ChemicalBook > CAS DataBase List > Hydroxyprogesterone acetate
Hydroxyprogesterone acetate
- Product Name
- Hydroxyprogesterone acetate
- CAS No.
- 302-23-8
- Chemical Name
- Hydroxyprogesterone acetate
- Synonyms
- acetoxyprogesterone;17a-Acetoxyprogesterone;17α-hydroxyprogesterone 17-acetate;3,20-dioxopregn-4-en-17-yl acetate;17-ap;u5533;prodoxacetate;6,7-Dehydro-17α17α-Acetoxyprogesterone;Rivastigmine Impurity 51
- CBNumber
- CB7502523
- Molecular Formula
- C23H32O4
- Formula Weight
- 372.5
- MOL File
- 302-23-8.mol
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Hydroxyprogesterone acetate Property
- Melting point:
- 249-250°C
- Boiling point:
- 421.94°C (rough estimate)
- Density
- 1.0415 (rough estimate)
- refractive index
- 1.4433 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
- Water Solubility
- 1.01mg/L at 20℃
- λmax
- 241nm(EtOH)(lit.)
- BRN
- 2227870
- InChI
- InChI=1S/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23+/m1/s1
- InChIKey
- VTHUYJIXSMGYOQ-KOORYGTMSA-N
- SMILES
- C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)CC2
- CAS DataBase Reference
- 302-23-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 40-48
- Safety Statements
- 22-24/25-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- TU5074000
- HS Code
- 29372390
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- Y0001656
- Product name
- Chlormadinone acetate impurity G
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 25 mg
- Price
- $162
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- S517917
- Product name
- 17ALPHA-ACETOXYPROGESTERONE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- S517917
- Product name
- 17ALPHA-ACETOXYPROGESTERONE
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- A4125
- Product name
- 17α-Hydroxyprogesterone 17-acetate
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $192
- Updated
- 2023/06/20
TCI Chemical
- Product number
- H1527
- Product name
- 17α-Hydroxyprogesterone Acetate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $49
- Updated
- 2025/07/31
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Hydroxyprogesterone acetate Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Progesterone Acetate (Megestrol Acetate EP Impurity K) is an impurity in steroid drug Megestrol acetate (M208050).
Uses
An impurity in steroid drug Megestrol acetate (M208050).
Synthesis
83984-86-5
4134-58-1
The general procedure for the synthesis of the target compound (CAS: 4134-58-1) using the compound (CAS: 83984-86-5) as starting material was as follows: the diester (51 g, melting point 192-196°C) was dissolved in a solvent mixture of 1.4 liters of technical grade xylene and 510 ml of cyclohexanone. Water was removed from the system by distillation (250 ml of distillate was collected). Subsequently, aluminum isopropoxide (51 g) dissolved in 210 ml of xylene was added dropwise to the reaction system over a period of 5 minutes under slow distillation conditions, and distillation was continued for 45 minutes (another 210 ml of distillate was collected). Upon completion of the reaction, the mixture was rapidly cooled, the reaction was quenched by the addition of an ice-water mixture, and the remaining solvent was removed by steam distillation. The resulting solid product was collected by filtration and dried. The crude product was extracted using hot acetone and subsequently recrystallized by acetone to give 40.7 g (86% yield) of 17α-acetoxy-progesterone with a melting point of 240-243 °C. The melting point of the further purified sample was raised to 243-247 °C. *The 2% yield of the raw material is equivalent to 78.95%.
References
[1] Patent: EP1359154, 2003, A1. Location in patent: Page/Page column 16; 28; 30; 32
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 820,823
Hydroxyprogesterone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydroxyprogesterone acetate manufacturers
Wuhan JiyunZen Tech Co., Ltd.
- Product
- Hydroxyprogesterone acetate 302-23-8
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Hydroxyprogesterone acetate 302-23-8
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 97%-102%
- Supply Ability
- 100kg
- Release date
- 2021-08-05
Wuhan Biocar Pharmacy CO.,Ltd.
- Product
- Hydroxyprogesterone acetate 302-23-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 800kg
- Release date
- 2025-02-26
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