Diethyl L-glutamate hydrochloride
- Product Name
- Diethyl L-glutamate hydrochloride
- CAS No.
- 1118-89-4
- Chemical Name
- Diethyl L-glutamate hydrochloride
- Synonyms
- L-GLUTAMIC ACID DIETHYL ESTER HYDROCHLORIDE;Glu(OEt).OEt.HCl;L-Glutamic Acid Diethyl Ester HCl;Glu(oEt)2HCl;H-Glu(OEt)-Oet;H-Glu(OEt)-OEtCl;L-Glu(Oet)-Oet·HCl;H-GLU(OET)-OET HCL;H-L-Glu(OEt)-OEt·HCl;Diethyl L-glutamate HCl
- CBNumber
- CB7682344
- Molecular Formula
- C9H18ClNO4
- Formula Weight
- 239.7
- MOL File
- 1118-89-4.mol
Diethyl L-glutamate hydrochloride Property
- Melting point:
- 108-110 °C(lit.)
- refractive index
- 22.5 ° (C=3.6, EtOH)
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- color
- White to Almost white
- optical activity
- [α]18/D +22°, c = 1 in H2O
- BRN
- 3597595
- InChI
- InChI=1/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/s3
- InChIKey
- WSEQLMQNPBNMSL-WMASNCOMNA-N
- SMILES
- C(CC(=O)OCC)[C@H](N)C(=O)OCC.Cl |&1:7,r|
- CAS DataBase Reference
- 1118-89-4(CAS DataBase Reference)
- EPA Substance Registry System
- L-Glutamic acid, diethyl ester, hydrochloride (1118-89-4)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- MA1252280
- TSCA
- Yes
- HS Code
- 29224210
- Toxicity
- mouse,LD50,intraperitoneal,> 2gm/kg (2000mg/kg),Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 309346
- Product name
- L-Glutamic acid diethyl ester hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $21.84
- Updated
- 2025/07/31
- Product number
- 309346
- Product name
- L-Glutamic acid diethyl ester hydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $76.3
- Updated
- 2025/07/31
- Product number
- G0179
- Product name
- Diethyl L-Glutamate Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- G0179
- Product name
- Diethyl L-Glutamate Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- 453286
- Product name
- L-Glutamic Acid Diethyl Ester Hydrochloride
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
Diethyl L-glutamate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White crystal
Uses
L-Glutamic Acid Diethyl Ester Hydrochloride is a derivative of L-Glutamic Acid (G596960), a non-essential amino acid.
Uses
L-Glutamic acid diethyl ester hydrochloride can be used in the synthesis of:
- Oligo(γ-ethyl L-glutamate) via oligomerization catalyzed by papain.
- L-glutamic acid based dendritic compounds.
- Poly(α-peptide) by polymerization and copolymerization in the presence of protease catalysts.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
64-17-5
56-86-0
1118-89-4
To a 500 mL four-necked round-bottomed flask equipped with a mechanical stirrer, a thermometer and a reflux condenser tube (connected to a 30% aqueous sodium hydroxide solution absorption system), 300 g of ethanol, 14.7 g (0.10 mol) of L-glutamic acid, and 25.0 g (0.08 mol) of triphosgene were added sequentially. The reaction mixture was heated to 70-75°C and maintained at this temperature with stirring for 5 hours. Upon completion of the reaction, the system was cooled to 20-25°C and the hydrogen chloride gas generated in the system was removed by nitrogen displacement, a process that lasted for 30 minutes. Subsequently, the excess triphosgene and ethanol were recovered by distillation. To the residue, 100 mL of methyl tert-butyl ether was added for pulping, and after filtration and drying, 23.5 g of the white solid product L-glutamic acid diethyl ester hydrochloride was obtained. The product was analyzed by liquid chromatography with 99.7% purity and 98.0% yield.
References
[1] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[2] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0051; 0052
[3] Patent: CN108218739, 2018, A. Location in patent: Paragraph 0116; 0117
[4] Chemistry of Natural Compounds, 1994, vol. 30, # 2, p. 238 - 244
[5] Khimiya Prirodnykh Soedinenii, 1994, # 2, p. 261 - 268
Diethyl L-glutamate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Diethyl L-glutamate hydrochloride Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Country
- Americas
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View Lastest Price from Diethyl L-glutamate hydrochloride manufacturers
- Product
- L-glutamic acid diethyl ester hydrochloride 1118-89-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1 tons
- Release date
- 2025-05-12
- Product
- Diethyl L-glutamate hydrochloride 1118-89-4
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-10-19
- Product
- H-L-Glu(OEt)-OEt·HCl 1118-89-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-28