GO 6983
- Product Name
- GO 6983
- CAS No.
- 133053-19-7
- Chemical Name
- GO 6983
- Synonyms
- CS-674;gǒ 6983;Gδ 6983;GOE 6983;Go6983(96 %);GO6983 GO-6983;GO 6983 USP/EP/BP;Go 6983, 10 mM in DMSO;Gouml 6983, PKC inhibitor;G 6983 - GO 6983 | Goe 6983
- CBNumber
- CB7498134
- Molecular Formula
- C26H26N4O3
- Formula Weight
- 442.51
- MOL File
- 133053-19-7.mol
GO 6983 Property
- Boiling point:
- 709.0±60.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 20 mg/mL, clear, red
- form
- powder
- pka
- 8.02±0.60(Predicted)
- color
- red
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- G1918
- Product name
- Gö 6983
- Purity
- ≥97%
- Packaging
- 500μg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- G1918
- Product name
- G 6983
- Purity
- ≥97%
- Packaging
- 1mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 365251
- Product name
- Gö 6983 - CAS 133053-19-7 - Calbiochem
- Purity
- A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.
- Packaging
- 500μg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- J67008
- Product name
- G? 6983, 98%
- Packaging
- 1mg
- Price
- $94.5
- Updated
- 2023/06/20
- Product number
- J67008
- Product name
- G? 6983, 98%
- Packaging
- 5mg
- Price
- $259
- Updated
- 2021/12/16
GO 6983 Chemical Properties,Usage,Production
Description
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4
Uses
Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor
Uses
GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).
Definition
ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Biochem/physiol Actions
Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
storage
-20°C
References
1) Gschwendt et al. (1996), Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes; FEBS Lett., 392 77 2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16 3) Rajendran et al. (2013), Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351 4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255
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View Lastest Price from GO 6983 manufacturers
- Product
- GO 6983 133053-19-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12