ML417

Product Name: ML417
CAS No.: 1386162-69-1
Chemical Name: ML417
Synonyms: ML417;ML417, 10 mM in DMSO;2-{4-[2-(4-methoxyphenoxy)ethyl]piperazine-1-carbonyl}-1H-indole;(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone;Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-;neuroprotection,dopaminergic,β-arrestin,ML417,ML-417,translocation,phosphorylation,neurons,ML 417,Inhibitor,Dopamine Receptor,inhibit
CBNumber: CB76183003
Molecular Formula: C22H25N3O3
Formula Weight: 379.45
MOL File: 1386162-69-1.mol

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ML417 Property

Boiling point:: 613.3±55.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 2mg/mL, clear
form: Solid
pka: 16.11±0.30(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0128977
Product name: ML417
Purity: 99.65%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0128977
Product name: ML417
Purity: 99.65%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0128977
Product name: ML417
Purity: 99.65%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

DC Chemicals

Product number: DC33653
Product name: ML417
Packaging: 250mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC33653
Product name: ML417
Packaging: 1g
Price: $1900
Updated: 2021/12/16

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ML417 Chemical Properties,Usage,Production

Uses

ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons[1].

Biological Activity

ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.

in vivo

In vivo pharmacokinetics experiments in mice (using 20 mg/kg; i.p.) reveals that ML417 is brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. ML417 displays a plasma T_max of 0.5 hours and C_max of 6500 ng/ml, and a brain T_max of 0.25 hours and C_max of 28000 ng/ml^[1].

Animal Model:	6-8 week old male C57BL/6 mice^[1]
Dosage:	20 mg/kg
Administration:	I.p. (Pharmacokinetic Analysis)
Result:	Brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. Displayed a plasma T_max of 0.5 hours and C_max of 6500 ng/ml, and a brain T_max of 0.25 hours and C_max of 28000 ng/ml.

IC 50

D₃ Receptor: 38 nM (EC₅₀)

References

[1] Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567. DOI:10.1021/acs.jmedchem.0c00424

ML417 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML417 Suppliers

China 40 United States 4 Global 44

Shanghai Lollane Biological Technology Co.,Ltd.

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ML417

Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-

neuroprotection,dopaminergic,β-arrestin,ML417,ML-417,translocation,phosphorylation,neurons,ML 417,Inhibitor,Dopamine Receptor,inhibit

(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone

2-{4-[2-(4-methoxyphenoxy)ethyl]piperazine-1-carbonyl}-1H-indole

ML417, 10 mM in DMSO

1386162-69-1