ChemicalBook > CAS DataBase List > TYRPHOSTIN AG 1296

TYRPHOSTIN AG 1296

Product Name
TYRPHOSTIN AG 1296
CAS No.
146535-11-7
Chemical Name
TYRPHOSTIN AG 1296
Synonyms
1296;AG 1296;A 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296 (Tyrphostin AG 1296);Tyrphostin AG1296, 10 mM in DMSO;6,7-DIMETHOXY-3-PHENYLQUINOXALINE
CBNumber
CB7435034
Molecular Formula
C16H14N2O2
Formula Weight
266.29
MOL File
146535-11-7.mol
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TYRPHOSTIN AG 1296 Property

Boiling point:
420.2±40.0 °C(Predicted)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO.
form 
White solid
pka
0.48±0.30(Predicted)
color 
Yellow
Sensitive 
Light Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67039
Product name
Tyrphostin AG-1296
Purity
98%
Packaging
5mg
Price
$182
Updated
2021/12/16
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
25mg
Price
$448
Updated
2024/03/01
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TYRPHOSTIN AG 1296 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.

Uses

Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.

Definition

ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.

target

PDGFR

References

1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

TYRPHOSTIN AG 1296 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN AG 1296 Suppliers

Americas 1 China 72 Europe 1 India 3 Japan 3 Switzerland 2 United Kingdom 3 United States 20 Global 105
Target molecule Corp.
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857-239-0968
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service1@targetmol.com
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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InvivoChem
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708-557-7486
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sales@invivochem.cn
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United States
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Aladdin Scientific
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+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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View Lastest Price from TYRPHOSTIN AG 1296 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN AG 1296 146535-11-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

146535-11-7, TYRPHOSTIN AG 1296Related Search:

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  • TYRPHOSTIN AG 1296
  • AG 1296
  • 6,7-DIMETHOXY-2-PHENYLQUINOXALINE
  • 6,7-DIMETHOXY-3-PHENYLQUINOXALINE
  • Quinoxaline,6,7-dimethoxy-2-phenyl-
  • AG-1296;AG 1296;
  • AG 1296 - CAS 146535-11-7 - Calbiochem
  • AG-1296 (Tyrphostin AG 1296)
  • Tyrphostin AG 1296 (AG 1296)
  • 1296
  • TYRPHOSTIN AG 1296 USP/EP/BP
  • Fms like tyrosine kinase 3,PDGF,Apoptosis,CD117,inhibit,platelet-derived,CD135,SCFR,Tyrphostin AG-1296,c-Kit,PDGFR,FLT3,cell,AG1296,growth,stem,Inhibitor,Tyrphostin AG1296,Cluster of differentiation antigen 135,AG-1296,factor,Platelet-derived growth factor receptor
  • A 1296
  • AG 1296, protein tyrosine kinase inhibitor
  • Tyrphostin AG1296, 10 mM in DMSO
  • 146535-11-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Receptor Tyrosine Kinase Inhibitors
  • Platelet Derived Growth Factor Receptor (PDGFR)
  • Kinase/Phosphatase Biology
  • Inhibitors