ChemicalBook > CAS DataBase List > L-Alanine methyl ester hydrochloride

L-Alanine methyl ester hydrochloride

Product Name
L-Alanine methyl ester hydrochloride
CAS No.
2491-20-5
Chemical Name
L-Alanine methyl ester hydrochloride
Synonyms
ALANINE METHYL ESTER HYDROCHLORIDE;ALA-OME.HCL;ALANINE-OME HCL;METHYL L-ALANINATE HYDROCHLORIDE;L-Ala-OMe.HCL;(S)-Methyl 2-aMinopropanoate hydrochloride;L-alanina;anine methyL;H-ALA-OME HCL;A-Ala-OMe·HCl
CBNumber
CB7715055
Molecular Formula
C4H10ClNO2
Formula Weight
139.58
MOL File
2491-20-5.mol
More
Less

L-Alanine methyl ester hydrochloride Property

Melting point:
109-111 °C(lit.)
alpha 
7 º (c=2, CH3OH 24 ºC)
refractive index 
6.5 ° (C=2, MeOH)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Powder
color 
White to off-white
optical activity
[α]25/D +7.0°, c = 1.6 in methanol
Water Solubility 
Soluble in Water (100 mg/ml).
Sensitive 
Hygroscopic
BRN 
3594033
InChI
InChI=1/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/s3
InChIKey
IYUKFAFDFHZKPI-OQFXAWDINA-N
SMILES
C(=O)(OC)[C@@H](N)C.Cl |&1:4,r|
CAS DataBase Reference
2491-20-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
29224999
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
330639
Product name
L-Alanine methyl ester hydrochloride
Purity
99%
Packaging
5g
Price
$39.7
Updated
2025/07/31
Sigma-Aldrich
Product number
330639
Product name
L-Alanine methyl ester hydrochloride
Purity
99%
Packaging
25g
Price
$115
Updated
2025/07/31
Sigma-Aldrich
Product number
S378909
Product name
ALANINE METHYL ESTER HYDROCHLORIDE
Purity
AldrichCPR
Packaging
250MG
Price
$159
Updated
2022/05/15
TCI Chemical
Product number
A1466
Product name
L-Alanine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
A1466
Product name
L-Alanine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$85
Updated
2025/07/31
More
Less

L-Alanine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

L-Alanine methyl ester hydrochloride is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-41-7

2491-20-5

The general procedure for the synthesis of (S)-alanine methyl ester hydrochloride (1a) from methanol and L-alanine was as follows: 15 mL of anhydrous methanol was first added to a round-bottomed flask according to the literature (Xing et al., 2012). At -15 °C, 2.16 mL of SOCl2 (0.03 mol) was slowly added dropwise to methanol and the reaction was maintained at 0 °C for 1 hour. Another round bottom flask was taken and 14 mL of anhydrous methanol and 1.4 mL (0.019 mol) of SOCl2 was added followed by 1.118 g of L-alanine and heated to reflux for 1.5 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure, and the pre-prepared SOCl2 solution was poured into the reaction flask and refluxing was continued for 1.5 h to give product 1a (100% yield). Since the hydrochloric acid generated by the reaction was not favorable for the subsequent steps, NaHCO3 was added to the reaction flask at the end of reflux to neutralize the acidity until no bubbles were generated. Finally, the solution was concentrated to obtain 1b (100% yield). Fusaric acid (4) was dissolved with 1b in 15 mL of dichloromethane in a round-bottomed flask with homogeneous stirring, followed by the addition of excess catalysts dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), and refluxed for 24 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by preparative HPLC (25-45% CH3CN/H2O, 20 min) to afford the product 1c (52% yield).

References

[1] Phytochemistry Letters, 2018, vol. 26, p. 50 - 54
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 36, p. 11683 - 11687
[3] Angew. Chem., 2018, vol. 130, # 36, p. 11857 - 11861,5
[4] Journal of Organic Chemistry, 2008, vol. 73, # 7, p. 2898 - 2901
[5] Tetrahedron Asymmetry, 2009, vol. 20, # 9, p. 1036 - 1039

L-Alanine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-Alanine methyl ester hydrochloride Suppliers

Americas 1 Austria 1 Belgium 1 China 474 Europe 4 France 2 Germany 7 Hungary 2 India 42 Japan 7 Poland 1 Slovakia 1 South Korea 1 Switzerland 5 United Kingdom 16 United States 58 Global 623
Hubei Xinkang Pharmaceutical Chemical Co., Ltd
Tel
027-027-59308705 18871579363
Fax
027-59308705
Email
1248680011@qq.com
Country
China
ProdList
9850
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
13316949107 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9564
Advantage
58
Hubei Hengluyuan Technology co.ltd
Tel
027-88188016 18717196322
Email
1764683941@qq.com
Country
China
ProdList
6456
Advantage
58
Yangzhou Xuda Biotechnology Co., Ltd
Tel
15161820588; 15161820588
Email
xdchemical2024@163.com
Country
China
ProdList
91
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Sichuan Tongsheng Amino acids Co.,Ltd.
Tel
0838-2274206 13908101207
Fax
+86-838-2274207
Email
sales@biots.cn
Country
China
ProdList
279
Advantage
66
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
ProdList
1733
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
AllyChem Co., Ltd.
Tel
0411-62313318 13942603642
Fax
0411-87549748
Email
info@allychem.com
Country
China
ProdList
1028
Advantage
65
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2647
Advantage
55
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
More
Less

View Lastest Price from L-Alanine methyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Ala-Ome.Hcl 2491-20-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-22
Henan Aochuang Chemical Co.,Ltd.
Product
L-Alanine methyl ester hydrochloride 2491-20-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-27
Wuhan Boyuan Import & Export Co., LTD
Product
L-Alanine methyl ester hydrochloride 2491-20-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000ton
Release date
2023-08-15

2491-20-5, L-Alanine methyl ester hydrochlorideRelated Search:

Kresoxim-methyl Paraquat dichloride Methylphenidate hydrochloride L-Alanine D-Alanine EC 2.6.1.2 Phenprobamate Methylparaben Topotecan hydrochloride Acetonitrile Methyl acrylate Basic Violet 1 Methanol Methyl rac-Tenofovir-d7 Chloromethyl isopropyl carbonate ChloroMethyl Propyl Carbonate (S)-Tenofovir

  • l-alanicemethylesterhydrochloride
  • ALANINE-OME HCL
  • ALANINE METHYL ESTER HYDROCHLORIDE
  • L-2-AMINOPROPIONIC ACID METHYL ESTER HYDROCHLORIDE
  • L-ALANINE METHYL ESTER HYDROCHLORIDE SALT
  • L-ALANINE METHYL ESTER HCL
  • H-Ala-OMe·HCl L-Alanine Methyl ester hydrochloride
  • L-Alanine Methyl ester hydrochloride, 99% 5GR
  • (S)-2-Aminopropionic Acid Methyl Ester Hydrochloride H-Ala-OMe.HCl
  • Methyl (2S)-2-aMinopropanoate hydrochloride
  • (S)-Methyl 2-aMinopropanoate hydrochloride
  • L-Alanine Methyl ester hydrochloride 99%
  • L-ALANINE METHYL ESTER HYDROCHLORIDE
  • METHYL L-ALANINATE HYDROCHLORIDE
  • H-L-ALA-OME HCL
  • H-ALA-OME HCL
  • H-ALA-OME HYDROCHLORIDE
  • (S)-2-AMINOPROPIONIC ACID METHYL ESTER HYDROCHLORIDE
  • L-Alanine methyl ester hydrochloride≥ 99% (HPLC)
  • L-Alanine Methyl ester HCl (S)-2-Aminopropionic Acid Methyl Ester Hydrochloride
  • L-Alanine Methyl Ester Hydrochloride,99%e.e.
  • L-aminopropionic acid methyl ester hydrochloride
  • A-Ala-OMe·HCl
  • L-Alanina Methyl Ester HCl
  • L-alanina
  • L-Ala-Ome·HCl L-Alanine methyl ester hydrochloride
  • L-ALANINE METHYL ESTER HCI
  • (2S)-2-Aminopropanoic acid methyl·hydrochloride
  • Alanine methyl·hydrochloric acid
  • Ala-OMe·Hydrochloride
  • L-Alanine methyl·hydrochloric acid
  • L-Ala-OMe·Hydrochloride
  • L-Ala-OMe.HCL
  • Nα-Benzoyl-L-arginine ethyl ester hydrochloride ,98%
  • L-Alanine methyl est
  • L-ALANINE METHYL ESTER HYDROCHLORIDE, 99 %
  • Alanine methyl ester, HCl
  • ALA-OME.HCL
  • (1-methoxy-1-oxopropan-2-yl)ammonium
  • anine methyL
  • Tenofovir Impurity 47 HCl
  • Tenofovir disoproxil Impurity 27
  • L-Alanine Methyl Ester Hydrochloride &gt
  • (S)-Methyl 2-aminopropanoate hydrochloride,99%
  • L-Alanine, methyl ester, hydrochloride (1:1)
  • L-ALANINE METHYL ESTER HYDROCHLORIDE 2491-20-5
  • L-Alanine methyl ester hydrochloride USP/EP/BP
  • (S)-Methyl 2-aminopropanoate hydrochloride,0.99
  • L-Alanyl Methyl Ester Hydrochloride extrapure, 99%
  • Tenofovir Impurity 4 HCl
  • H - Ala - OMe . HCI
  • L Analine Methyl Ester
  • L-Alanine methyl ester hydrochloride, 98%
  • Tenofovir Impurity 12 HCl
  • <sc>L</sc>-Alanine methyl ester hydrochloride
  • 2491-20-5
  • 2191-20-5
  • 491-20-5