2,4-Pyridinedicarboxylic acid
- Product Name
- 2,4-Pyridinedicarboxylic acid
- CAS No.
- 499-80-9
- Chemical Name
- 2,4-Pyridinedicarboxylic acid
- Synonyms
- 2,4-PDCA;2, 4-PDCA;lutidinicaci;LUTIDINIC ACID;4-Lutidinic Acid;2,4-LUTIDINIC ACID;RARECHEM AL BO 0286;Topirast impurity 10;2,4-Dicarboxypyridine;Tuobisite Impurity 20
- CBNumber
- CB7678217
- Molecular Formula
- C7H5NO4
- Formula Weight
- 167.12
- MOL File
- 499-80-9.mol
2,4-Pyridinedicarboxylic acid Property
- Melting point:
- 243-246 °C
- Boiling point:
- 295.67°C (rough estimate)
- Density
- 1.5216 (rough estimate)
- vapor pressure
- 0.001Pa at 25℃
- refractive index
- 1.6280 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- 2.49g/l
- form
- Crystalline Powder
- pka
- 2.15(at 25℃)
- color
- White to almost white
- Water Solubility
- Soluble in water at 20°C 4.5 g/L.
- λmax
- 258nm(MeOH aq.)(lit.)
- BRN
- 131631
- LogP
- 0.57
- CAS DataBase Reference
- 499-80-9(CAS DataBase Reference)
- EPA Substance Registry System
- 2,4-Pyridinedicarboxylic acid (499-80-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 8.21052
- Product name
- 2,4-Pyridinedicarboxylic acid
- Purity
- for synthesis
- Packaging
- 10g
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 04473
- Product name
- 2,4-Pyridinedicarboxylic acid
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $252
- Updated
- 2024/03/01
- Product number
- P0553
- Product name
- 2,4-Pyridinedicarboxylic Acid
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $132
- Updated
- 2023/06/20
- Product number
- P0553
- Product name
- 2,4-Pyridinedicarboxylic Acid Hydrate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- P2416
- Product name
- 2,4-Pyridinedicarboxylic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $69
- Updated
- 2024/03/01
2,4-Pyridinedicarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to almost white crystalline powder
Uses
2,4-Pyridinedicarboxylic Acid is a jumonji C (JmjC) histone demethylase inhibitor.
Uses
2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.
Definition
ChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4.
Flammability and Explosibility
Not classified
Biological Activity
2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of histone lysine-specific demethylases that targets on jmjd2a (kdm4a), kdm4c, kdm4e (ic50, 1.4 μm), kdm5b (ic50, 3 μm), kdm6a and other 2-oxogynases [1][2].histone lysine-specific demethylases jmjd2a (kdm4a) and kdm4c are both members of the jumonji domain 2 (jmjd2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. kdm5b is an h3k4me3⁄ me2-specific lysine demethylase [1][2].2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of jmjd2a (kdm4a), kdm4c and kdm5b. in the fdh-coupled assay, 2,4-pdca inhibited cckdm5b with ic50 value of 3 ± 1 μm. in maldi-tof analysis of h3(1-21)k4me3, 2,4-pdca reduced the level of h3(1-15) induced by cckdm5b. in u2-os cells transfected with kdm5b, 2,4-pdca inhibited the decrease of h3k4me3 [1]. in hg-treated vsmcs, 2,4-pdca (1.0 mm) inhibited jmjd2a and hg-induced proliferation in a concentration-dependent way, and inhibited hg-induced migration. 2,4-pdca also reduced the mrna and protein levels of mcp-1 and il-6 [2].in diabetic rats, 2,4-pdca (7.5 mg/kg/d) reduced neointimal area and i/m ratio in the injured arteries 28 days after injury. 2,4-pdca also inhibited the percentage of pcna-positive cells in the neointima [2].
References
[1]. kristensen lh, nielsen al, helgstrand c, et al. studies of h3k4me3 demethylation by kdm5b/jarid1b/plu1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. febs j, 2012, 279(11): 1905-1914.
[2]. qi h, jing z, xiaolin w, et al. histone demethylase jmjd2a inhibition attenuates neointimal hyperplasia in the carotid arteries of balloon-injured diabetic rats via transcriptional silencing: inflammatory gene expression in vascular smooth muscle cells. cell physiol biochem, 2015, 37(2): 719-734.
2,4-Pyridinedicarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Pyridinedicarboxylic acid manufacturers
- Product
- 2,4-Pyridinedicarboxylic acid 499-80-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- 2,4-Pyridinedicarboxylic acid 499-80-9
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%+
- Supply Ability
- 10000KG
- Release date
- 2019-12-27
- Product
- 2,4-Pyridinedicarboxylic acid 499-80-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03