ChemicalBook > CAS DataBase List > 3-Amino-6-bromopyrazine-2-carboxylic acid

3-Amino-6-bromopyrazine-2-carboxylic acid

Product Name
3-Amino-6-bromopyrazine-2-carboxylic acid
CAS No.
486424-37-7
Chemical Name
3-Amino-6-bromopyrazine-2-carboxylic acid
Synonyms
3-AMINO-6-BROMOPYRAZINE-2-CARB;3-Amino-6-bromopyrazine-2-carboxylicaci;3-AMino-6-broMo-2-pyrazinecarboxylic Acid;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID;2-Pyrazinecarboxylic acid, 3-amino-6-bromo-;3-Amino-6-bromopyrazine-2-carboxylicacid,98%;3-AMINO-6-BROMOPYRAZINE-2-CARBOXYLIC ACID, 95+%;3- amino -6- bromopyrazoline -2- carboxylic acid;3-Amino-6-bromopyrazine-2-carboxylic acid ISO 9001：2015 REACH;2-Amino-5-bromo-3-carboxypyrazine, 2-Amino-5-bromo-3-carboxy-1,4-diazine
CBNumber
CB7475465
Molecular Formula
C5H4BrN3O2
Formula Weight
218.01
MOL File
486424-37-7.mol
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3-Amino-6-bromopyrazine-2-carboxylic acid Property

Melting point:
178-183℃
Boiling point:
397.8±42.0 °C(Predicted)
Density 
2.039±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in dimethyl sulfoxide and methanol.
pka
3.26±0.10(Predicted)
form 
Solid
color 
Pale yellow
Sensitive 
Light Sensitive
InChI
InChI=1S/C5H4BrN3O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H2,7,8)(H,10,11)
InChIKey
MTNAQEKMSVDTAQ-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC(Br)=CN=C1N
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A601860
Product name
2-Amino-5-bromopyrazine-3-carboxylicAcid
Packaging
2g
Price
$65
Updated
2021/12/16
TRC
Product number
A601860
Product name
2-Amino-5-bromopyrazine-3-carboxylicAcid
Packaging
5g
Price
$90
Updated
2021/12/16
TRC
Product number
A601860
Product name
2-Amino-5-bromopyrazine-3-carboxylicAcid
Packaging
10g
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA09806
Product name
2-Amino-5-bromopyrazine-3-carboxylic acid
Packaging
2g
Price
$40
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA09806
Product name
2-Amino-5-bromopyrazine-3-carboxylic acid
Packaging
10g
Price
$140
Updated
2021/12/16
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3-Amino-6-bromopyrazine-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

3-Amino-6-bromopyrazine-2-carboxylic acid used to prepare 3-bromo-5-phenylpyrazine-2-amine. It serves as an intermediate in organic synthesis and pharmaceuticals.

Synthesis

6966-01-4

486424-37-7

Step 2: Methyl 3-amino-6-bromopyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) were dissolved in a mixed solvent of methanol (20 mL) and water (20 mL), heated to 90 °C, and the reaction was carried out for 2 hours. After completion of the reaction, the reaction mixture was cooled, neutralized with hydrochloric acid to pH neutral, and the precipitated solid was collected by filtration. The resulting 3-amino-6-bromopyrazine-2-carboxylic acid was used directly in the next step of the reaction without further purification (4.80 g, 99% yield).

References

[1] Patent: WO2011/143419, 2011, A1. Location in patent: Page/Page column 44-45
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2784 - 2788
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[4] Patent: WO2017/123588, 2017, A1. Location in patent: Paragraph 0031; 0032; 0033
[5] Patent: WO2010/54398, 2010, A1. Location in patent: Page/Page column 90

3-Amino-6-bromopyrazine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-6-bromopyrazine-2-carboxylic acid Suppliers

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View Lastest Price from 3-Amino-6-bromopyrazine-2-carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Amino-6-bromopyrazine-2-carboxylic acid 486424-37-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-29

486424-37-7, 3-Amino-6-bromopyrazine-2-carboxylic acidRelated Search:

Methyl anthranilate Urethane Glycine 4-Dimethylaminobenzoic acid 6-Aminocaproic acid POLYURETHANE 4-Aminobenzoic acid 2-AMINO-5-BROMO-3-METHYLPYRAZINE 2-Amino-5-bromopyrazine 2-BROMO-6-METHYLPYRAZINE 3-Amino-6-bromopyrazine-2-carboxylic acid methyl ester Anthranilic acid 2-AMINO-3-BROMOPYRAZINE-5-CARBOXYLIC ACID 2-AMINO-5-BROMOPYRAZINE-3-CARBOXYLIC ACID, METHYL ESTER 5-amino-6-bromopyrazine-2-carboxylic acid 3-Amino-6-bromopyrazine-2-carboxylic acid CARBOXYLIC ACID 2-AMINO-5-BROMOPYRAZINE-3-CARBOXYLIC ACID

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