3-Amino-6-bromopyrazine-2-carboxylic acid
- Product Name
- 3-Amino-6-bromopyrazine-2-carboxylic acid
- CAS No.
- 486424-37-7
- Chemical Name
- 3-Amino-6-bromopyrazine-2-carboxylic acid
- Synonyms
- 3-AMINO-6-BROMOPYRAZINE-2-CARB;3-Amino-6-bromopyrazine-2-carboxylicaci;3-AMino-6-broMo-2-pyrazinecarboxylic Acid;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID;2-Pyrazinecarboxylic acid, 3-amino-6-bromo-;3-Amino-6-bromopyrazine-2-carboxylicacid,98%;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID, 95+%;3- amino -6- bromopyrazoline -2- carboxylic acid;3-Amino-6-bromopyrazine-2-carboxylic acid ISO 9001：2015 REACH;2-Amino-5-bromo-3-carboxypyrazine, 2-Amino-5-bromo-3-carboxy-1,4-diazine
- CBNumber
- CB7475465
- Molecular Formula
- C5H4BrN3O2
- Formula Weight
- 218.01
- MOL File
- 486424-37-7.mol
3-Amino-6-bromopyrazine-2-carboxylic acid Property
- Melting point:
- 178-183℃
- Boiling point:
- 397.8±42.0 °C(Predicted)
- Density
- 2.039±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in dimethyl sulfoxide and methanol.
- pka
- 3.26±0.10(Predicted)
- form
- Solid
- color
- Pale yellow
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H4BrN3O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H2,7,8)(H,10,11)
- InChIKey
- MTNAQEKMSVDTAQ-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(Br)=CN=C1N
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A601860
- Product name
- 2-Amino-5-bromopyrazine-3-carboxylicAcid
- Packaging
- 2g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A601860
- Product name
- 2-Amino-5-bromopyrazine-3-carboxylicAcid
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A601860
- Product name
- 2-Amino-5-bromopyrazine-3-carboxylicAcid
- Packaging
- 10g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- OR40653
- Product name
- 3-Amino-6-bromopyrazine-2-carboxylicacid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H57-9-01
- Product name
- 3-Amino-6-bromopyrazine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
3-Amino-6-bromopyrazine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
3-Amino-6-bromopyrazine-2-carboxylic acid used to prepare 3-bromo-5-phenylpyrazine-2-amine. It serves as an intermediate in organic synthesis and pharmaceuticals.
Synthesis
6966-01-4
486424-37-7
Step 2: Methyl 3-amino-6-bromopyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) were dissolved in a mixed solvent of methanol (20 mL) and water (20 mL), heated to 90 °C, and the reaction was carried out for 2 hours. After completion of the reaction, the reaction mixture was cooled, neutralized with hydrochloric acid to pH neutral, and the precipitated solid was collected by filtration. The resulting 3-amino-6-bromopyrazine-2-carboxylic acid was used directly in the next step of the reaction without further purification (4.80 g, 99% yield).
References
[1] Patent: WO2011/143419, 2011, A1. Location in patent: Page/Page column 44-45
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2784 - 2788
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[4] Patent: WO2017/123588, 2017, A1. Location in patent: Paragraph 0031; 0032; 0033
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90
3-Amino-6-bromopyrazine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-6-bromopyrazine-2-carboxylic acid Suppliers
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View Lastest Price from 3-Amino-6-bromopyrazine-2-carboxylic acid manufacturers
- Product
- 3-Amino-6-bromopyrazine-2-carboxylic acid 486424-37-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29