ChemicalBook > CAS DataBase List > AZD-0284

AZD-0284

Product Name
AZD-0284
CAS No.
2101291-07-8
Chemical Name
AZD-0284
Synonyms
AZD-0284;AZD-0284, 10 mM in DMSO;(R)-2-Acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide; (1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide;1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, (1R)-;tract,RAR-related orphan receptor,IL-17F,L-23R,Inhibitor,AZD-0284,plaque,respiratory,vulgaris,production,IL-17A,TH17,psoriasis,IL-22,AZD 0284,inhibit,cells,ROR,AZD0284
CBNumber
CB74667590
Molecular Formula
C21H18F6N2O5S
Formula Weight
524.43
MOL File
2101291-07-8.mol
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AZD-0284 Property

Boiling point:
731.9±60.0 °C(Predicted)
Density 
1.534±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (190.68 mM)
form 
Solid
pka
9.26±0.15(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0077736
Product name
AZD-0284
Purity
99.92%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0077736
Product name
AZD-0284
Purity
99.92%
Packaging
10mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0077736
Product name
AZD-0284
Purity
99.92%
Packaging
50mg
Price
$2250
Updated
2021/12/16
ChemScene
Product number
CS-0077736
Product name
AZD-0284
Purity
99.92%
Packaging
100mg
Price
$3350
Updated
2021/12/16
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AZD-0284 Chemical Properties,Usage,Production

Uses

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment[1].

References

[1] Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 Drug Design and Delivery Symposium 26 October 2017
[2] Asimus S, et al. Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284 [published online ahead of print, 2020 Feb 17]. Br J Clin Pharmacol. 2020;10.1111/bcp.14253. DOI:10.1111/bcp.14253

AZD-0284 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-0284 Suppliers

China 43 United States 4 Global 47
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58

2101291-07-8, AZD-0284Related Search:

AZD-5672 AZD0364 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

  • AZD-0284
  • 1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, (1R)-
  • (1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide
  • tract,RAR-related orphan receptor,IL-17F,L-23R,Inhibitor,AZD-0284,plaque,respiratory,vulgaris,production,IL-17A,TH17,psoriasis,IL-22,AZD 0284,inhibit,cells,ROR,AZD0284
  • (R)-2-Acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide
  • AZD-0284, 10 mM in DMSO
  • 2101291-07-8
  • C21H18F6N2O5S