORONIC ACID;NSC 157832;AKOS BRN-0050;RARECHEM AH PB 0155;2,4,6-Trimethylpheny;2-MESITYLENEBORONIC ACID;Mesitylene-2-boronic acid;TriMethylphenylboronic aci;2,4,6-TRIMETHYLBORONIC ACID;2,4,6-Trimethylphenylboronicaci
CBNumber: CB7425501
Molecular Formula: C9H13BO2
Formula Weight: 164.01
MOL File: 5980-97-2.mol

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2,4,6-Trimethylphenylboronic acid Property

Melting point:: 115-122 °C (lit.)
Boiling point:: 309.1±52.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
pka: 9.00±0.58(Predicted)
form: powder
color: White to Almost white
BRN: 2831927
InChI: InChI=1S/C9H13BO2/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5,11-12H,1-3H3
InChIKey: BZXQRXJJJUZZAJ-UHFFFAOYSA-N
SMILES: B(C1=C(C)C=C(C)C=C1C)(O)O
CAS DataBase Reference: 5980-97-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38-10
Safety Statements: 37/39-26-33-29-16-3/7/9-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 542318
Product name: 2,4,6-Trimethylphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $106
Updated: 2025/07/31

TCI Chemical

Product number: T1960
Product name: 2,4,6-Trimethylphenylboronic Acid
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: T1960
Product name: 2,4,6-Trimethylphenylboronic Acid
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TRC

Product number: M258758
Product name: Mesitylboronicacid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: M258758
Product name: Mesitylboronicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2,4,6-Trimethylphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

suzuki reaction

Uses

Reactant involved in:

Cross-coupling with α-bromocarbonyl compounds or 2,6-disubstituted bromoarenes
Suzuki-Miyaura coupling for synthesis of biphenyl arsine ligands
Addition reactions to naphthyridine N-oxides or β-aryloxyacrylates

General Description

Contains varying amounts of anhydride.

Synthesis

576-83-0

5980-97-2

The general procedure for the synthesis of 2,4,6-trimethylphenylboronic acid from 2-bromo-1,3,5-trimethylbenzene was as follows: magnesium chips (60.27 mmol) were added to a dry three-necked round-bottomed flask along with anhydrous tetrahydrofuran (30 mL), and the suspension was stirred to form a suspension. Bromoisopropene (13.07 mmol) was slowly added and heated to initiate the formation of Grignard's reagent. Subsequently, 2-bromo-1,3,5-trimethylbenzene (32.02 mmol) was dissolved in anhydrous tetrahydrofuran (30 mL) and slowly added dropwise to the reaction system through a constant pressure dropping funnel. The reaction mixture was heated to reflux for 4.5 hours. Upon completion, the reaction system was cooled to -78 °C. Triethyl borate (111.66 mmol) was added dropwise over 15 minutes. After the dropwise addition was completed, the reaction system was allowed to slowly warm up to room temperature and stirring was continued for 5 hours. Subsequently, the reaction mixture was cooled to 0 °C, the reaction was quenched with 1 M hydrochloric acid solution and stirred for 2 hours. The reaction mixture was extracted three times with ether and the organic phases were combined. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After drying, the desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was recrystallized in benzene to give pure 2,4,6-trimethylphenylboronic acid (26.10 mmol, 58% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) and 13C-NMR (100 MHz, CDCl3) with the following data: 1H-NMR δ= 6.82 (s, 2H), 4.73 (brs, 2H), 2.33 (s, 6H), 2.26 (s, 3H); 13C-NMR δ= 139.64, 138.66, 127.99, 127.26, 22.89, 22.03, 21.12.

References

[1] Organic Letters, 2011, vol. 13, # 17, p. 4479 - 4481
[2] Patent: EP1623971, 2006, A1. Location in patent: Page/Page column 19
[3] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6319 - 6337
[4] Organic Letters, 2014, vol. 16, # 17, p. 4662 - 4665

2,4,6-Trimethylphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4,6-Trimethylphenylboronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Mesitylboronic acid 5980-97-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4,6-Trimethylphenylboronic acid 5980-97-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,4,6-Trimethylphenylboronic acid 5980-97-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

5980-97-2, 2,4,6-Trimethylphenylboronic acidRelated Search:

Hyaluronic acid 5-Methyl-1H-benzotriazole 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzaldehyde Tolyltriazole Folic acid Phenylboronic acid 3,5-Dimethylphenylboronic acid 3-(Trifluoromethyl)benzoic acid Trityl candesartan 4'-(Trifluoromethyl)acetophenone Ethyl 2-(Chlorosulfonyl)acetate 4-Tolylboronic acid Citric acid Ascoric Acid TRIMETHYL PHLOROGLUCINOL 2,4,6-TRIISOPROPYLBENZENEBORONIC ACID 2,4,6-TRIMETHYLBENZENEBORONIC ACID NEOPENTYL GLYCOL CYCLIC ESTER

Mesitylboronic acid~2,4,6-Trimethylphenylboronic acid

MESITYLBORONIC ACID

RARECHEM AH PB 0155

2,4,6-TRIMETHYLBORONIC ACID

2,4,6-Trimethylbenzeneboronic acid, Mesitylene-2-boronic acid

2,4,6-Trimethylphenylboronic acid,95%

2,4,6-Trimethylpheny

Mesitylene-2-boronic acid

2-Mesityleneboronic Acid 2,4,6-Trimethylbenzeneboronic Acid

2,4,6-TRIMETHYLBENZENEBORONIC ACID; MESITYLBORONIC ACID

TriMethylphenylboronic aci

Boronic acid,B-(2,4,6-trimethylphenyl)-

NSC 157832

2,4,6-TRIMETHYLBENZENEBORONIC ACID

2,4,6-TRIMETHYLPHENYLBORONIC ACID

2-MESITYLENEBORONIC ACID

AKOS BRN-0050

2,4,6-Trimethylpenylboronic acid

B-(2,4,6-trimethylphenyl)-Boronicacid

2,4,6-Trimethylphenylboronicaci

2,4,6-Trimethylphenylboronic acid（contains varying amounts of Anhydride）

2,4,6-Trimethylphenylboronic acid - [T5620]

5980-97-2

C6H2CH33BOH2

Organometallic Reagents

B (Classes of Boron Compounds)

Boronic Acids

Boronic Acids and Derivatives

Aryl

Boronic acids

Aryl

Organoborons

B (Classes of Boron Compounds)

Boronic acid