ChemicalBook > CAS DataBase List > 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

Product Name
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
CAS No.
545380-34-5
Chemical Name
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
Synonyms
QNZ;CS-902;EVP4593;EVP-4593;EVP 4593;CAY10470;QNZ (EVP4593);CAY10470|||EVP4593;QNZ, 10 mM in DMSO;QNZ, NF-kB inhibitor
CBNumber
CB7500822
Molecular Formula
C22H20N4O
Formula Weight
356.42
MOL File
545380-34-5.mol
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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Property

Melting point:
169-175°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0579
Product name
EVP4593
Purity
≥98% (HPLC)
Packaging
5mg
Price
$164
Updated
2025/07/31
Sigma-Aldrich
Product number
481407
Product name
NF-κB Activation Inhibitor
Purity
InSolution, ≥98%
Packaging
1mg
Price
$155
Updated
2025/07/31
Sigma-Aldrich
Product number
481406
Product name
NF-κB Activation Inhibitor
Packaging
1mg
Price
$155
Updated
2025/07/31
TCI Chemical
Product number
Q0109
Product name
QNZ
Packaging
5MG
Price
$92
Updated
2025/07/31
TCI Chemical
Product number
Q0109
Product name
QNZ
Packaging
25MG
Price
$276
Updated
2025/07/31
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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Chemical Properties,Usage,Production

Description

QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50?= 11 nM) and TNF-α?production (IC50?= 7 nM).1,2?It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4?Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4?QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5?QNZ has also been identified as a potent (IC50?= 25 nM complex 1 from?Y.lipolytica; IC50?= 14 nM complex 1 from?Bos Taurus?heart mitochondria) and selective inhibitor of mitochondrial complex I.6?QNZ?decreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7

Chemical Properties

White Solid

Uses

QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m

Uses

QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.

target

NF-κB

IC 50

NF-κB: 11 nM (IC50, in human Jurkat cells transfected with pNFκB-Luc)

References

[1] MASANORI TOBE. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation[J]. Bioorganic & Medicinal Chemistry, 2003, 11 3: Pages 383-391. DOI:10.1016/s0968-0896(02)00440-6
[2] MASANORI TOBE. A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives[J]. Bioorganic & Medicinal Chemistry, 2003, 11 18: Pages 3869-3878. DOI:10.1016/s0968-0896(03)00438-3
[3] SHINKYU CHOI. Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.[J]. The Journal of Biological Chemistry, 2006, 281 18: 12722-12728. DOI:10.1074/jbc.m601018200
[4] JUN WU. Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington’s disease treatment.[J]. Chemistry & biology, 2011, 18 6: 777-793. DOI:10.1016/j.chembiol.2011.04.012
[5] JUN WU. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington’s Disease Mouse Model[J]. The Journal of Neuroscience, 2016, 196 1: 125-141. DOI:10.1523/jneurosci.1038-15.2016
[6] ROBIN KRISHNATHAS. Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I.[J]. MedChemComm, 2017: 657-661. DOI:10.1039/c6md00655h
[7] DARIA CHERNYUK . Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease[J]. Neuroscience, 2019, 410: Pages 118-127. DOI:10.1016/j.neuroscience.2019.04.043

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Suppliers

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View Lastest Price from 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI 545380-34-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29

545380-34-5, 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINERelated Search:

HELENALIN 5-Aminosalicylic acid BAY 11-7085 IKK 16 MK-2206 2HCl 1,9-Pyrazoloanthrone Entinostat SB 203580 Olaparib Trimethoxypropylsilane BAY 11-7082 WITHAFERIN A ROCAGLAMIDE 3'-Hydroxyrocaglamide panepoxydone Rocaglamide I QNZ (EVP4593) N-(2-PHENYLETHYL)-4-QUINAZOLINAMINE

  • EVP4593; EVP 4593; EVP-4593
  • CS-902
  • NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem
  • QNZ
  • EVP 4593
  • EVP4593
  • EVP-4593
  • 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-
  • 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
  • N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine
  • QNZ (EVP4593)
  • QNZ (EVP4593);EVP-4593
  • N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine
  • NF-κB Activation Inhibitor
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLIN
  • CAY10470
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE USP/EP/BP
  • 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI
  • N4- [2- (4-phenoxyphenyl) ethyl] -4,6-neneneba quinazoline diamine
  • CAY10470|||EVP4593
  • QNZ, NF-kB inhibitor
  • QNZ/N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
  • QNZ, 10 mM in DMSO
  • QNZ (EVP4593) ，S4902
  • 545380-34-5
  • C22H20N4O
  • Inhibitors
  • Amines
  • Aromatics
  • Heterocycles
  • All Inhibitors
  • NF-kB