ChemicalBook > CAS DataBase List > ACETYLSALICYLIC ANHYDRIDE

ACETYLSALICYLIC ANHYDRIDE

Product Name
ACETYLSALICYLIC ANHYDRIDE
CAS No.
1466-82-6
Chemical Name
ACETYLSALICYLIC ANHYDRIDE
Synonyms
Aspirin IMpurity F;2-(Acetyloxy)benzoic anhydride;Vigal;pircan;contraflu;NSC 63848;NSC 80056;aspirinanhydride;Aspirin Impurity 6;Aspirin EP Impurity F
CBNumber
CB7439577
Molecular Formula
C18H14O7
Formula Weight
342.3
MOL File
1466-82-6.mol
More
Less

ACETYLSALICYLIC ANHYDRIDE Property

Melting point:
80-83 °C
Boiling point:
511.2±35.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
White to Off-White
BRN 
2015320
InChI
InChI=1S/C18H14O7/c1-11(19)23-15-9-5-3-7-13(15)17(21)25-18(22)14-8-4-6-10-16(14)24-12(2)20/h3-10H,1-2H3
InChIKey
OAWXYINGQXLWOE-UHFFFAOYSA-N
SMILES
C(=O)(OC(=O)C1C=CC=CC=1OC(C)=O)C1C=CC=CC=1OC(C)=O
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
VO0710000
F 
10-21
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1942
Product name
Acetylsalicylic Anhydride (Aspirin Impurity F)
Purity
PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging
50mg
Price
$697.3
Updated
2025/07/31
TRC
Product number
A187785
Product name
AcetylsalicylicAnhydride
Packaging
10mg
Price
$85
Updated
2021/12/16
TRC
Product number
A187785
Product name
AcetylsalicylicAnhydride
Packaging
25mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
7270AA
Product name
2-Acetoxybenzoicanhydride
Packaging
100mg
Price
$91
Updated
2021/12/16
AK Scientific
Product number
7270AA
Product name
2-Acetoxybenzoicanhydride
Packaging
250mg
Price
$107
Updated
2021/12/16
More
Less

ACETYLSALICYLIC ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Acetylsalicylic Acid Impurity D

Uses

Acetylsalicylic Acid (A187780) Impurity D.

Synthesis

50-78-2

1466-82-6

General procedure for the synthesis of 2-(acetyloxy)benzoic anhydride from acetylsalicylic acid: 1. prepare a suspension of 2-acetoxybenzoic acid (5.0 g, 28 mmol) in 30 mL of dichloromethane. 2. a solution of N,N'-dicyclohexylcarbodiimide (DCC, 2.9 g, 13.9 mmol) in 10 mL of dichloromethane was added to the above suspension. 3. The reaction mixture was stirred at room temperature overnight. 4. After completion of the reaction, the by-product dicyclohexylurea (DCU) was filtered through a glass filter and washed with a small amount of dichloromethane. 5. The solvent was evaporated and the resulting residue was dissolved in ethyl acetate. 6. The resulting suspension was filtered through a glass filter to remove residual DCU. 7. The filtrate was evaporated to give 2-(acetyloxy)benzoic anhydride as a clear thick oil, which solidified after storage at -20 °C. Yield: 4.6 g (quantitative). 1H NMR (CDCl3, 400 MHz): δ 8.08 (d, 2H, J = 7.9 Hz), 7.70 (t, 2H, J = 7.8 Hz), 7.40 (t, 2H, J = 7.7 Hz), 7.19 (d, 2H, J = 8.1 Hz), 2.31 (s, 6H). 13C NMR (CDCl3, 100 MHz): δ 169.42, 159.29, 151.83, 135.54, 132.24, 126.29, 124.42, 121.69, 20.89. IR (KBr) νmax (cm-1): 3570 (w), 3491 (w), 3445 (w), 3332 (br), 3205 (w), 3100 (s, CH), 2932 (s, CH), 2855 (w), 2409 (w), 2032 (w), 1789 (br, C=O), 1728 (br, C=O) , 1603 (s, C=C), 1581 (s), 1484 (s), 1451 (s), 1369 (s), 916 (s), 506 (s). HRMS m/z Calcd. for C18H14Na7O6: (M + Na)+ 365.0637. Found: 365.0638. Melting point: 80-85°C.

References

[1] Patent: WO2015/89389, 2015, A1. Location in patent: Paragraph 0098
[2] Tetrahedron Letters, 2016, vol. 57, # 3, p. 325 - 328
[3] Synthetic Communications, 2001, vol. 31, # 3, p. 395 - 399
[4] Chemische Berichte, 1910, vol. 43, p. 2990
[5] Chem. Zentralbl., 1911, vol. 82, # I, p. 1568

ACETYLSALICYLIC ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ACETYLSALICYLIC ANHYDRIDE Suppliers

Canada 2 China 106 Germany 1 India 13 Norway 1 Switzerland 1 United Kingdom 4 United States 15 Global 143
Shanghai Sainty Biotechnology Co., Ltd.
Tel
021-58957915 17721108391
Fax
QQ: 907522080
Email
907522080@qq.com
Country
China
ProdList
996
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3731
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-68652053 15863796298;
Email
2310993908@qq.com
Country
China
ProdList
2437
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hangzhou ChangCun Biotechnology Co., Ltd.
Tel
0571-; 13567100326
Fax
QQ158848739
Email
158848739@qq.com
Country
China
ProdList
108
Advantage
50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-0755-28967200-8062 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9624
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
13316949107 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9564
Advantage
58
ROSEWA HOLDING GROUP CO.,LIMITED
Tel
+86-023-62871537
Email
sales@rosewachem.com
Country
China
ProdList
2803
Advantage
58
Xinyi Kaiwu Chemical Technology Co., Ltd.
Tel
0516-0516-88997009 18651776937
Email
4164357@qq.com
Country
China
ProdList
3204
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15109
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 13298656710
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
7448
Advantage
58
Nanjing Boomking Industry Co., Ltd
Tel
15298391928
Email
cherry_kingstone@163.com
Country
China
ProdList
823
Advantage
58
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3609
Advantage
58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13965
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81148696 +86-17392712697
Email
1022@dideu.com
Country
China
ProdList
3995
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038 18502138905
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-029-81024372 17792795018
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10003
Advantage
58
Wuhan kemike Biomedical Technology Co., Ltd
Tel
027-87747081 18186681184
Email
1344475572@qq.com
Country
China
ProdList
7220
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Shandong WorldSun Biological Technology Co., Ltd.
Tel
0531-88723173 18596073690
Email
1047208234@qq.com
Country
China
ProdList
6776
Advantage
58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD
Tel
0755-0755-83725350 13380397412
Fax
0755-28094224
Email
3001280422@qq.com
Country
China
ProdList
10001
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
More
Less

View Lastest Price from ACETYLSALICYLIC ANHYDRIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
ACETYLSALICYLIC ANHYDRIDE 1466-82-6
Price
US $4656.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-25

1466-82-6, ACETYLSALICYLIC ANHYDRIDERelated Search:

Acetylsalicylic acid Sasapyrine 4-Hydroxybenzoic acid ACETYLSALICYLSALICYLIC ACID 3-Hydroxybenzoic acid 4-amino-6-hydroxybenzene-1,3-dicarboxylic acid 2-Ethoxybenzoic acid Methyl salicylate 2-ETHOXYBENZYL ALCOHOL Benzyl benzoate Methyl 2-methoxybenzoate Ethyl 2-ethoxybenzoate 2-Methoxybenzoic acid ethyl ester Benzyl salicylate ACETYLSALICYLIC ACID METHYL ESTER ACETYLSALICYLIC ANHYDRIDE Ethyl 2-hydroxybenzoate 2-Ethoxybenzaldehyde

  • O-ACETYLSALICYLIC ANHYDRIDE
  • 2-(acetyloxy)-benzoicacianhydride
  • 2-(acetyloxy)benzoicacidanhydride
  • acetylsalicylicacidanhydride
  • aspirinanhydride
  • contraflu
  • pircan
  • salicylicacid,acetate,anhydride
  • 2-acetoxybenzoic anhydride
  • ACETYLSALICYLIC ANHYDRIDE
  • ACETYLSALISYLIC ACID IMP F
  • ACETYLSALICYLIC ACID IMPURITY F
  • 2-(Acetyloxy)benzoic Acid 1,1'-Anhydride
  • NSC 63848
  • NSC 80056
  • Vigal
  • Bis(2-acetoxybenzoic acid)anhydride
  • Bis(2-acetyloxybenzoic)anhydride
  • (2-acetyloxybenzoyl) 2-acetyloxybenzoate
  • (2-acetyloxyphenyl)carbonyl 2-acetyloxybenzoate
  • 2-acetoxybenzoic acid (2-acetoxybenzoyl) ester
  • Benzoic acid, 2-(acetyloxy)-, 1,1'-anhydride
  • Aspirin IMpurity F
  • (Acetysalicyclclic anhydride)
  • Acetylsalicylic Acid IMpurity F (Aspirin IMpurity F)
  • Aspirin EP Impurity F
  • Acetylsalicylic Anhydride (Aspirin Impurity F)
  • Aspirin Impurity 6
  • Acetylsalicylic Anhydride (Aspirin Impurity F) solution
  • 2-acetyloxybenzoic acid [(2-acetyloxyphenyl)-oxomethyl] ester
  • Acetylsalicylic Acid Impurity 6（Acetylsalicylic Acid EP Impurity F）
  • Acetylsalicylic Acid EP Impurity F
  • 2-(Acetyloxy)benzoic Anhydride (Ace
  • Acetylsalicylic Acid EP Impurity F (Aspirin Impurity F)
  • Carbasalate EP Impurity A
  • 2-(Acetyloxy)benzoic anhydride
  • Acetylsalicylic Acid EP Impurity F (Acetylsalicylic Anhydride)
  • Aspirin Impurity FQ: What is Aspirin Impurity F Q: What is the CAS Number of Aspirin Impurity F Q: What is the storage condition of Aspirin Impurity F Q: What are the applications of Aspirin Impurity F
  • Aspirin (Acetylsalicylic Acid) EP Impurity F
  • Carbasalate Calcium EP Impurity A
  • Acetylsalicylic Acid EP Impurity F (Carbasalate Calcium EP Impurity A)
  • 2-(Acetyloxy)benzoic Anhydride (Acetylsalicylic Anhydride)
  • 1466-82-6
  • C18H14O7
  • Building Blocks
  • Carboxylic Acid Anhydrides
  • Carbonyl Compounds
  • Organic Building Blocks
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals