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4-BOCAMINO-NICOTINIC ACID

Product Name
4-BOCAMINO-NICOTINIC ACID
CAS No.
171178-34-0
Chemical Name
4-BOCAMINO-NICOTINIC ACID
Synonyms
4-BOCAMINO-NICOTINIC ACID;4-TERT-BUTOXYCARBONYLAMINO-NICOTINIC ACID;4-Tert-butoxycarbonylamino-nicatinec acid;4-{[(tert-butoxy)carbonyl]aMino}pyridine-3-carboxylic acid;4-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-;4-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-pyridinecarboxylic acid
CBNumber
CB7692761
Molecular Formula
C11H14N2O4
Formula Weight
238.24
MOL File
171178-34-0.mol
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4-BOCAMINO-NICOTINIC ACID Property

Boiling point:
348.4±27.0 °C(Predicted)
Density 
1.293±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
1.70±0.36(Predicted)
Appearance
White to light yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AK Scientific
Product number
W3733
Product name
4-Boc-Aminonicotinicacid
Packaging
100mg
Price
$81
Updated
2021/12/16
Matrix Scientific
Product number
072740
Product name
4-Boc-Aminonicotinic acid
Purity
95+%
Packaging
1g
Price
$159
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0007033
Product name
4-BOC-AMINONICOTINIC ACID
Purity
95.00%
Packaging
250MG
Price
$214.2
Updated
2021/12/16
Matrix Scientific
Product number
072740
Product name
4-Boc-Aminonicotinic acid
Purity
95+%
Packaging
5g
Price
$1038
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0007033
Product name
4-BOC-AMINONICOTINIC ACID
Purity
95.00%
Packaging
1G
Price
$1085.7
Updated
2021/12/16
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4-BOCAMINO-NICOTINIC ACID Chemical Properties,Usage,Production

Synthesis

280115-84-6

171178-34-0

General procedure for the synthesis of 4-((tert-butoxycarbonyl)amino)nicotinic acid from methyl 4-((tert-butoxycarbonyl)amino)nicotinate: 4-((tert-butoxycarbonyl)amino)nicotinic acid methyl ester (6.02 g, 23.86 mmol) was dissolved in dioxane (100 mL), and an aqueous sodium hydroxide solution (0.970 N, 28.05 mL, 27.20 mmol ). The reaction mixture was heated to 60°C and held for 1 hr and subsequently cooled to room temperature. To the cooled mixture was added aqueous hydrochloric acid (1.03 M, 26.99 mL, 27.20 mmol) and then extracted with chloroform (5 x 100 mL). The organic phases were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 4-((tert-butoxycarbonyl)amino)nicotinic acid as a creamy solid (4.70 g, 83% yield).

References

[1] Patent: WO2006/100310, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: WO2005/32481, 2005, A2. Location in patent: Page/Page column 42-43
[3] Patent: WO2005/32481, 2005, A2. Location in patent: Page/Page column 42-43

4-BOCAMINO-NICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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171178-34-0, 4-BOCAMINO-NICOTINIC ACIDRelated Search:


  • 4-BOCAMINO-NICOTINIC ACID
  • 4-TERT-BUTOXYCARBONYLAMINO-NICOTINIC ACID
  • 4-{[(tert-butoxy)carbonyl]aMino}pyridine-3-carboxylic acid
  • 4-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-pyridinecarboxylic acid
  • 3-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-
  • 4-Tert-butoxycarbonylamino-nicatinec acid
  • 4-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylic acid
  • 171178-34-0