3-FLUORO-4-HYDROXYPYRIDINE
- Product Name
- 3-FLUORO-4-HYDROXYPYRIDINE
- CAS No.
- 22282-73-1
- Chemical Name
- 3-FLUORO-4-HYDROXYPYRIDINE
- Synonyms
- 3-Fluoropyridin-4-ol;3-FLUORO-4-PYRIDINOL;4-Pyridinol, 3-fluoro-;3-fluoro-1H-pyridin-4-one;3-fluoropyridin-4(1H)-one;3-FLUORO-4-HYDROXYPYRIDINE;3-Fluoro-4-hydroxypyridine97%;3-FLUORO-4-HYDROXYPYRIDINE 97%;3-FLUORO-4-HYDROXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB7680719
- Molecular Formula
- C5H4FNO
- Formula Weight
- 113.09
- MOL File
- 22282-73-1.mol
3-FLUORO-4-HYDROXYPYRIDINE Property
- Melting point:
- 153 °C
- Boiling point:
- 315.8±22.0 °C(Predicted)
- Density
- 1.325±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.99±0.18(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F597433
- Product name
- 3-Fluoro-4-hydroxypyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F597433
- Product name
- 3-Fluoro-4-hydroxypyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0012546
- Product name
- 3-FLUORO-4-HYDROXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $994.46
- Updated
- 2021/12/16
- Product number
- PC201201
- Product name
- 3-Fluoropyridin-4-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- W4594
- Product name
- 3-Fluoro-4-hydroxypyridine
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
3-FLUORO-4-HYDROXYPYRIDINE Chemical Properties,Usage,Production
Synthesis
458532-97-3
22282-73-1
The general procedure for the synthesis of 3-fluoro-4-hydroxypyridine from 3-fluoropyridine-4-boronic acid was as follows: under standard reaction conditions, CuSO4-5H2O (0.049 g, 0.2 mmol) and 6.7 mol% acetamide (20 mg) were dissolved in methanol, followed by addition of 2 mmol of phenylboronic acid. The reaction mixture was placed in an oil bath preheated to 60 °C and kept under constant stirring at atmospheric pressure. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was washed twice with hot ethyl acetate to remove unreacted reactants and by-products. After removal of hot ethyl acetate by evaporation, the crude product was purified by column chromatography on silica gel (260 mesh) with an eluent ratio of petroleum ether:ethyl acetate (25:75). The recovered catalyst could be used directly in the next round of reaction. The final product was structurally confirmed by 1H NMR and 13C NMR spectra.
References
[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 395, p. 500 - 505
3-FLUORO-4-HYDROXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-HYDROXYPYRIDINE manufacturers
- Product
- 3-FLUORO-4-HYDROXYPYRIDINE 22282-73-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 3-FLUORO-4-HYDROXYPYRIDINE 22282-73-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-25