3-Hydroxypiperidine

Background

Product Name: 3-Hydroxypiperidine
CAS No.: 6859-99-0
Chemical Name: 3-Hydroxypiperidine
Synonyms: PIPERIDIN-3-OL;3-PIPERIDINOL;Benidipine Impurity 17;3-hydroxyperidine;3-HYDROXYPIPERIDINE;3-Hydroxypiperadine;OEM 3-Hydroxypiperidin;3-Hydroxypiperidine>3-HYDROXYPIPERIDINE 98%;(3R)-3-piperidin-1-iumol
CBNumber: CB7687884
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 6859-99-0.mol

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3-Hydroxypiperidine Property

Melting point:: 57-61 °C
Boiling point:: 67-69 °C (2 mmHg)
Density: 1.016±0.06 g/cm3(Predicted)
Flash point:: >100°C
storage temp.: 2-8°C
solubility: ethanol: 0.1 g/mL, clear
pka: 14.91±0.20(Predicted)
form: Crystalline Powder and Lumps
color: White to light yellow
PH: 11.5-11.7 (H2O)Aqueous solution
Water Solubility: soluble
Sensitive: Air Sensitive & Hygroscopic
BRN: 102696
InChIKey: BIWOSRSKDCZIFM-UHFFFAOYSA-N
LogP: -0.35
CAS DataBase Reference: 6859-99-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-20/21/22-36/37/38
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 56210
Product name: 3-Hydroxypiperidine
Purity: 99%
Packaging: 10g
Price: $38.58
Updated: 2024/03/01

Sigma-Aldrich

Product number: 56210
Product name: 3-Hydroxypiperidine
Purity: ≥98.0% (NT)
Packaging: 50g
Price: $115.8
Updated: 2024/03/01

TCI Chemical

Product number: H0412
Product name: 3-Hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: H0412
Product name: 3-Hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $88
Updated: 2024/03/01

Alfa Aesar

Product number: L01333
Product name: 3-Hydroxypiperidine, 98+%
Packaging: 2g
Price: $18.65
Updated: 2024/03/01

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3-Hydroxypiperidine Chemical Properties,Usage,Production

Background

Many piperidine derivatives have multiple pharmacological activities such as antibacterial, antitumor, treatment of Alzheimer's disease and anesthesia. They are also important drugs for the treatment of viral infections (including AIDS) and diabetes. 3-Hydroxypiperidine or its derivatives are one of the important intermediates, which are widely used in the synthesis of drug intermediates such as chiral 3-aminopiperidine. It is of great significance to develop a synthesis method suitable for industrial production.

Chemical Properties

White to light yellow crystalline powder and lumps

Application

3-Hydroxypiperidine may be used to synthesize the following:
2-pyrrolidinone via oxidation with iodosylbenzene
1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines

Uses

3-Hydroxypiperidine is usually used for Synthesis of unsymmetrical ureas,Synthesis of piperidine nucleoside analogs,Fluorination reactions,Synthesis of substituted pyridines.

General Description

3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine.

Synthesis

Dissolve 86.0g of 5-bromo-2-hydroxypentylamine hydrobromide in 150mL of water, and add a solution of 60mL of water containing 15.0g of sodium carbonate at 10-15°C, and drip it for about 1 hour. After dripping, react at about 15°C for 2 hours. Then heat to 30-40°C and react for 2 hours. Stop the reaction, cool it to room temperature, and concentrate the reaction solution under reduced pressure to remove most of the water. Filter it to remove salt, wash it with cold water, and continue to concentrate the mother liquor. The crude product is distilled under reduced pressure to obtain 26.5g of colourless oily 3-hydroxypiperidine, yielding 80%.

3-Hydroxypiperidine Preparation Products And Raw materials

Raw materials

3-Hydroxypiperidine hydrochloride Ethyl acetate Sodium hydroxide

Preparation Products

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3-Hydroxypiperidine Suppliers

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View Lastest Price from 3-Hydroxypiperidine manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: 3-Hydroxypiperidine 6859-99-0
Price: US $100.00-2000.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 5MT per Month
Release date: 2021-01-11

Shanghai Yongzeng Technology Co.,Ltd

Product: 3-Hydroxypiperidine 6859-99-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-03

Hebei Kingfiner Technology Development Co.Ltd

Product: 3-Hydroxypiperidine 6859-99-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000kg
Release date: 2024-06-19

6859-99-0, 3-HydroxypiperidineRelated Search:

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PIPERIDIN-3-OL

3-Hydroxypiperadine

3-PIPERIDINOL

3-HYDROXYPIPERIDINE

3-HYDROXYPIPERIDINE 98%

3-Hydroxypiperidine/3-Piperidinol

Benidipine Impurity 17

3-PIPERIDINOL FOR SYNTHESIS 10 G

3-Hydroxypiperidine, 98% 10GR

3-Hydroxypiperidine, 98% 50GR

3-Hydroxypiperidine, 97+%

3-Piperidinol 3-Hydroxypiperidine

3-Hydroxypiperidine >=98.0% (NT)

3-Piperidinol for synthesis

(3R)-3-piperidin-1-iumol

OEM 3-Hydroxypiperidin

3-Hydroxypiperidine&gt

3-Hydroxypiperidine USP/EP/BP

3-hydroxyperidine

6859-99-0

8859-99-0

C5H11NO

C5H11N1O1

AMINE

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6859-99-0