ChemicalBook > CAS DataBase List > METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE

METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE

Product Name: METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
CAS No.: 287714-35-6
Chemical Name: METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
Synonyms: EOS-60344;Methyl 2-chloropyriMidine...;METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Methyl 2-chloropyrimidine-5- carboxylate, 95%;2-Chloropyrimidine-5-carboxylic acid methyl ester;2-chloro-pyrimidine-5-carboxylic acid methyl este;2-chloro-5-pyrimidinecarboxylic acid methyl ester;5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester;2-chloro-5-Pyrimidinecarboxylic acid methyl ester (9CI ACI);5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester (9CI, ACI)
CBNumber: CB7591301
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 287714-35-6.mol

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METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Property

Melting point:: 76 °C
Boiling point:: 304.3℃
Density: 1.372
Flash point:: 138℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.14±0.22(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
RIDADR: UN2811
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M295735
Product name: Methyl2-Chloropyrimidine-5-carboxylate
Packaging: 1g
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 072625
Product name: Methyl 2-chloropyrimidine-5-carboxylate
Purity: 95+%
Packaging: 1g
Price: $99
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-Y7
Product name: Methyl 2-chloropyrimidine-5-carboxylate
Purity: 98%
Packaging: 1g
Price: $225
Updated: 2021/12/16

AK Scientific

Product number: W5141
Product name: Methyl2-chloropyrimidine-5-carboxylate
Packaging: 5g
Price: $284
Updated: 2021/12/16

Matrix Scientific

Product number: 072625
Product name: Methyl 2-chloropyrimidine-5-carboxylate
Purity: 95+%
Packaging: 5g
Price: $298
Updated: 2021/12/16

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METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Methyl 2-Chloropyrimidine-5-carboxylate could be useful the preparation of ACSS2 inhibitors, which are have anti-inflammatory and anti-depressant activity.

Synthesis

308348-93-8

287714-35-6

Step 3a. Synthesis of methyl 2-chloropyrimidine-5-carboxylate (Compound 1001-7): 2-Aminopyrimidine-5-carboxylic acid methyl ester (7 g, 0.046 mol) was added to a mixed solution of concentrated hydrochloric acid (15.2 mL) and dichloromethane (60 mL). After the reaction system was cooled, zinc chloride (18.6 g, 0.138 mol) was slowly added at 15-20 °C. The temperature was maintained at 15-20 °C and the reaction mixture was stirred for 0.5 h, followed by cooling to 5-10 °C. At this temperature, sodium nitrite (9.5 g, 0.138 mol) was added in batches to ensure that the internal temperature was maintained in the range of 5-10 °C. The reaction was continued for 2 hours. Upon completion, the reaction mixture was quenched by slowly pouring it into ice water (50 mL). The organic layer was separated and the aqueous phase was extracted twice with dichloromethane (30 mL x 2). The organic extracts were combined and concentrated to give the crude product (4.2 g). The crude product was suspended in hexane (20 mL), heated at 60°C for 30 min and filtered. Concentration of the filtrate gave the target compound methyl 2-chloropyrimidine-5-carboxylate (compound 1001-7, 3.5 g, 44.4% yield) as an off-white solid.LC-MS: m/z 214.1 [M+42]+.1H NMR (400 MHz, CDCl3): δ 4.00 (s, 3H), 9.15 (s, 2H).

References

[1] Patent: US2014/18368, 2014, A1. Location in patent: Paragraph 0162; 0179
[2] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 35
[3] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28; 29

METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Suppliers

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View Lastest Price from METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: methyl 2-chloropyrimidine-5-carboxylate 287714-35-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 287714-35-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2020-01-07

287714-35-6, METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATERelated Search:

METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE Ethyl 2-chloropyrimidine-5-carboxylate 2-Chloropyrimidine-5-carboxylic acid ethyl 2,4-dichloropyrimidine-5-carboxylate ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE METHYL 3-AMINO-5,6-DICHLORO-2-PYRAZINECARBOXYLATE ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Methyl2,4-Dichloropyrimidine-5-carboxylate Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE

2-chloro-5-pyrimidinecarboxylic acid methyl ester

2-Chloro-5-(methoxycarbonyl)pyrimidine, 2-Chloro-5-(methoxycarbonyl)-1,3-diazine

METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE

Methyl 2-chloropyriMidine...

2-Chloropyrimidine-5-carboxylic acid methyl ester

EOS-60344

2-chloro-pyrimidine-5-carboxylic acid methyl este

5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester

5-Pyrimidinecarboxylic acid, 2-chloro-, methyl ester (9CI, ACI)

2-chloro-5-Pyrimidinecarboxylic acid methyl ester (9CI ACI)

Methyl 2-chloropyrimidine-5- carboxylate, 95%

287714-35-6

Heterocycles

Heterocycle-Pyrimidine series