ChemicalBook > CAS DataBase List > tert-Butyl 3-aminopyrrolidine-1-carboxylate

tert-Butyl 3-aminopyrrolidine-1-carboxylate

Product Name
tert-Butyl 3-aminopyrrolidine-1-carboxylate
CAS No.
186550-13-0
Chemical Name
tert-Butyl 3-aminopyrrolidine-1-carboxylate
Synonyms
1-BOC-3-AMINOPYRROLIDINE;CAS:186550-13-0;Methyl N-benzyl-3-;1-Boc-3-aminopyrro;3-AMINO-1-BOC-PYRROLIDINE;3-AMINO-1-N-BOC-PYRROLIDINE;1-N-BOC-3-AMINO-PYRROLIDINE;1-Boc-3-aminopyrrolidine 95%;1-Boc-3-aminopyrrolidine ,97%;DL-3-AMINO-1-N-BOC-PYRROLIDINE
CBNumber
CB7664832
Molecular Formula
C9H18N2O2
Formula Weight
186.25
MOL File
186550-13-0.mol
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tert-Butyl 3-aminopyrrolidine-1-carboxylate Property

Boiling point:
257.4±33.0 °C(Predicted)
Density 
1.022
Flash point:
91°C
refractive index 
1.4710
storage temp. 
2-8°C
pka
9.55±0.20(Predicted)
form 
powder to lump to clear liquid
color 
White or Colorless to Light yellow
Sensitive 
Air Sensitive
CAS DataBase Reference
186550-13-0(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
36/37/38-44-41-22
Safety Statements 
26-36/37/39
RIDADR 
2810
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706582
Product name
1-Boc-3-aminopyrrolidine
Purity
95%
Packaging
1g
Price
$55.4
Updated
2025/07/31
TCI Chemical
Product number
B3890
Product name
3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$85
Updated
2025/07/31
TCI Chemical
Product number
B3890
Product name
3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$338
Updated
2025/07/31
TRC
Product number
T204658
Product name
Tert-butyl3-Aminopyrrolidine-1-carboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
Usbiological
Product number
263596
Product name
1-Boc-3-aminopyrrolidine
Packaging
1g
Price
$319
Updated
2021/12/16
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tert-Butyl 3-aminopyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Colorless low melting solid or liquid

Uses

1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

862906-31-8

186550-13-0

Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49) To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield. 1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H). Mass spectrum (m/z): 187 [M+H]+.

References

[1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37

tert-Butyl 3-aminopyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

3-Aminopyrrolidine dihydrochloride Ethanol Di-tert-butyl dicarbonate Sodium Triethylamine Tosyl chloride Tetrahydrofuran 1-(tert-Butoxycarbonyl)-3-pyrrolidinol Dichloromethane Methanol Sodium hydroxide Isopropyl alcohol 1-Butanol Ammonia

Preparation Products

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View Lastest Price from tert-Butyl 3-aminopyrrolidine-1-carboxylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-Boc-3-aminopyrrolidine 186550-13-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Career Henan Chemical Co
Product
tert-Butyl 3-aminopyrrolidine-1-carboxylate 186550-13-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-17

186550-13-0, tert-Butyl 3-aminopyrrolidine-1-carboxylateRelated Search:

Crospovidone Butyl acetate Povidone iodine Dibutyl phthalate Cyhalofop-butyl 3-Aminopyrrolidine Diethylene glycol monobutyl ether BUTYL OLEATE Buprofezin RESMETHRIN Polyvinylpyrrolidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone tert-butyl 3-bromoazetidine-1-carboxylate METHYL-2-PYRROLIDONE N-Boc-cis-4-Fmoc-Amino-L-proline N-Boc-trans-4-amino-L-proline methyl ester hydrochloride (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride

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  • CAS:186550-13-0
  • 186550-13-0
  • pharmacetical
  • Amines
  • Pyrrolidines
  • Pyrrole&Pyrrolidine&Pyrroline