VU 0463271

Product Name: VU 0463271
CAS No.: 1391737-01-1
Chemical Name: VU 0463271
Synonyms: VU 0463271;VU0463271, 10 mM in DMSO;Inhibitor,KcsA,VU0463271,Potassium Channel,VU 0463271,VU-0463271,inhibit;N-Cyclopropyl-N-(4-methylthiazol-2-yl)-2-((6-phenylpyridazin-3-yl)thio)acetamide;N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide;Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-;VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide);VU0463271 (Synonyms: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide)
CBNumber: CB74668658
Molecular Formula: C19H18N4OS2
Formula Weight: 382.5
MOL File: 1391737-01-1.mol

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VU 0463271 Property

storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
color: off-white to blue-gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2333
Product name: VU0463271
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $89
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2333
Product name: VU0463271
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $359
Updated: 2025/07/31

Tocris

Product number: 4719
Product name: VU0463271
Purity: ≥98%(HPLC)
Packaging: 10
Price: $196
Updated: 2021/12/16

Tocris

Product number: 4719
Product name: VU0463271
Purity: ≥98%(HPLC)
Packaging: 50
Price: $825
Updated: 2021/12/16

Usbiological

Product number: 257069
Product name: VU 0463271
Packaging: 10mg
Price: $432
Updated: 2021/12/16

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VU 0463271 Chemical Properties,Usage,Production

Uses

VU 0463271 is a novel antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2).

Biological Activity

VU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor th at displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61, 537, and 568 nM, respectively). VU0463271 exhibits much reduced efficacy against the related Na-K-2Cl cotransporter 1 (NKCC1 inhibition max ~37% at 100 μM) and little affinity toward a panel of 68 GPCRs, ion channels, and transporters. Although VU0463271 is reported to exhibit affinity toward mitochondrial translocator protein TSPO (IC50 of 204 nM against PK11195 binding; r at heart) and inhibitory potency against α1B adrenergic receptor (IC50 of 364.7 nM; human α1B CHO transfectants), these proteins are not known to affect chloride homeostasis.

in vivo

VU0463271 is found to be a moderate-to-high clearance compound in rat (CL=57 mL/min/kg) following intravenous administration (1 mg/kg); the low volume of distribution at steady state (Vss 0.4 L/kg), coupled with moderate-to-high clearance produce a relatively short t1/2 (9 min) in vivo^[1].

storage

Store at +4°C

VU 0463271 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0463271 Suppliers

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1391737-01-1, VU 0463271Related Search:

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VU 0463271

VU0463271 (Synonyms: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide)

N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide)

Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-

Inhibitor,KcsA,VU0463271,Potassium Channel,VU 0463271,VU-0463271,inhibit

VU0463271, 10 mM in DMSO

N-Cyclopropyl-N-(4-methylthiazol-2-yl)-2-((6-phenylpyridazin-3-yl)thio)acetamide

1391737-01-1