METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
- Product Name
- METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
- CAS No.
- 287714-35-6
- Chemical Name
- METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
- Synonyms
- EOS-60344;Methyl 2-chloropyriMidine...;METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Methyl 2-chloropyrimidine-5- carboxylate, 95%;2-Chloropyrimidine-5-carboxylic acid methyl ester;2-chloro-pyrimidine-5-carboxylic acid methyl este;2-chloro-5-pyrimidinecarboxylic acid methyl ester;5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester;2-chloro-5-Pyrimidinecarboxylic acid methyl ester (9CI ACI);5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester (9CI, ACI)
- CBNumber
- CB7591301
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 287714-35-6.mol
METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Property
- Melting point:
- 76 °C
- Boiling point:
- 304.3℃
- Density
- 1.372
- Flash point:
- 138℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.14±0.22(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- RIDADR
- UN2811
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- M295735
- Product name
- Methyl2-Chloropyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 4H23-5-Y7
- Product name
- Methyl 2-chloropyrimidine-5-carboxylate
- Purity
- 98%
- Packaging
- 5G
- Price
- $750
- Updated
- 2021/12/16
- Product number
- 072625
- Product name
- Methyl 2-chloropyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $510
- Updated
- 2021/12/16
- Product number
- 4H23-5-Y7
- Product name
- Methyl 2-chloropyrimidine-5-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- W5141
- Product name
- Methyl2-chloropyrimidine-5-carboxylate
- Packaging
- 5g
- Price
- $284
- Updated
- 2021/12/16
METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Methyl 2-Chloropyrimidine-5-carboxylate could be useful the preparation of ACSS2 inhibitors, which are have anti-inflammatory and anti-depressant activity.
Synthesis
308348-93-8
287714-35-6
Step 3a. Synthesis of methyl 2-chloropyrimidine-5-carboxylate (Compound 1001-7): 2-Aminopyrimidine-5-carboxylic acid methyl ester (7 g, 0.046 mol) was added to a mixed solution of concentrated hydrochloric acid (15.2 mL) and dichloromethane (60 mL). After the reaction system was cooled, zinc chloride (18.6 g, 0.138 mol) was slowly added at 15-20 °C. The temperature was maintained at 15-20 °C and the reaction mixture was stirred for 0.5 h, followed by cooling to 5-10 °C. At this temperature, sodium nitrite (9.5 g, 0.138 mol) was added in batches to ensure that the internal temperature was maintained in the range of 5-10 °C. The reaction was continued for 2 hours. Upon completion, the reaction mixture was quenched by slowly pouring it into ice water (50 mL). The organic layer was separated and the aqueous phase was extracted twice with dichloromethane (30 mL x 2). The organic extracts were combined and concentrated to give the crude product (4.2 g). The crude product was suspended in hexane (20 mL), heated at 60°C for 30 min and filtered. Concentration of the filtrate gave the target compound methyl 2-chloropyrimidine-5-carboxylate (compound 1001-7, 3.5 g, 44.4% yield) as an off-white solid.LC-MS: m/z 214.1 [M+42]+.1H NMR (400 MHz, CDCl3): δ 4.00 (s, 3H), 9.15 (s, 2H).
References
[1] Patent: US2014/18368, 2014, A1. Location in patent: Paragraph 0162; 0179
[2] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 35
[3] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28; 29
METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Suppliers
- Tel
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- Country
- Belgium
- ProdList
- 6293
- Advantage
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View Lastest Price from METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE manufacturers
- Product
- methyl 2-chloropyrimidine-5-carboxylate 287714-35-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 287714-35-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2020-01-07