3,4-(Methylenedioxy)aniline

ChemicalBook > CAS DataBase List > 3,4-(Methylenedioxy)aniline

3,4-(Methylenedioxy)aniline

Product Name: 3,4-(Methylenedioxy)aniline
CAS No.: 14268-66-7
Chemical Name: 3,4-(Methylenedioxy)aniline
Synonyms: benzo[d][1,3]dioxol-5-amine;1,3-BENZODIOXOL-5-AMINE;enedioxy)aniL;AKOS BBS-00004239;5-Aminobenzodioxole;Methylenedioxyaniline;Paroxetine Impurity 62;5-Amino-1,3-benzodioxo;4-aMino-1,3-benzodioxole;3,4-Methylendioxyaniline
CBNumber: CB7695555
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 14268-66-7.mol

Less

3,4-(Methylenedioxy)aniline Property

Melting point:: 39-41 °C(lit.)
Boiling point:: 144 °C16 mm Hg(lit.)
Density: 1.2528 (rough estimate)
refractive index: 1.5030 (estimate)
Flash point:: 289 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.78±0.20(Predicted)
form: Low Melting Solid
color: Dark brown to black
Water Solubility: slightly soluble
Sensitive: Air & Light Sensitive
BRN: 4919
CAS DataBase Reference: 14268-66-7(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Benzodioxol-5-amine(14268-66-7)
EPA Substance Registry System: 1,3-Benzodioxol-5-amine (14268-66-7)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
HS Code: 29329970

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 161497
Product name: 3,4-(Methylenedioxy)aniline
Purity: 97%
Packaging: 10g
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: 161497
Product name: 3,4-(Methylenedioxy)aniline
Purity: 97%
Packaging: 50g
Price: $137
Updated: 2024/03/01

TCI Chemical

Product number: M0741
Product name: 3,4-Methylenedioxyaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $73
Updated: 2024/03/01

TCI Chemical

Product number: M0741
Product name: 3,4-Methylenedioxyaniline
Purity: >98.0%(GC)(T)
Packaging: 100g
Price: $218
Updated: 2024/03/01

Alfa Aesar

Product number: A12975
Product name: 3,4-(Methylenedioxy)aniline, 98+%
Packaging: 10g
Price: $30.65
Updated: 2024/03/01

Less

3,4-(Methylenedioxy)aniline Chemical Properties,Usage,Production

Chemical Properties

dark brown to black low melting solid

Uses

3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.

Synthesis

A 10mL-sealed tube was charged with 5-bromobenzo[d][1,3]dioxole (1mmol), CuI (19mg, 0.1mmol), and DMEDA (13mg/16μL, 0.15mmol) in NH4OH (1.5mL, 27% NH3 in H2O) and DMSO (0.5mL). The tube was flushed with Ar gas before being capped. The solution was stirred at 130°C or 110°C for the given times. The resulting suspension was cooled to room temperature, and saturated aqueous Na2SO4 solution (5mL) was added. The resulting solution was extracted with EtOAc (20mL×3). The organic layer was separated, dried over MgSO4, filtered, and concentrated. The residue was purified by flash column chromatography to give 3,4-(Methylenedioxy)aniline.

Purification Methods

Crystallise the base from pet ether and/or distil it in a vacuum. The hydrochloride has m 198o(dec). [Sonn & Benirschke Chem Ber 54 1734 1921, Beilstein 19 H 328, 19 II 341, 19 III/IV 4056.]

3,4-(Methylenedioxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

3,4-(METHYLENEDIOXY)PHENYL ISOCYANATE

Less

3,4-(Methylenedioxy)aniline Suppliers

Americas 1 Belgium 4 Canada 1 China 186 Egypt 1 Europe 3 Germany 12 India 14 Japan 3 Slovakia 1 South Korea 1 Switzerland 4 United Kingdom 17 United States 42 Global 290

Shijiazhuang Benchu Technology Co., Ltd.

Tel: 0311-68015059 17367983103
Email: 925646462@qq.com
Country: China
ProdList: 20
Advantage: 58

Shaoxing Fangxiao Chemical Co., LTD

Tel: +86-13456999252; 13456999252
Email: shellyhouse39@126.com
Country: China
ProdList: 44
Advantage: 58

TIANJIN JINGYE FINE CHEMICAL CO.,LTD.

Tel: 18202564928
Email: 214896283@QQ.COM
Country: China
ProdList: 600
Advantage: 58

Xi'an Synthetize Industrial Co., Ltd.

Tel: 15934815775
Email: lintengfei@xa-sks.com
Country: China
ProdList: 34
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

RYSS TECH LTD

Tel: 400-188-0725 +86 21 34310725 13611771617
Fax: +86 21 34311076
Country: China
ProdList: 2002
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9459
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1972
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3991
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9346
Advantage: 58

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

Yangzhou Crownyoung Chemical Technology Co.,Ltd.

Tel: +86-514-87325376 +86-514-87180828
Fax: +86-514-87325396 +86-514-87180928
Email: cy@crownyoung.com
Country: China
ProdList: 84
Advantage: 56

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.

Tel: 021-69106960 13701823733
Fax: 021-69106780
Email: 13701823733@163.com
Country: China
ProdList: 4767
Advantage: 60

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11481
Advantage: 59

Beijing Holiyang Chemical Co. Ltd.

Tel: 13718199399
Fax: QQ : 206661479
Email: holiyangchem@163.com
Country: China
ProdList: 3381
Advantage: 56

Shanghai YouPeng Chemical Co. Ltd.

Tel: 021-69005955 13701776567
Fax: 021-69005775
Email: youpengchem@163.com
Country: China
ProdList: 4293
Advantage: 56

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536
Fax: QQ : 121102042
Email: hanovichem@163.com
Country: China
ProdList: 3383
Advantage: 56

Shanghai TongYuan Chemical Co., Ltd.

Tel: 021-021-69182866 13701855675
Fax: 021-69182022
Email: tongyuanchem@126.com
Country: China
ProdList: 4321
Advantage: 58

Shanghai Kaisai Chemical Co., Ltd

Tel: 021-33516722 13701817765
Fax: 021-33516776
Email: kaisaichem@163.com
Country: China
ProdList: 4741
Advantage: 58

Shanghai LanRun Chemical Co., Ltd.

Tel: 021-69515658 ; 69515628 13701998368
Fax: 021-69515998
Email: longrunchem@163.com
Country: China
ProdList: 3912
Advantage: 50

Shanghai Rolead Chemical Technology Co., Ltd.

Tel: 021-69992220 13701886816
Fax: 021-69992237
Email: roleadchem@163.com
Country: China
ProdList: 4750
Advantage: 50

Shanghai Kangtuo Chemical Co., Ltd.

Tel: 021-69185552 13701777608
Fax: 021-69186006
Email: kangtuochem@163.com
Country: China
ProdList: 4360
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 3970
Advantage: 60

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Less

View Lastest Price from 3,4-(Methylenedioxy)aniline manufacturers

Career Henan Chemical Co

Product: 3,4-(Methylenedioxy)aniline 14268-66-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: as request
Release date: 2018-12-23

14268-66-7, 3,4-(Methylenedioxy)anilineRelated Search:

4-(Trifluoromethoxy)aniline O-Tolidine 2-Aminophenol Aniline Bis(2-ethylhexyl)amine p-Anisidine Triethanolamine ALTRENOGEST (Trifluoromethoxy)benzene Black Pepper Oil o-Toluidine N-Ethylmethylamine p-Anisaldehyde 1,3-Benzodioxole Glycine Triethylamine p-Toluidine ANILINE BLACK

benzo[d][1,3]dioxol-5-amine

5-Amino-1,3-benzodioxole 98%

1,3-Benzodioxol-5-amine, 3,4-(Methylenedioxy)aniline

5-Amino-1,3-benzodioxole 4-Amino-1,2-methylenedioxybenzene

3,4-METHYLENEDIOXYANILINE (STABILISED WI

3,4-(Methylenedioxy)aniline, 97% 10GR

3,4-(Methylenedioxy)aniline, 97% 50GR

4-aMino-1,3-benzodioxole

3,4-(Methylenedioxy)aniline, 98+%, 98+%

3,4-Methylendioxyaniline

3,4-Methylenedioxyaniline 1,3-Benzodioxol-5-amine

(BENZO[1,3]DIOXOL-5-YL)AMINE

1,3-BENZODIOXOL-5-AMINE

1-Amino-3,4-dimethylenedioxybenzene

1-Amino-3,4-methylenedioxybenzene

AKOS BBS-00004239

5-AMINO-1,3-BENZODIOXOLE

4-AMINO-1,2-METHYLENEDIOXYBENZENE

3,4-(METHYLENEDIOXY)ANILINE

5-Aminobenzodioxole

Aniline, 3,4-(methylenedioxy)-

Methylenedioxyaniline

3,4-(Methylenedioxy)aniline, 98+%

(BENZO[1,3]DIOXOL-5-YL)AMIN

3,4-Methylenedioxyaniline 98%

3,4-methylendioxy-analin

3,4-(Methylenedioxy)aniline,97%

3,4－（methylenediocy）aniline

Paroxetine Impurity 62

3,4-Methylenedioxyaniline&gt

enedioxy)aniL

5-Amino-1,3-benzodioxo

14268-66-7

4268-66-7

AMINE

Organic Building Blocks

Nitrogen Compounds

Building Blocks

Amines

Anilines, Aromatic Amines and Nitro Compounds