Tirofiban hydrochloride monohydrate

Tirofiban hydrochloride monohydrate Precautions Uses

Product Name: Tirofiban hydrochloride monohydrate
CAS No.: 150915-40-5
Chemical Name: Tirofiban hydrochloride monohydrate
Synonyms: Tirofiban HCl;Tirofiban hcl Monohydrate;MK-0383;682-504-6;Unii-6H925F8o5j;MK-383 Hydrochloride;Tirofiban HCl Hydrate;irofibanhydrochloride;TirofibanHcl142373-60-2/;Tirofiban Hydrochiloride
CBNumber: CB7506819
Molecular Formula: C22H39ClN2O6S
Formula Weight: 495.07
MOL File: 150915-40-5.mol

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Tirofiban hydrochloride monohydrate Property

Melting point:: 135-137°C
storage temp.: -20°C
solubility: DMSO: >12mg/mL at warmed to 60°C
form: powder
color: white to beige
optical activity: [α]/D -10 to -18° (c=1, MeOH)
Merck: 14,9464

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37-45
WGK Germany: 3
HS Code: 2935.90.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0246
Product name: Tirofiban hydrochloride monohydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0246
Product name: Tirofiban hydrochloride monohydrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $441
Updated: 2024/03/01

TCI Chemical

Product number: T3640
Product name: Tirofiban Hydrochloride Monohydrate
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $267
Updated: 2024/03/01

TCI Chemical

Product number: T3640
Product name: Tirofiban Hydrochloride Monohydrate
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $928
Updated: 2024/03/01

Alfa Aesar

Product number: H37492
Product name: Tirofiban hydrochloride monohydrate
Purity: 98%
Packaging: 1g
Price: $0
Updated: 2021/12/16

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Tirofiban hydrochloride monohydrate Chemical Properties,Usage,Production

Tirofiban hydrochloride monohydrate

Tirofiban is an anti-angina drug, it is successfully developed by the United States Merck company , Patent Number is EP 478363, and in 1998 it was sold in the United States, the trade name is Aggrastat,it is clinically used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherosclerotic plaque excision patients with in combination with heparin.
Drugs currently used in clinical are mainly tirofiban hydrochloride injections under the tradename Xin Weining, it is a reversible non-peptide platelet surface glycoprotein (GP) Ⅱb/Ⅲa receptor antagonist, it can competitively inhibit combination of fibrinogen and platelet (GP) Ⅱb/Ⅲa receptor . Intravenous injection is a dose-dependent inhibition of outside human platelet aggregation, prolonged bleeding time,and thrombosis caused by ADP, collagen, arachidonic acid,thromboxane analog U46619 and thrombin.
In healthy volunteers ,they are injected in routinely recommended doses, the peak plasma concentration is similar to that of steady-state plasma concentrations during the infusion ,T1/2 is 2h. Within 0.01~25 μg/ml dose range, PPB of this product is 65%, independent of concentration. Free drug accounts for 35% in plasma, Vd is 22~42 L. In healthy volunteers, CL is 213~314 ml/min, the renal clearance rate is 39%-69% of plasma clearance.
[Usage ]
(1) tirofiban hydrochloride monohydrate in combination with heparin is used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherectomy artery surgery patients.
(2) to give this product 0.4μg/(kg · min) bolus, 300 min, followed by a maintenance dose of 0.1μg/(kg · min). Unstable angina or non-Q-wave myocardial infarction patients need an infusion of 48~108 h. Row PTCA or atherectomy arterial patients need to continue infusion 12~24 h after surgery.
The above information is edited by the chemicalbook of Tian Ye.

Precautions

1. Adverse reactions: The most common adverse reactions are fever, or bleeding complications; other visible adverse reactions are nausea, headache, rash or urticaria, systemic reactions visible is reduction in platelet count.
2. Disable: allergy to the drug, the use of tirofiban in patients with thrombocytopenia occurring, there is active bleeding or bleeding constitution history before 30 days, history of intracranial hemorrhage, nearly a month of stroke or brain hemorrhage stroke, intracranial tumors, aneurysms, arteriovenous malformations, vital organs, surgery or severe trauma requiring surgical treatment, patients with aortic dissection, pericarditis, severe hypertension.
3. caution: recent (1 year) bleeding in patients, with coagulopathy, platelet disorder, or a history of thrombocytopenia, platelet count less than 150 × 109/L patients who have a history of cerebrovascular disease (1 year) , with recent subdural extracapsular surgery, nearly a month having a major surgery or a history of severe physical trauma, dissecting aneurysm, hemorrhagic retinal diseases, chronic hemodialysis patients.

Uses

Acute coronary syndrome (angina pectoris, myocardial infarction, surgery hydrant).
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. It can prevent platelet aggregation and thrombosis.

Chemical Properties

White Solid

Uses

A specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. An antithrombotic used in the treatment of unstable angina

Uses

Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina.

Uses

Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.

Definition

ChEBI: Tirofiban hydrochloride is a hydrochloride. It contains a tirofiban.

Biochem/physiol Actions

Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.

Tirofiban hydrochloride monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tirofiban hydrochloride monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tirofiban Hydrochloride 150915-40-5
Price: US $0.00/g
Min. Order: 10g
Purity: 99%min
Supply Ability: 1000g
Release date: 2021-09-10

Hebei Yanxi Chemical Co., Ltd.

Product: Tirofiban hydrochloride monohydrate 150915-40-5
Price: US $0.00-0.00/KG
Min. Order: 25KG
Purity: 0.99
Supply Ability: 50MT/month
Release date: 2024-04-25

Shanghai Joiny Pharmaceutical Co.,LTD

Product: N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride monohydrate 150915-40-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2024-03-12

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