Dimethyl methoxymethylenemalonate
- Product Name
- Dimethyl methoxymethylenemalonate
- CAS No.
- 22398-14-7
- Chemical Name
- Dimethyl methoxymethylenemalonate
- Synonyms
- DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
- CBNumber
- CB7686827
- Molecular Formula
- C7H10O5
- Formula Weight
- 174.15
- MOL File
- 22398-14-7.mol
Dimethyl methoxymethylenemalonate Property
- Melting point:
- 40-44 °C
- Boiling point:
- 98 °C (0.5 mmHg)
- Density
- 1.2311 (rough estimate)
- refractive index
- 1.4390 (estimate)
- Flash point:
- 158 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- Crystalline Solid
- color
- White
- InChI
- InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3
- InChIKey
- RHFZTBSULNJWEI-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)/C(=C\OC)/C(OC)=O
- CAS DataBase Reference
- 22398-14-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 43-36/38-22
- Safety Statements
- 37/39-26-24
- HS Code
- 29171990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P284Wear respiratory protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M1207
- Product name
- Dimethyl Methoxymethylenemalonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $32
- Updated
- 2022/04/27
- Product number
- M1207
- Product name
- Dimethyl Methoxymethylenemalonate
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $361
- Updated
- 2021/12/16
- Product number
- B23803
- Product name
- Dimethyl methoxymethylenemalonate, 98+%
- Packaging
- 10g
- Price
- $32.4
- Updated
- 2021/12/16
- Product number
- B23803
- Product name
- Dimethyl methoxymethylenemalonate, 98+%
- Packaging
- 50g
- Price
- $86.1
- Updated
- 2021/12/16
- Product number
- B23803
- Product name
- Dimethyl methoxymethylenemalonate
- Purity
- 98+%
- Packaging
- 250g
- Price
- $291
- Updated
- 2021/12/16
Dimethyl methoxymethylenemalonate Chemical Properties,Usage,Production
Chemical Properties
white crystalline solid
Uses
Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.
Synthesis
264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.
Dimethyl methoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dimethyl methoxymethylenemalonate manufacturers
- Product
- DIMETHYL METHOXYMETHYLENEMALONATE 22398-14-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10