ChemicalBook > CAS DataBase List > Diethyl L-glutamate hydrochloride

Diethyl L-glutamate hydrochloride

Product Name
Diethyl L-glutamate hydrochloride
CAS No.
1118-89-4
Chemical Name
Diethyl L-glutamate hydrochloride
Synonyms
L-GLUTAMIC ACID DIETHYL ESTER HYDROCHLORIDE;Glu(OEt).OEt.HCl;L-Glutamic Acid Diethyl Ester HCl;Glu(oEt)2HCl;H-Glu(OEt)-Oet;H-Glu(OEt)-OEtCl;L-Glu(Oet)-Oet·HCl;H-GLU(OET)-OET HCL;H-L-Glu(OEt)-OEt·HCl;Diethyl L-glutamate HCl
CBNumber
CB7682344
Molecular Formula
C9H18ClNO4
Formula Weight
239.7
MOL File
1118-89-4.mol
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Diethyl L-glutamate hydrochloride Property

Melting point:
108-110 °C(lit.)
refractive index 
22.5 ° (C=3.6, EtOH)
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Soluble in water
form 
powder to crystal
color 
White to Almost white
optical activity
[α]18/D +22°, c = 1 in H2O
BRN 
3597595
InChI
InChI=1/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/s3
InChIKey
WSEQLMQNPBNMSL-WMASNCOMNA-N
SMILES
C(CC(=O)OCC)[C@H](N)C(=O)OCC.Cl |&1:7,r|
CAS DataBase Reference
1118-89-4(CAS DataBase Reference)
EPA Substance Registry System
L-Glutamic acid, diethyl ester, hydrochloride (1118-89-4)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
MA1252280
TSCA 
Yes
HS Code 
29224210
Toxicity
mouse,LD50,intraperitoneal,> 2gm/kg (2000mg/kg),Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
309346
Product name
L-Glutamic acid diethyl ester hydrochloride
Purity
97%
Packaging
5g
Price
$21.84
Updated
2025/07/31
Sigma-Aldrich
Product number
309346
Product name
L-Glutamic acid diethyl ester hydrochloride
Purity
97%
Packaging
25g
Price
$76.3
Updated
2025/07/31
TCI Chemical
Product number
G0179
Product name
Diethyl L-Glutamate Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
G0179
Product name
Diethyl L-Glutamate Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$55
Updated
2025/07/31
Usbiological
Product number
453286
Product name
L-Glutamic Acid Diethyl Ester Hydrochloride
Packaging
1g
Price
$305
Updated
2021/12/16
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Diethyl L-glutamate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

L-Glutamic Acid Diethyl Ester Hydrochloride is a derivative of L-Glutamic Acid (G596960), a non-essential amino acid.

Uses

L-Glutamic acid diethyl ester hydrochloride can be used in the synthesis of:

  • Oligo(γ-ethyl L-glutamate) via oligomerization catalyzed by papain.
  • L-glutamic acid based dendritic compounds.
  • Poly(α-peptide) by polymerization and copolymerization in the presence of protease catalysts.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

64-17-5

56-86-0

1118-89-4

To a 500 mL four-necked round-bottomed flask equipped with a mechanical stirrer, a thermometer and a reflux condenser tube (connected to a 30% aqueous sodium hydroxide solution absorption system), 300 g of ethanol, 14.7 g (0.10 mol) of L-glutamic acid, and 25.0 g (0.08 mol) of triphosgene were added sequentially. The reaction mixture was heated to 70-75°C and maintained at this temperature with stirring for 5 hours. Upon completion of the reaction, the system was cooled to 20-25°C and the hydrogen chloride gas generated in the system was removed by nitrogen displacement, a process that lasted for 30 minutes. Subsequently, the excess triphosgene and ethanol were recovered by distillation. To the residue, 100 mL of methyl tert-butyl ether was added for pulping, and after filtration and drying, 23.5 g of the white solid product L-glutamic acid diethyl ester hydrochloride was obtained. The product was analyzed by liquid chromatography with 99.7% purity and 98.0% yield.

References

[1] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[2] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0051; 0052
[3] Patent: CN108218739, 2018, A. Location in patent: Paragraph 0116; 0117
[4] Chemistry of Natural Compounds, 1994, vol. 30, # 2, p. 238 - 244
[5] Khimiya Prirodnykh Soedinenii, 1994, # 2, p. 261 - 268

Diethyl L-glutamate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diethyl L-glutamate hydrochloride manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
L-glutamic acid diethyl ester hydrochloride 1118-89-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1 tons
Release date
2025-05-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Diethyl L-glutamate hydrochloride 1118-89-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-10-19
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Glu(OEt)-OEt·HCl 1118-89-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-28

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  • AMINE
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  • Peptide Synthesis
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  • Protected & Labeled Amino Acids
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  • Amino Acid Ethyl Esters
  • peptides
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  • Biochemistry
  • Amino hydrochloride
  • Glutamic AcidNeurotransmitters
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