ChemicalBook > CAS DataBase List > ML-109

ML-109

Product Name
ML-109
CAS No.
1186649-91-1
Chemical Name
ML-109
Synonyms
ML-109;ML-109, 10 mM in DMSO;ML-109 (CID-25246343);N-(4-((5-(3-Benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyl)oxy)phenyl)acetamide;TSH Receptor,Thyrotropin receptor,inhibit,ML-109,ML 109,Inhibitor,Thyroid-stimulating hormone Receptor,ML109;N-(4-{[5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxyphenyl]methoxy}phenyl)acetamide;N-[4-[[2-Methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]acetamide;Acetamide, N-[4-[[2-methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]-
CBNumber
CB74796672
Molecular Formula
C31H29N3O5
Formula Weight
523.58
MOL File
1186649-91-1.mol
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ML-109 Property

Boiling point:
810.1±65.0 °C(Predicted)
Density 
1.300±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:83.0(Max Conc. mg/mL);158.5(Max Conc. mM)
form 
Solid
pka
8.66±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0069880
Product name
ML-109
Purity
99.12%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0069880
Product name
ML-109
Purity
99.12%
Packaging
10mg
Price
$550
Updated
2021/12/16
Biorbyt Ltd
Product number
orb572982
Product name
ML-109
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
ChemScene
Product number
CS-0069880
Product name
ML-109
Purity
99.12%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0069880
Product name
ML-109
Purity
99.12%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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ML-109 Chemical Properties,Usage,Production

Uses

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

Definition

ChEBI: N-[4-[[5-[5-hydroxy-4-oxo-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide is a member of quinazolines.

References

[1] Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6. DOI:10.1073/pnas.0904506106

ML-109 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML-109 Suppliers

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1186649-91-1, ML-109Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

  • ML-109
  • Acetamide, N-[4-[[2-methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]-
  • N-[4-[[2-Methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]acetamide
  • ML-109 (CID-25246343)
  • TSH Receptor,Thyrotropin receptor,inhibit,ML-109,ML 109,Inhibitor,Thyroid-stimulating hormone Receptor,ML109
  • N-(4-((5-(3-Benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyl)oxy)phenyl)acetamide
  • N-(4-{[5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxyphenyl]methoxy}phenyl)acetamide
  • ML-109, 10 mM in DMSO
  • 1186649-91-1
  • API