AURINTRICARBOXYLIC ACID

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AURINTRICARBOXYLIC ACID

Product Name: AURINTRICARBOXYLIC ACID
CAS No.: 4431-00-9
Chemical Name: AURINTRICARBOXYLIC ACID
Synonyms: ATA;SKL331;e)-6-oxo-;aluminonfreeacid;TIMTEC-BB SBB005410;AURINTRICARBONIC ACID;aurintricarboxylicaci;LABOTEST-BB LT00080677;AURINTRICARBOXYLIC ACID;aurinetricarboxylic acid
CBNumber: CB7463004
Molecular Formula: C22H14O9
Formula Weight: 422.34
MOL File: 4431-00-9.mol

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AURINTRICARBOXYLIC ACID Property

Melting point:: 300 °C(lit.)
Boiling point:: 458.99°C (rough estimate)
Density: 1.3860 (rough estimate)
refractive index: 1.6230 (estimate)
storage temp.: +15C to +30C
solubility: 1 M NH₄OH: 10 mg/mL
form: powder
pka: 2.20±0.20(Predicted)
color: dark red to brown
Water Solubility: Insoluble in water.
BRN: 2228904
CAS DataBase Reference: 4431-00-9(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy- (4431-00-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: GU4790000
TSCA: Yes

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1895
Product name: Aurintricarboxylic acid
Purity: practical grade, ≥85% (titration), powder
Packaging: 5g
Price: $69.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 189400
Product name: Aurintricarboxylic Acid
Packaging: 100mg
Price: $56.2
Updated: 2024/03/01

Alfa Aesar

Product number: A15905
Product name: Aurintricarboxylic acid
Packaging: 5g
Price: $47
Updated: 2024/03/01

Alfa Aesar

Product number: A15905
Product name: Aurintricarboxylic acid
Packaging: 25g
Price: $128.65
Updated: 2024/03/01

Sigma-Aldrich

Product number: A1895
Product name: Aurintricarboxylic acid
Purity: practical grade, ≥85% (titration), powder
Packaging: 25g
Price: $240
Updated: 2024/03/01

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AURINTRICARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

deep red coarse crystalline powder

Uses

endonuclease inhibitor; apoptosis inhibitor, topoisomerase II inhibitor

Uses

Aurintricarboxylic acid is employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It Inhibits protein-nucleic acid interactions. It stimulates the tyrosine phosphorylation of MAP kinases.

Definition

ChEBI: A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.

Biological Activity

Readily polymerizes in aqueous solution, forming a stable free radical th at inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease th at is activated during apoptosis.

Purification Methods

The acid is dissolved in aqueous NaOH, NaHSO3 solution is added until the colour is discharged and then the tricarboxylic acid is precipitated with HCl. [Heisig & Lauer Org Synth Coll Vol I 54 1941, Beilstein 10 IV 4161]. Do not extract the acid with hot water because it softens, forming a viscous mass. Make a solution in aqueous NH3. Aluminon is the NH4 salt.

AURINTRICARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

4-Nitrobenzoyl chloride Methylenedisalicylic acid

Preparation Products

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AURINTRICARBOXYLIC ACID Suppliers

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View Lastest Price from AURINTRICARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: AURINTRICARBOXYLIC ACID 4431-00-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

Career Henan Chemical Co

Product: AURINTRICARBOXYLIC ACID 4431-00-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

4431-00-9, AURINTRICARBOXYLIC ACIDRelated Search:

Sorbic acid Aluminon 3-VINYLBENZALDEHYDE 5-PHENYLPENTA-2,4-DIENOIC ACID 5-Methylsalicylaldehyde TRANS-2-PENTENOIC ACID TRANS-2-PENTEN-1-OL 5-Methylsalicylic acid 5,5'-Methylenedisalicylic acid 2,4-DIMETHYL-1,3-PENTADIENE 1-METHYL-1,4-CYCLOHEXADIENE (E,E)-2,4-Hexadienal TRANS,TRANS-2,4-HEXADIEN-1-OL trans-2-Methyl-2-pentenoic acid m,alpha-dimethylstyrene AURINTRICARBOXYLIC ACID ROSOLIC ACID Allylacetic acid

Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

1,4-cyclohexadiene-1-carboxylicacid,3-(bis(3-carboxy-4-hydroxyphenyl)methylen

5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-benzoicaci

aluminonfreeacid

e)-6-oxo-

5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)

bis(2-hydroxybenzoic acid)

TIMTEC-BB SBB005410

LABOTEST-BB LT00080677

AURINTRICARBOXYLIC ACID

ATA

5,5-(3-carboxy-4-oxocyclohexa-2,5-dienylidenemethylene)di(salicylic acid)

aurinetricarboxylic acid

AURINTRICARBOXYLIC ACID FREE ACIDPRACTIC AL GRADE

Aurintricarboxylic Acid (Ata)

AURINTRICARBONIC ACID

Aurintricarboxylic acid, tech., 85%

1-Oxo-4-[bis(3-carboxy-4-hydroxyphenyl)methylene]-2,5-cyclohexadiene-2-carboxylic acid

5,5'-[(3-Carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis(2-hydroxybenzoic acid)

Aurintricarboxylic acid,85%,tech.

5,5'-((3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)Methylene)bis(2-hydroxybenzoic acid)

Benzoic acid, 3,3'-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxy-

aurintricarboxylicaci

Aurintricarboxylic Acids (Technical Grade)

SKL331

5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid

ATA(Aurintricarboxylic acid)

Aurintricarboxylic acid (ATA), Apoptosis inhibitor

Aurintricarboxylic acid, 10 mM in DMSO

4431-00-9

C22H14O9

DNA metabolism

DNA Repair Regulators

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Apoptosis and Cell Cycle

Colours, Dyes, Indicators & Pigments