ChemicalBook > CAS DataBase List > 5-Hydroxynicotinic acid

5-Hydroxynicotinic acid

Product Name
5-Hydroxynicotinic acid
CAS No.
27828-71-3
Chemical Name
5-Hydroxynicotinic acid
Synonyms
AKOS NCG-0022;5-Hydroxynicotinic;Nicotinic acid-004;TIMTEC-BB SBB010273;5-Hydroxynicotinic a;5-hydroxy-nicotinicaci;5-Hydroxy nicotic acid;5-HYDROXYNICOTINIC ACID;Hydroxynicotinicacid 5-;5-HydroxynicotinicAcid>
CBNumber
CB7447677
Molecular Formula
C6H5NO3
Formula Weight
139.11
MOL File
27828-71-3.mol
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5-Hydroxynicotinic acid Property

Melting point:
299 °C
Boiling point:
519.3±35.0 °C(Predicted)
Density 
1.485±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
2.08±0.10(Predicted)
form 
powder to crystal
color 
White to Yellow
BRN 
115847
InChI
InChI=1S/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10)
InChIKey
ATTDCVLRGFEHEO-UHFFFAOYSA-N
SMILES
C1=NC=C(O)C=C1C(O)=O
CAS DataBase Reference
27828-71-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
QT1757500
Hazard Note 
Harmful/Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
672742
Product name
5-Hydroxynicotinic acid
Purity
97%
Packaging
1g
Price
$114
Updated
2021/12/16
Sigma-Aldrich
Product number
672742
Product name
5-Hydroxynicotinic acid
Purity
97%
Packaging
5g
Price
$452
Updated
2021/12/16
TCI Chemical
Product number
H1226
Product name
5-Hydroxynicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$90
Updated
2024/03/01
Alfa Aesar
Product number
H30725
Product name
5-Hydroxynicotinic acid, 97%
Packaging
5g
Price
$131
Updated
2021/12/16
Alfa Aesar
Product number
H30725
Product name
5-Hydroxynicotinic acid, 97%
Packaging
1g
Price
$41
Updated
2021/12/16
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5-Hydroxynicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white to yellow solid

Uses

5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).

Definition

ChEBI: 5-Hydroxynicotinic acid is an aromatic carboxylic acid and a member of pyridines.

Research

5-hydroxynicotinic acid (5HNA) could be used as a model the following questions were addressed: (i) is it possible to promote the crystallization of a tautomeric form dominant in a specific solvent through solvate formation? (ii) Does that form persist if the memory of solvation is erased through thermal desolvation?
A thermodynamic analysis based on DSC and Calvet drop microcalorimetry results allowed us to rationalize these observations, indicating that (i) 5HNA·H2O is predicted to spontaneously lose water, even for a relative humidity of 100%, hence its robustness is most certainly of kinetical origin; (ii) 5HNA·DMSO is thermodynamically stable when a saturation DMSO pressure can be established over the sample, but becomes unstable when exposed to an atmosphere where the solvent is absent. The kinetically easier desolvation of 5HNA·DMSO compared to 5HNA·H2O may be related to the fact that water is isolated in the crystal lattice (isolated site hydrate) while DMSO is placed in channels (channel solvate)[1].

References

[1] Joseph, Abhinav et al. “Tautomer selection through solvate formation: the case of 5-hydroxynicotinic acid?.” CrystEngComm 13 (2019): 2220–2233.

5-Hydroxynicotinic acid Preparation Products And Raw materials

Raw materials

5-Aminonicotinic acid Ethanol Sodium nitrite Ethyl acetate Dichloromethane Sodium hydroxide Thionyl chloride Sulfuric acid

Preparation Products

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View Lastest Price from 5-Hydroxynicotinic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
5-Hydroxynicotinic acid 27828-71-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Hydroxynicotinic acid 27828-71-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-07
Shijiazhuang Dowell Chemical Co.,Ltd
Product
5-Hydroxynicotinic acid 27828-71-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2MT/Month
Release date
2024-12-03

27828-71-3, 5-Hydroxynicotinic acid Related Search:

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